New biomarkers

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Soluble RAGE: a hot new biomarker for the hot joint?

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer?

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  • The current global epidemic of pulmonary tuberculosis has highlighted the need for new screening tests that are rapid and accurate. The social burden of pulmonary tuberculosis has increased because many patients are also infected with human immunodeficiency virus (HIV), and the rates of multidrug-resistant tuberculosis are increasing.1 However, screening technology has not changed greatly during the past several decades. Many highburden countries depend upon sputum smears and chest radiographs, supplemented by cultures when resources permit.

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  • There is a need for development of new diagnostic tools to allow earlier detection of active disease, predict disease progression and evaluate the response to periodontal therapy, thereby improving the clinical management of patients with periodontal diseases. Advances in periodontal diseases diagnostic research are moving toward methods whereby periodontal risk can be identified and quantified by objective measures such as biomarkers.

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  • A major challenge in clinical periodontics is to find a reliable molecular marker of periodontal support loss with high sensitivity, specificity and utility (Buduneli & Kinane 2011). Molecules derived from inflamed host tissue and pathogenic bacteria have the potential of being used as markers of periodontitis; however, molecular markers of bone resorption have advantages as they relate to specificity for bone, easy detection, pre-analytic stability and availability of sensitive and specific assays for detection (Forde et al. 2006).

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  • Recently, the use of oral fluids such as GCF, whole saliva and oral rinse as a means of evaluating host-derived products, as well as exogenous components (for instance: oral microorganisms and microbial products), has been suggested as potential sources and diagnostic markers, respectively for disease susceptibility (Sahingur and Cohen 2004; Buduneli and Kinane 2011).

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  • In response to various pressures, businesses have begun to report externally on their environmental policy and performance. The significance of such external reporting depends on the extent of changes in management culture and systems and on how new measures influence management decisions. The 'greening of accountancy' involves a reappraisal of how to identify and measure the relevant costs of processes and products (such as 'Total Cost Assessment') and a redesign of incentive mechanisms.

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  • The impact of biomarkers in present day health care system, health management and healthy life is enormous. Clinicians need them for diagnosis, prognosis, effect of therapeutic intervention, and most importantly, for early detection of a disease. Pharmaceutical industries need them for new drug discovery and drug efficiency test. Regulatory authorities need them for testing toxicity and environmental impact. Epidemiologists need them for population screening and risk factor determination.

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  • In recent years, completion of the sequencing of the human genome as well as the genomes of dozens of other organisms and subsequent development of tools for comprehensive analysis of other cellular constituents have revolutionized biology. These new technologies, referred to broadly as “genomics,” have integrated biologic sciences with information sciences and engineering.

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  • Since the 1990s, Pollution Probe has focused its programmes on issues related to air pollution, water pollution and human health, including a major programme to remove human sources of mercury from the environment. Pollution Probe’s scope has recently expanded to new concerns, including the unique risks that environmental contaminants pose to children, the health risks related to exposures within indoor environments, and the development of innovative tools for promoting responsible environmental behaviour.

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  • In the 16th century, Leonardo da Vinci had described “The narrowing of the passage of blood vessels, thickening of the coats of these vessels and hardening of arteries”. This is the first documentation of atherosclerosis, but today our understanding of atherogenesis as a process of a chronic inflammatory disease has been updated by many mechanisms such as hypercholesterolemia, dysfunction of endothelial cells, oxidation of lipoproteins and espe‐ cially oxidative stress. In particular, the endothelium is responsible for the...

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  • Today, cancer research is focused on determining how genome and proteome level information may be useful as tools in prevention, diagnosis, and prognosis. The development of “omics” technologies, such as proteomics and transcriptomics has opened new research areas for scientists working on cancer research.

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  • Serum prostate specific antigen (PSA) is the only biomarker routinely used for the early detection of prostate cancer, but it is not a perfect test. Although PSA is highly specific for prostate, an elevated level is not specific for cancer, being increased in benign hyperplasia and prostatitis (Pungalia, 2006; Bozeman, 2002). Consequently, the majority of men with an increased serum PSA do not have prostate cancer and thus undergo unnecessary prostate biopsies.

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  • In his opening address to the conference, Jon wood, who coordinates the research programme at the Institute, traced the origins of the conference to a series of exploratory conversations on the relationship between archaeology and contemporary art with independent curator Katy rochester. From the outset, wood, rochester and their colleagues in leeds sought proposals from archaeologists who were interested in sculpture and in sharing new ideas with sculpture historians.

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  • Nutrigenomics, proteomics and metabolomics are three new disciplines that will contribute to the rapid development of functional foods. Bioinformatics is a new tool that uses computer database technology to integrate data from multiple, and sometimes disparate, disciplines. Already these disciplines and tools have improved our understanding of food science and human nutrition. Discoveries in genetics make it possible to understand the effects of nutrients in processes at the molecular level in the body and also the variable effects of dietary components on each individual.

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Serum levels of biomarkers of bone and cartilage destruction and new bone formation in different cohorts of patients with axial spondyloarthritis with and without tumor necrosis factor-alpha blocker treatment...

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  • Many cancer patients are diagnosed at a stage in which the cancer is too far advanced to be cured, and most cancer treatments are effective in only a minority of patients undergoing therapy. Thus, there is tremendous opportunity to improve the outcome for people with cancer by enhancing detection and treatment approaches. Biomarkers will be instrumental in making that transition.

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  • The past ten years are witness to many changes in line with this objective. Trading and settlement procedures have been improved. New instruments have been introduced. Disclosure levels have been enhanced. Measures to protect investors’ interest and educate them have been initiated at least on paper. A code of corporate governance has been put in place. Steps were initiated to change the organisational structure of the stock exchanges.

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  • Thus, a search for new biomarkers which could be more specific for the detection of prostate cancer is needed. The use of biomarkers such as percent free PSA (Lee, 2006), intact serum PSA (Steuber, 2002), serum pro-PSA(Lein, 2005) and kallikrein (Stephan, 2000) have shown to be useful in the detection of prostate cancer. However, although a biomarker could improve the precision of screening it is possible that in clinical practice it is not viable, for the need of fresh samples or high costs (Villanueva, 2006). The use of PSA velocity has been suggested, an increase of more than 0.

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  • The registry of the new city was then contacted until the individual was located. Changes of residence were recorded in a database with the exact date of moving. In the case of death, date and city of death were provided by the local registry office. Cause of death was either ascertained through a record linkage system of the NRW regional statistical office or through the local health offices. The record linkage system has been described in detail by Klug and colleagues (2003). Local health offices provided an anonymous copy of the relevant death certificate.

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