Novel pharmaceuticals

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  • International Tables for Crystallography, Volume F, Crystal- lography of Biological Macromolecules, was commissioned by the International Union of Crystallography (IUCr) in recognition of the extraordinary contributions that knowledge of macro- molecular structure has made, and will make, to the analysis of biological systems, from enzyme catalysis to the workings of a whole cell.

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  • Aloe arborescensis a medicinal plant rich in aromatic polyketides, such as pharmaceutically important aloenin (hexaketide), aloesin (heptaketide) and barbaloin (octaketide). Three novel type III polyketide synthases (PKS3, PKS4 and PKS5) were cloned and sequenced from the aloe plant by cDNA library screening.

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  • of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, 986025 Nebraska Medical Center, COP 3026, Omaha, NE 68198-6025, USA 2Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, 30 South 2000 East, Salt Lake City, UT 84112, USA 3Department of Radiology/Radiobiology Division, University of Utah, 729 Arapeen Dr., Salt Lake City, UT 84108, USA 4Washington University in St. Louis, 6515 Wydown Blvd., Campus Box 3519, St.

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  • Lipases find promising applications in organic chemical processing, detergent formula- tions, synthesis of biosurfactants, the oleochemical industry, the dairy industry, the agro- chemical industry, paper manufacture, nutrition, cosmetics, and pharmaceutical processing. Development of lipase-based technologies for the synthesis of novel compounds is rapidly expanding the uses of these enzymes (Liese et al., 2000). One limiting factor is a shortage of lipases having the specific required processing characteristics.

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  • We have come so far so fast in understanding RNA interference (RNAi) and its central role in biology. Rarely has a novel mechanism in molecular genetics had such broad implications, ranging from gene therapy and drug discovery to our very understanding of what the word ‘gene’ means. Every major pharmaceutical company has a substantial effort now in RNAi technology, and among the smaller biotechnology companies RNAi is the mainstay of several, with

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