Xem 1-20 trên 23 kết quả Neurotoxin
  • The botulinum neurotoxins (BoNTs) are the most potent protein toxins for humans. There are seven serotypes of BoNTs (A–G), based on a lack of cross-antiserum neutralization. The BoNT⁄C and BoNT⁄D serotypes include mosaic toxins that are organized as D–C and C–D toxins.

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  • The seven serotypes ofClostridium botulinumneurotoxins (A–G) are the deadliest poison known to humans. They share significant sequence homo-logy and hence possess similar structure–function relationships. Botulinum neurotoxins (BoNT) act via a four-step mechanism, viz.,

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  • The four-domain structure of botulinum neurotoxins (BoNTs) reflects their multistep intoxication process. The high toxicity of BoNTs primarily results from specific binding and uptake into neurons mediated by their 50-kDa cell-binding fragment (HC). X-ray crystallography data have revealed that the HCfragment consists of two domains of equal size, named the 25-kDa N-terminal half of HC(HCN) and the 25-kDa C-terminal half of HC(HCC).

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  • Tiếp theo việc khảo sát các thành phần của nọc rắn hổ đất trong bài báo này chúng tôi xin trình bày việc tách các neurotoxin từ nọc rắn hổ đất Việt Nam (N. kaouthia) với mục đích tìm kiếm các toxin mới để ứng dụng vào điều trị các bệnh về thần kinh.

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  • There is a commonly held myth in our society that anything that is “natural” is good, wholesome, and healthful, whereas anything that is “synthetic” is bad, toxic, and harmful. The mere mention of the word chemical is enough to strike terror into the heart of any food faddist. This attitude is, at best, naïve and, at worst, dangerous.

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  • Weak neurotoxins from snake venom are small proteins with five disulfide bonds, which have been shown to be poor bindersof nicotinicacetylcholine receptors.We report on the cloning and sequencing of four cDNAs encoding weak neurotoxins fromNaja sputatrixvenomglands. The protein encoded by one of them, Wntx-5, has been synthesized by solid-phase synthesis and characterized.

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: "Binding of long-chain α-neurotoxin would stabilize the resting state of nAChR: A comparative study with α-conotoxin

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Repeated administration of the noradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) modulates neuroinflammation and amyloid plaque load in mice bearing amyloid precursor protein and presenilin-1 mutant transgenes

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  • A major unmet clinical need exists for long-acting neurotherapeutics to alleviate chronic pain in patients unresponsive to available nonaddictive analgesics. Herein, a new strategy is described for the development of potent and specific inhibitors of the neuronal exocytosis of transmitters and pain mediators that exhibit unique antinociceptive activity.

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  • The NMR solution structures of NTX-1 (PDB code 1W6B and BMRB 6288), a long neurotoxin isolated from the venom ofNaja naja oxiana, and the molecular dynamics simulation of these structures are reported. Calculations are based on 1114NOEs, 19 hydrogen bonds, 19 dihedral angle restraints and secondary chemical shifts derived from 1 Hto 13 C HSQC spectrum. Similar to other long neurotoxins, the three-finger like structure shows a double and a triple strandedb-sheet aswell as some flexible regions, particularly at the tip of loop II and the C-terminal tail....

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  • Botulinum neurotoxin type A (BoNT⁄A), the most toxic substance known to mankind, is produced by Clostridium botulinumtype A as a complex with a group of neurotoxin-associated proteins (NAPs) through polycis-tronic expression of a clustered group of genes. NAPs are known to protect BoNT against adverse environmental conditions and proteolytic digestion. Hemagglutinin-33 (Hn-33) is a 33 kDa subcomponent of NAPs that is resistant to protease digestion, a feature likely to be involved in the protec-tion of the botulinum neurotoxin from proteolysis. ...

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  • Bài báo này trình bày việc tách, làm sạch và khảo sát độc tính của một số phân đoạn từ nọc rắn hổ mang Việt Nam.

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  • Chất độc tác động lên nguyên sinh chất tế bào (protoplasmic poisons): Nhóm chất độc thuộc loại này phá hủy các tế bào, từ đó nó làm hư hại một số cơ quan, tổ chức trong cơ thể. Nhóm độc tố tác động lên hệ thống thần kinh (neurotoxins): Nhóm chất độc này gây ra các triệu chứng thần kinh như: Sự ra mồ hôi quá độ, hôn mê, chứng co giật, ảo giác, chứng kích động, suy nhược, liệt cơ kết tràng...

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  • Harrison's Internal Medicine Chapter 134. Botulism Definition Botulism is a paralytic disease caused by potent protein neurotoxins elaborated by Clostridium botulinum. Illness begins with cranial nerve involvement and proceeds caudally to involve the extremities. Cases may be classified as (1) food-borne botulism, from ingestion of preformed toxin in food contaminated with C.

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  • Some examples of metabolic inhibitors are the inhibitors of multi-function oxidases, carbohydrate and amino-acid metabolism inhibitors, and chitin-synthesis inhibitors (Krieger, 2001). The neurotoxins act through acetylcholinesterase, the neurotoxin that affects ion permeability, intervening in the nerve receptors of insects (Haynes, 1988), killing the arthropod by disrupting the membrane integrity (Gill et al, 1992). The main groups of insecticides can be studied using the following classification: neurotoxins, insect growth regulators, cellular respiration inhibitors, and others....

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  • Botulism is a paralytic disease caused by potent protein neurotoxins elaborated by Clostridium botulinum. Illness begins with cranial nerve involvement and proceeds caudally to involve the extremities. Cases may be classified as (1) food-borne botulism, from ingestion of preformed toxin in food contaminated with C. botulinum; (2) wound botulism, from toxin produced in wounds contaminated with the organism; and (3) intestinal botulism, from ingestion of spores and production of toxin in the intestine of infants (infant botulism) or adults.

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  • The neurotransmitter dopamine has been shown to inhibit fibrillation of a-synuclein by promoting the formation of nonamyloidogenic oligomers. Fibrillation ofa-synuclein is accelerated in the presence of pesticides and the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

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  • Rapid evolution driven by positive Darwinian selection appears in toxins of vipers, scorpions, and marine snails. Although the vast phylogenetic distan-ces between these animals suggest that this phenomenon is common, the recent release of the genome ofNematostella vectensis(Starlet anemone) as a collection of contigs portrays another extreme.

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  • Poneratoxin is a small neuropeptide found in the venom of the antParaponera clavata. It is stored in the venom reservoir as an inactive 25-residue peptide. Here we des-cribe both chemically synthesized poneratoxin and pon-eratoxin obtained by expression in insect cells. When expressed in insect cells, poneratoxin was observed attached to cell membranes. Both synthetic and recom-binant ponerotoxins were soluble below pH 4.5. The structure of synthetic poneratoxin was characterized by circular dichroism and solved by nuclear magnetic reso-nance. ...

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  • Chemical Exposure Continued exposure of some children to lead in their environment—a well-known neurotoxin—is having serious effects on their development. And experts have increasing concerns about children being exposed to chemicals in the environment and resultant neurodevelopmental disorders such as attention deficit hyperactivity disorder (ADHD). The North American Commission for Environmental Cooperation’s (CEC) children’s environmental health indicators initiative was making important progress in coming to grips with the scale of this problem.

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