Xem 1-20 trên 251 kết quả New drugs
  • Introduction: 3,4-Methylenedioxyamphetamines (MDAs), which were described as a new drug class “entactogens” a by Nichols [1], are being abused to enhance mutual understanding, communicativeness and empathy together with their hallucinogenic effects [1–3]. They are known as a group of designer drugs, and include 3,4-methylenedioxyamphetamine(MDA), 3,4-methylenedioxymethamphetamine(MDMA), 3,4-methylenedioxyethylamphetamine (MDEA) and N-methyl-1-(3,4-methylenedioxyphenyl)-2-butanamine(MBDB) ( Fig. 7.1). Of the MDAs, MDA, MDMA and MDEA are strictly controlled by laws b.

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  • In a certain sense, the field of drug metabolism (DM) is standing still. More specifically, the basic experiment of drug metabolism (i.e., administering a new drug to an animal or human and determining the structures, amounts, and disposition of the metabolites) has changed very little over a period of decades. Remarkably, the experimental design and resulting data set from a typical absorption, distribution, metabolism, and excretion (ADME) study conducted today would be instantly recognized and understood by DM scientists from 50 years ago.

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về y học đề tài: Recently published papers: New evidence for old debates, new drugs and some timely reminders...

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Equipoise, design bias and randomized controlled trials: the elusive ethics of new drugs – a comment...

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Respirable antisense oligonucleotides: a new drug class for respiratory disease...

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  • Discovery of a new chemical entity that exerts pharmacological effects for curing or treating diseases or relieving symptoms is only the first step in the drug developmental process. In the developmental cycle of a new drug, the delivery of a desired amount of a therapeutic agent to the target at a specific time or duration is as important as its discovery. In order to realize the optimal therapeutic outcomes, a delivery system should be designed to achieve the optimal drug concentration at a predetermined rate and at the desired location....

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Equipoise, design bias, and randomized controlled trials: the elusive ethics of new drug development...

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  • The discovery of efficacious new human therapeutic agents is one of humanity’s most vital tasks. It is an enormously demanding activity that requires creativity, a vast range of scientific knowledge, and great persistence. It is also an exceedingly expensive activity. In an ideal world, no education would be complete without some exposure to the ways in which new medicines are discovered and developed. For those young people interested in science or medicine, such knowledge is arguably mandatory....

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  • Introduction: The advancement of technologies was marvelous during the past half century; new analytical instruments have been being invented and improved. About 30 years ago, thin-layer chromatography (TLC) was being used most widely for detection and identification of drugs and poisons. Around that time, the use of GC/MS started in the field of medicine. Therefore, an ideal procedure for analysis of drugs and poisons was considered to be the screening by TLC, followed by the final identification and quantitation by GC/MS.

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  • Introduction: Toluene, benzene, xylene and styrene are being widely used for chemical product materials, solvents and constituents of adhesives and paints, and thus sometimes cause poisoning incidents by inhaling their gas at chemical product-manufacturing factories. The abuse of thinner solvents, containing toluene, benzene and xylene, is now a social problem especially for young people. There are many crimes and poisoning incidents involving the thinner solvent abuse.

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  • Preclinical drug development. Discovery of new drugs in the laboratory is an exercise in prediction • Techniques of discovery. Sophisticated molecular modelling allows precise design of potential new therapeutic substances and new technologies have increased the rate of development of potential medicines. Studies in animals and in humans Prediction. Failures of prediction occur and a drug may be abandoned at any stage, including after marketing. New drug development is a colossally expensive and commercially driven activity. ...

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  • We must be daring and search after Truth; even if we do not succeed in finding her, we shall at least come closer than we are at present (Galen AD 130-200) SYNOPSIS (CONTINUED) Surveillance studies and the reporting of spontaneous adverse reactions respectively determine the clinical profile of the drug and detect rare adverse events. Further trials to compare new medicines with existing medicines are also required.These form the basis of cost-effectiveness comparisons.

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  • Introduction: Organophosphorus pesticides (organophosphate pesticides) are being most widely used as insecticides, and thus cause poisoning cases frequently. The organophosphorus pesticides at the early stage, such as parathion and TEPP, had powerful insecticidal effects and high toxicity for both humans and beasts, and caused poisoning accidents during spraying. Although many less toxic organophosphorus pesticides were then developed, the resistance to the pesticides was acquired by insects during their repeated use, resulting in less effectiveness of the pesticides.

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  • Despite massive efforts in drug discovery fueled by combinatory chemistry, recombinant DNA technology, and highthroughput screening, surprisingly few molecules make it through the drug development process. While the reasons are debated, it is certain that many new chemical entities (NCEs) suffer from recurring problems that hinder development— low water solubility, instability, or inadequate pharmacokinetics. An estimated 43% of NCEs are poorly water-soluble.

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  • The traditional direct marketing paradigm implicitly assumes that there is no possibility of a customer purchasing the product unless he receives the direct promotion. In real business environments, however, there are “voluntary buyers” who will make the purchase even without marketing contact. While no direct promotion is needed for voluntary buyers, the traditional response-driven paradigm tends to target such customers. In this thesis, the traditional paradigm is examined in detail. We argue that it cannot maximize the net profit.

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  • Introduction: Pyrethroids are the general term for insecticide pyrethrins and their analogs (cinerins and jasmolins) being included in the flowers of pyrethrum or chrysanthemum. Trace concentrations of pyrethroids exert rapid toxic effects on insects, but are rapidly metabolized for detoxification in warm-blooded animals; they are insecticides with very high safety for humans. On the basis of clarification of chemical structures of the effective components of the pyrethrum, many of new synthetic pyrethroids were developed.

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  • This collection of essays demonstrates the international scope of history of nursing scholarship today, encompassing studies from Japan, New Zealand, South Africa, Canada and Europe. The authors examine the social and ethical issues which challenge nurses and midwives in different cultures; the transcultural issues which arise when carers move from one culture to another; and the process of professionalization for women over three centuries. The book highlights the significance of nursing in the history of womenʼs lives and work....

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  • This is the first in a series of guides to help nonprofit organizations that wish to introduce or improve their efforts to focus on the results of their services. The nonprofit sector is being increasingly pressured to provide evidence that its resources have improved the lives of clients, regardless of the size of the organization. Even without such pressure, nonprofit organizations should operate and manage those resources in a way that maximizes effectiveness in helping clients. This is not a new philosophy for nonprofit organizations.

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  • Despite the advances in the development of new drugs, a drug may never reach the target organ, or it may be difficult to achieve the necessary level of drug in the body. Large doses can result in serious side effects, and can harm normal cells and organs as well as diseased cells. Hence controlled release and the targeting of delivery systems must evolve in parallel to drug research.

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  • On September 1st , Switzerland announced it was extending a deadline for meeting its targets for reducing noise from road traffic. A new amendment to a federal ordinance on noise pollution will give national and local authorities until 2015 to install noise-reduction barriers along highways and until 2018 to install similar barriers along other major roads. The barriers were originally due to be in place by March 2002, under the 1986 federal ordinance. However, only around 30 percent of the roads targeted for remedial measures had barriers installed by that date.

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