Ns-3 simulation

In this article, we performed hundred nanosecond molecular dynamics simulation and molecular docking of the NS3 helicase of ZIKV with 1,4-benzothiazine derivatives. The root mean square deviation (RMSD) analyses showed the stability of the NS3 helicase.

8p vijiraiya2711 27-05-2020 13 0   Download

NS4A is a non-structural multi-tasking small peptide that is essential for HCV maturation and replication. The central odd-numbered hydrophobic residues of NS4A (Val-23‘ to Leu-31‘)i are essential for activating NS3 upon NS3/4A protease complex formation. This study aims to design new specific allosteric NS3/4A protease inhibitors by mutating Val-23‘, Ile-25‘, and Ile-29‘ into bulkier amino acids. Pep-15, a synthetic peptide, showed higher binding affinity towards HCV-NS3 subtype-4 than native NS4A. The Kd of Pep-15 (80.0 ± 8.0 nM) was twice as high as that of native NS4A (169 ± 37 nM).

9p partimesinhvien 08-05-2020 13 1   Download

To achieve the goal, different performance metrics have been analyzed such as throughput, packet delivery ratio (PDR), loss packet ratio (LPR) and end to end delay (End to End) by varying packet interval time, packet size and number of nodes through network simulator NS3 for wireless sensor network with a practical wildlife scenario.

7p blossom162 31-03-2019 24 0   Download