Neuronal signals

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  • This book is about how to construct and use computational models of specific parts of the nervous system, such as a neuron, a part of a neuron or a network of neurons. It is designed to be read by people from a wide range of backgrounds from the biological, physical and computational sciences. The word ‘model’ can mean different things in different disciplines, and even researchers in the same field may disagree on the nuances of its meaning.

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  • Extracellular signal-regulated kinase (ERK) is a versatile protein kinase that regulates many cellular functions. Growing evidence suggests that ERK1⁄2 plays a crucial role in promoting cell death in a variety of neuro-nal systems, including neurodegenerative diseases.

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  • During the last decades, numerous studies about stem cells and regenerative medicine highlighted new therapeutic approaches to treat several neurological disorders. It is noteworthy that the current optimism over potential stem cell therapies is driven by new understandings of stem cell biology leading to specific cell fate decision.

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  • Harrison's Internal Medicine Chapter 29. Disorders of the Eye The Human Visual System The visual system provides a supremely efficient means for the rapid assimilation of information from the environment to aid in the guidance of behavior. The act of seeing begins with the capture of images focused by the cornea and lens upon a light-sensitive membrane in the back of the eye, called the retina. The retina is actually part of the brain, banished to the periphery to serve as a transducer for the conversion of patterns of light energy into neuronal signals.

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  • If one asks what neuroscience is, the answer can be found in this book. Neuroscience embraces not only anatomical and physiological studies but also cell biology, computer science, and biochemistry. Equally important for neuroscientific research are other disciplines, such as psychology, psychiatry, neurology and additional recent ones, such as neuroeconomics and social neuroscience. This book comprises chapters on diverse topics in neuroscience ranging from cellular, computational, cognitive, and clinical neuroscience.

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  • Advances in the diagnosis, prevention, treatment and cure of neurological diseases are based upon scientific discovery. The journey from discovery to treatment is often arduous and involves both basic and clinical science. Over the ages, multiple intertwined paths of discovery connect the recognition of distinct diseases of the nervous system to exquisite diagnostic descriptions, which, when coupled with the scientific understanding of the disease, have allowed the development of effective treatments and interventions...

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  • Use the best speaker cables you can. Higher quality cables, available from your specialty dealer, are recommended and will give you superior performance. Spade connectors are suggested for optimum contact and ease of installation. Attach your speaker cables to the Signal Input section on the rear panel. Be consistent when connecting speaker leads to the terminals on the back of the Cinema: take great care to assign the same color to the (+) terminal on both the speaker and the amplifier. Please see the Operations section (pages 5) of this manual for more details....

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Possible Cis-acting signal that could be involved in the localization of different mRNAs in neuronal axons

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Nicotine signals through muscle-type and neuronal nicotinic acetylcholine receptors in both human bronchial epithelial cells and airway fibroblasts...

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  • EURASIP Journal on Applied Signal Processing 2003:7, 620–628 c 2003 Hindawi Publishing Corporation Analog VLSI Circuits for Short-Term Dynamic Synapses Shih-Chii Liu Institute of Neuroinformatics, University of Zurich and ETH Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland Email: Received 14 May 2002 and in revised form 25 September 2002 Short-term dynamical synapses increase the computational power of neuronal networks.

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  • EURASIP Journal on Applied Signal Processing 2003:7, 649–658 c 2003 Hindawi Publishing Corporation Analog VLSI Models of Range-Tuned Neurons in the Bat Echolocation System Matthew Cheely Neurosciences and Cognitive Sciences Program, University of Maryland, College Park, MD 20742, USA Email: Timothy Horiuchi Department of Electrical and Computer Engineering, University of Maryland, College Park, MD 20742, USA Institute for Systems Research, University of Maryland, College Park, MD 20742, USA Email: timmer@isr.umd.

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain

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  • Human disc-large homolog (hDlg), also known as synapse-associated protein 97, is a scaffold protein, a member of the membrane-associated guanylate kinase family, implicated in neuronal synapses and epithelial– epithelial cell junctions whose expression and function remains poorly char-acterized in most tissues, particularly in the vasculature.

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  • The hypothesis thatL-glutamate (Glu) is an excitatory amino acid neurotransmitter in the mammalian central nervous system is now gaining more support after the suc-cessful cloning of a number of genes coding for the signaling machinery required for this neurocrine at synapses in the brain. These include Glu receptors (signal detection), Glu transporters (signal termination) and vesicular Glu trans-porters (signal output through exocytotic release).

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  • The newestmember of themitogenactivatedprotein (MAP) kinase family of proteins, extracellular signal regulated kinase 5 (ERK5; also known as big-mitogen activated kinase 1 or BMK1) is widely expressed in many tissues including the brain. Although growth factor activation of ERK5 innon-neuronal cells has been shown to contribute to cell proliferation, differentiation and transformation, until recently no information was available on the role of ERK5 in neuronalsurvival.

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  • The extracellular signal regulated protein kinases (ERK1/2) are essential for normal development and functional plasti-city of the central nervous system. However, a growing number of recent studies in models of cerebral ischemia, brain trauma and neurodegenerative diseases implicate a detrimental role for ERK1/2 signaling during oxidative neuronal injury. Neurons undergoing oxidative stress-rela-ted injuries typically display a biphasic or sustained pattern of ERK1/2 activation.

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  • Extracellular signal regulated kinases 1 and 2 (ERK1/2) regulate cellular responses to a varietyof extracellular stimuli. In the nervous system, ERK1/2 is critical for neur-onal differentiation, plasticityand mayalso modulate neuronal survival. In this minireview, we present evidence that supports prosurvival activityof ERK1/2 in neurons. Several reports suggest that ERK1/2 mediates neuropro-tective activityof extracellular factors, including neurotro-phins. In addition, ERK1/2 is activated byneuronal injury....

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Systems analysis of circadian time-dependent neuronal epidermal growth factor receptor signaling...

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  • Calcium is an extraordinarily versatile signaling ion, encoding cellular responses to a wide variety of external stimuli. In neurons, mitochondria can accumulate enormous amounts of calcium, with the consequence that mitochondrial calcium uptake, sequestration and release play pivotal roles in orchestrating calcium-dependent responses as diverse as gene transcrip-tion and cell death.

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  • Signal transducers and activators of transcription (STATs) regulate a vari-ety of cellular functions, including differentiation and proliferation. STAT3 and STAT5 are known to play important roles in brain processes, such as energy homeostasis and neuronal development. We isolated a novel splicing variant ofSTAT5Afrom a cDNA library of the mouse brainstem.

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