Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Experimental observations of rapid Maize streak virus evolution reveal a strand-specific nucleotide substitution bias
Nucleotide variations that do not alter the protein-coding sequence have
been routinely considered as neutral. In light of the developments we have
seen over the last decade or so in the RNA processing and translational
field, it would be proper when assessing these variants to ask if this change
is neutral, good or bad.
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Nitric oxide (NO), the principal endogenous ligand for soluble guanylate cyclase (sGC), stimulates that enzyme and accumulation of intracellular cGMP, which mediates many of the (patho) physiological eﬀects of NO. Previous studies demonstrated that 2-substituted adenine nucleotides, including 2-methylthioATP (2MeSATP) and 2-chloroATP (2ClATP), allosterically inhibit guanylate cyclase C, the membrane-bound receptor for the Escherichia coli heatstable enterotoxin in the intestine. The present study examined the eﬀects of 2-substituted adenine nucleotides on crude and puriﬁed sGC. ...
The book updated material on Infrared Spectroscopy and Nuclear Magnetic Resonance of amines, aldehydes/ketones, and carboxylic acid derivatives. Updated information on DNA sequencing (the process of determination of the precise sequence of nucleotides within a DNA molecule) and DNA synthesis.
We purified pancreatic deoxyribonuclease I (DNase I) from
the shark Heterodontus japonicususing three-step column
chromatography. Although its enzymatic properties resem-bled those of other vertebrateDNases I, sharkDNase I was
unique inbeingabasicprotein.Full-lengthcDNAs encoding
theDNases I of two shark species,H. japonicusandTriakis
scyllia, were constructed from their total pancreatic RNAs
Fluorescent and colored trinitrophenylated (TNP) analogs
of ATP and GTP can interact with nucleotide-requiring
enzymes and proteins as a substitute for the parent nucleo-tide. These analogs have strong binding affinities for most
nucleotide-requiring systems. Their bindings are easily
detected by absorption and fluorescence changes in the visi-ble region.Recent years have seendramatic developments in
the application of the TNP nucleotide analogs as spectro-scopic probes for the study on the nucleotide-interacting
properties of various enzymes and proteins including their