Opioid dependence

Xem 1-6 trên 6 kết quả Opioid dependence
  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Non-medical use of opioids among HIV-infected opioid dependent individuals on opioid maintenance treatment: the need for a more comprehensive approach

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  • This manual has been prepared by Corrado Barbui, Andreas Cipriani (both from the University of Verona, Verona, Italy) and Shekhar Saxena (WHO, Geneva). These contributors have reported no conflict of interest related to this work. Overall vision and supervision for this work was provided by Michele Tansella (University of Verona, Verona, Italy) and Benedetto Saraceno (WHO, Geneva). José Bertolote, Tarun Dua, Mark van Ommeren, Michelle Funk, (all from WHO, Geneva) provided inputs at various stages of the project.

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  • Extracellular signal-regulated kinases (ERKs) have been shown to be acti-vated by opioids and functionally linked to addiction. Morphine-associated changes in ERK activity seem to be the characteristic features of opioid action. In this study, we observed a rapid and severe increase in ERK1⁄2 activity after a 5 min morphine treatment of HEK-MOR cells (transfected with the ratl-opioid receptor MOR1) expressing l-opioid receptor.

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  • Opioid analgesics such as morphine and meperidine have been used to control moderate to severe pain for many years. However, these opioids have many side effects, including the development of tolerance and dependence after long-term use, which has limited their clinical use. We previously reported that mutations in the muopioid receptors (MOR) S196L and S196A rendered them responsive to the opioid antagonist naloxone without altering the agonist phenotype. In MORS196A knock-in mice, naloxone and naltrexone were antinociceptive but did not cause tolerance or physical dependence.

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  • Another CAM and TM modality that has considerable accept- ance is acupuncture.Many pain management clinics, hospitals, and academic centers in the West now provide acupuncture services, and some insurance companies reimburse for acupuncture services. Rigorous clinical trials have demonstra- tive positive efficacy in two areas: (a) management of postop- erative nausea and emesis (Shen and others 2000) and (b) ame- lioration of the pain of chronic osteoarthritis (Ezzo and others 2001; Soeken 2004; Tukmachi and others 2004).

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  • The gene encoding the mu-opioid receptor (OPRM1) has been reported to associate with a range of substance dependence and HRH2 is the gene coding histamine H2 receptor, the site of action for various compounds, e.g. amitriptiline and mianserin, used in the treatment of psychiatric disorders. Both OPRM1and HRH2 genes contain some single nucleotide polymorphisms (SNPs), including +118A/G in OPRM1 and +398T/C in HRH2, which were reported to change in protein sequences and result in affecting the therapeutic response. ...

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