Functional Magnetic Resonance Imaging of brain is typically called fMRI. It has
become a fundamental modality of imaging at any MRI suite of service center or
hospital. Our book has been compiled with the aim of incorporating a wide range of
applied neuropsychological evaluation methods. It is aimed at those who are
embarking on neuropsychological research projects, as well as relatively experienced
psychologists and neuroscientists who might wish to further develop their
Data were included from individuals participating in a
prospective study of 2,126 Medicare recipients, 65 years
and older, residing in a single community in Northern Man-
hattan. Each person received the same medical, neurological
and neuropsychological evaluations at regular intervals. The
cohort was followed over a 7-year period beginning in 1992.
Three follow-up examinations took place at 20-month in-
tervals after the baseline interview. Over the study period,
the annual mortality rate has been 8.
When the first edition of this book was published in 1993, I commented how
notions regarding Tourette’s syndrome (TS) had undergone recent dramatic
changes. Major shifts in views of the disorder included identification of its
complex spectrum of clinical features (including tics and specific behavioral
disorders, particularly obsessive-compulsive disorder and attention deficit
hyperactivity disorder), establishment of heredity as a major etiological
factor, and recognition that, rather than a rare disorder, it occurs quite
commonly in the population....
In the century since the neuronal inclusions [neurofibrillary tangles
(NFTs); Fig. 1] and extracellular protein aggregates (Aft plaques; Fig. 1)
that form the pathological hallmarks of Alzheimer's disease (AD) were described,
our knowledge of all aspects of AD has grown markedly. AD is
uniformly progressive and ultimately results in debilitating cognitive impairment.
In the early stages, the impairment may only be apparent on neuropsychological testing; however, by end stage, few functions above the
automatic remain unaffected (Forstl and Kurz, 1999)....