Nucleotide levels

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  • Cyclophilin D was recently shown to bind to and decrease the activity of F0F1 -ATP synthase in submitochondrial particles and permeabilized mito-chondria [Giorgio Vet al. (2009) J Biol Chem, 284, 33982–33988]. Cyclo-philin D binding decreased both ATP synthesis and hydrolysis rates.

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  • This is a dangerous combination. The persistence and mobility of POPs means that they are literally everywhere in the world, even in the Arctic,Antarctica, and remote Pacific islands. Their attraction to fatty tissue, known as "bioaccumulation", means that even though a poison is first dispersed widely and thinly it gradually starts to concentrate as organisms consume other organisms as they move up the food chain.

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Methylation levels of the “long interspersed nucleotide element-1” repetitive sequences predict survival of melanoma patients

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  • The activity of NTPDase (EC, apyrase, CD39) was verified in plate-lets from patients with increasing cholesterol levels. A possible association between cholesterol levels and inflammatory markers, such as oxidized low-density lipoprotein, highly sensitive C-reactive protein and oxidized low-density lipoprotein autoantibodies, was also investigated.

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  • On a regional level, a high percentage of respondents felt that social media could be an empowering tool for women, enhancing their participation in several facets of their lives, including the legal (by promoting women’s rights), economic (enhancing entrepreneurial and employment opportunities), political (increased political participation), and social (through self-expression and promoting social change) aspects (see Figure 9).

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: High levels of nucleotide diversity and fast decline of linkage disequilibrium in rye (Secale cereale L.) genes involved in frost response

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  • Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Methylation levels of the “long interspersed nucleotide element-1” repetitive sequences predict survival of melanoma patients

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  • Donovanosis is a chronic, progressively destructive bacterial infection of the genital region that is generally regarded as sexually transmitted (see "Epidemiology," below). The disease has been known by many other names, the most common of which are granuloma inguinale and granuloma venereum. Etiology Donovanosis is caused by Klebsiella granulomatis (formerly known as Calymmatobacterium granulomatis), an intracellular, gram-negative, pleomorphic, encapsulated (when mature) bacterium measuring 1.5 by 0.7 µm. K.

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  • Volkensin, a type 2 ribosome-inactivating protein from the roots of Adenia volkensiiHarms (kilyambiti plant) was characterized both at the protein and nucleotide level by direct amino acid sequencing and cloning of the gene enco-ding the protein. Gene sequence analysis revealed that vol-kensin is encoded by a 1569-bp ORF (523 amino acid residues) without introns, withan internal linker sequence of 45 bp.

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  • As Vietnam has rich resources of local chicken breeds, some of them are known having a certain level of infectious disease resistance. Knowledge of the single-nucleotide polymorphism in exon 14 of the chicken Mx gene will facilitate further researches on the resistant activity of Mx gene and its use for breeding of influenza virus resistant chicken varieties. This study aimed to investigate the exon 14 polymorphisms of the Mx gene in some representative indigenous chicken breeds collected from different locals in Vietnam.

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  • Bank balance sheets are highly leveraged. The average ratio of total assets to shareholders’ capital is about three for non-financial companies, but it is six times that figure for banking firms. 2 From the shareholders’ perspective, higher bank leverage boosts the return on equity for any given level of bank profits. This, however, imposes higher risk, since leverage also increases the volatility of that return. Indeed, in most advanced economies bank equity prices have been more volatile than those of non-financial companies in the last four decades.

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  • Thanks are offered to my colleagues in the UN Millennium Project Secre- tariat for the example they set in their work and for their openness to recogniz- ing and incorporating SRH in their work. Prime recognition is given to the leadership, inspiration and dedication of Jeffrey Sachs. At the Policy Advisor level, special thanks are due to Chandrika Bahadur, Eric Kashambuzi, Mar- garet Kruk, John McArthur, Joanna Rubinstein and Guido Schmidt-Traub.

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  • WhenSaccharomyces cerevisiaecells, grown in galactose, glucose or mannose, were treated with 1.5 mMhydrogen peroxide (H2O2) for 30 min, an important decrease in the ATP, and a less extensive decrease in the GTP, CTP, UTP and ADP-ribose levels was estimated. Concomitantly a net increase in the inosine levels was observed. Treatment with 83mMmenadionepromoted theappearanceof acompound similar to adenosine but no appreciable changes in the nucleotide content of yeast cells, grown either in glucose or galactose....

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  • Principles of Genetic Variation and Human Traits (See also Chaps. 62 and 64) Variants in the human genome resulting in variation in level of expression or function of molecules important for pharmacokinetics and pharmacodynamics are increasingly recognized. These may be mutations (very rare variants, often associated with disease) or polymorphisms, variants that are much more common in a population. Variants may occur at a single nucleotide [known as single nucleotide polymorphism (SNP)] or involve insertion or deletion of one or more nucleotides.

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  • The human genome is largely made of complex sequences evolved over time due to replication,mutations and insertion of foreign DNA. Based on the nucleotide distribution and functional significance, the genome has been categorized into different block of sequences, namely genes or coding and non-coding regions. A special type of sequence located near genes, in relation to spread of DNA methylation and dinucleotide frequencies are the CpG islands1.

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  • The transfer of genetic information from the level of the nucleic acid sequence of a gene to the level of the amino acid sequence of a protein or to the nucleotide sequence of RNA is termed gene expression. The entire process of gene expression in eucaryotes includes the following steps:

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  • This study characterized the human apolipoprotein H [APOH; b2-glycopro-tein I (b2GPI)] promoter and its variants byin vitro functional experiments and investigated their relationship with human plasmab2GPI levels. We examined the individual effects of 12 APOHpromoter single nucleotide polymorphisms in the 5¢ flanking region ofAPOH(1.4 kb) on luciferase activity in COS-1 cells and HepG2 cells and their impact on plasma...

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  • With the increasing complexity of modern medicine, we now have literally thousands of possible investigative techniques at our disposal. We are able to examine our patient’s serum and every other body fluid down to the level of individual nucleotides, as well as being able to perform precise imaging through CT, MRI and other imaging technologies. The problem we have all faced, especially as senior medical students or junior doctors is: which test should we use in a given setting? What hazards are associated with the tests?...

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