Optimal medical therapy

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  • In patients with stable coronary artery disease, it remains unclear whether an initial management strategy of percutaneous coronary intervention (PCI) with intensive pharmacologic therapy and lifestyle intervention (optimal medical therapy) is superior to optimal medical therapy alone in reducing the risk of cardiovascular events. Methods We conducted a randomized trial involving 2287 patients who had objective evidence of myocardial ischemia and significant coronary artery disease at 50 U.S. and Canadian centers....

    pdf15p muakhuya 07-07-2012 25 3   Download

  • Over the past decade, treatment of neovascular age-related macular degeneration has evolved from overall retinal ablation to more targeted and retinal-sparing therapy, beginning with the advent of photodynamic therapy and continuing with the development of inhibitors to vascular endothelial growth factor (VEGF). This article summarizes the key clinical trials with photodynamic and anti- VEGF therapies to provide insight into and a framework around which we can choose the optimal treatments (including dosing) for our patients....

    pdf0p ozon_ozon 03-05-2012 32 5   Download

  • d-Amino acid oxidase (DAAO) has recently become of interest as a biocat-alyst for industrial applications and for therapeutic treatments. It has been used in gene-directed enzyme prodrug therapies, in which its production of H2O2 in tumor cells can be regulated by administration of substrate. This approach is limited by the locally low O2 concentration and the high Km for this substrate.

    pdf12p vinaphone15 25-02-2013 6 1   Download

  • Therefore, there is a critical window of opportunity to prevent under-nutrition – while the mother is pregnant and during child’s first two years of life – when proven nutrition interventions offer children the best chance to survive and reach optimal growth and development; after that window closes, the damage to children is largely irreparable.

    pdf44p nhamnhiqa 01-03-2013 23 1   Download

  • Upper respiratory tract infections and, especially, sinusitis are frequently encountered in the day-to-day practice of infectious disease specialists, allergists, pediatricians, otolaryngologists, internists, and family practitioners. The range of causative agents and available therapies and the constantly changing spectrum of antibiotic resistance can make it difficult to select the most appropriate course of treatment.

    pdf490p ozon_ozon 04-05-2012 51 19   Download

  • Acute emergencies in gastroenterology are extraordinarily severe conditions with high morbidity and mortality. Particularly severe diseases include acute pancreatitis, a difficult course of non-specific intestinal inflammations manifested by toxic colon or acute intestinal obstruction, and even acutely developed intestinal pseudo-obstruction (Ogilvie’s syndrome) or variceal and non-variceal bleeding into the gastrointestinal tract.

    pdf78p crazy_sms 07-05-2012 36 5   Download

  • Heat transport limitation in larger tissue may also affect survival. Due to the macroscopic size of tissue-engineered products and its finite thermal conductivity, there may be large thermal gradients from the surface to the interior of the samples. The presence of a thermal gradient during cooling and warming phases makes it difficult to choose optimal temperature change protocols for both surface and interior cells. Moreover, osmotic effects (water movement from inside-unfrozen cells to outside-frozen cells) during cooling, reduces cell survival.

    pdf218p kmkmkmkmkm 08-09-2012 13 4   Download

  • The physician is greatly challenged to provide optimal therapy for mycobacterial illnesses because of the increase in both drug-susceptible and multidrug-resistant tuberculosis; the increasing number of pathogenic nontuberculous mycobacteria (NTM); drug-related toxicities and drug-drug interactions (especially in patients who have AIDS, with their complex antiretroviral drug regimens); and the plethora of new antibiotics with antimycobacterial potential.

    pdf19p crazy_sms 08-05-2012 29 3   Download

  • The field of antiviral therapy—both the number of antiviral drugs and our understanding of their optimal use—continues to lag behind the field of antibacterial drug treatment, in which 70 years of experience have now been accumulated, but significant progress has been made in recent years on new drugs for several viral infections. The development of antiviral drugs poses several challenges. Viruses replicate intracellularly and often employ host cell enzymes, macromolecules, and organelles for synthesis of viral particles.

    pdf34p crazy_sms 09-05-2012 21 2   Download

  • A similar effort may well be in order targeting the gay and bisexual men who are most at risk, particularly those who are living with HIV. Further research is needed to determine the prevalence and incidence of ASIL in the general population of gay and bisexual men outside of major urban centers. Programs are needed to train colposcopists in the skills of identifying and biopsying ASIL; training of colorectal surgeons is needed to optimize identification and treat- ment of ASIL.

    pdf16p taisaokhongthedung 09-01-2013 22 1   Download

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