Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Nucleotide diversity and linkage disequilibrium in 11 expressed resistance candidate genes in Lolium perenne
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: High levels of nucleotide diversity and fast decline of linkage disequilibrium in rye (Secale cereale L.) genes involved in frost response
had great diffi culty fi nding a title for this book. For long, the working title was
Genetic Variation and Extinction. However, this title implies a causal and simple
relationship between genetic variation and extinction. I do think that the study
of genetic variation is extremely important for conservation biology but, as will
become apparent while reading the text, I am not as sure that this relationship is
as simple and straightforward as I thought when I began this voyage.
Nucleotide hydrolases are known to hydrolyze not only noncanonical
dNTPs to reduce the risk of mutation, but also canonical dNTPs to main-tain the dNTP concentrations in the cell. dGTP triphosphohydrolase from
Escherichia coliis known as an enzyme that hydrolyzes dGTP.
The prokaryotic genomes, for which complete nucleotide sequences are
available, always contain at least one RNase H gene, indicating that
RNase H is ubiquitous in all prokaryotic cells. Coupled with its unique
substrate specificity, the enzyme has been expected to play crucial roles in
the biochemical processes associated with DNA replication, gene expression
and DNA repair.
MicroRNAs (miRNAs) are small, noncoding RNAs of 18–25 nucleotides
that are generally believed to either block the translation or induce the deg-radation of target mRNA. miRNAs have been shown to play fundamental
roles in diverse biological and pathological processes, including cell prolif-eration, differentiation, apoptosis and carcinogenesis.
Ribonucleotide reduction, the unique step in the pathway to DNA synthe-sis, is catalyzed by enzymes via radical-dependent redox chemistry involv-ing an array of diverse metallocofactors. The nucleotide reduction gene
(nrdF) encoding the metallocofactor containing small subunit (R2F) of the
Corynebacterium ammoniagenesribonucleotide reductase was reintroduced
into strain C.