Nuclear pore

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  • The nuclear pore complex (NPC) is the only gateway for molecular traf-ficking across the nuclear envelope. The NPC is not merely a static nuclear-cytoplasmic transport gate; the functional analysis of nucleoporins has revealed dynamic features of the NPC in various cellular functions, such as mitotic spindle formation and protein modification.

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: The two tempos of nuclear pore complex evolution: highly adapting proteins in an ancient frozen structure ...

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  • The nuclear envelope (NE) is composed of inner and outer nuclear mem-branes (INM and ONM, respectively), nuclear pore complexes and an underlying mesh like supportive structure – the lamina. It has long been known that heterochromatin clusters at the nuclear periphery adjacent to the nuclear lamina, hinting that proteins of the lamina may participate in regulation of gene expression.

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  • Importinamediates the nuclear import of proteins through nuclear pore complexes in eukaryotic cells, and is common to all eukaryotes. Previous reports identified at least six importinafamily genes in mice. Although these isoforms show differential binding to various import cargoes in vitro, the in vivo physiological roles of these mammalian importina isoforms remain unknown.

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  • Genetic origins of amino acids 1.1 Constituents and organisation of DNA DNA (deoxyribonucleic acid) is the genetic coding scheme used by all living organisms to pass on the hereditary programme to the next generation. DNA consists of two cross-linked polynucleotide chains, having an overall length of about 2 metres, which, for eukaryotes, is stored within the nucleus of a cell. The nucleus occupies about 10% of the cell volume and is isolated from the cytoplasm by the nuclear envelope, which consists of inner and outer bi-layer lipid membranes.

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