Oxidative damage

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  • Cysteine plays a number of important roles in protecting the cell from oxidative damage through its thiol functional group. These defensive func-tions are generally considered to be carried out by the low molecular weight thiol glutathione and by cysteine residues in the active sites of pro-teins such as thioredoxin and peroxiredoxin.

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Extracellular mitochondrial DNA and oxidatively damaged DNA in synovial fluid of patients with rheumatoid arthritis...

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Neuronal oxidative damage and dendritic degeneration following activation of CD14-dependent innate immune response in vivo

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Ethanol extract of Scutellaria baicalensis Georgi prevents oxidative damage and neuroinflammation and memorial impairments in artificial senescense mice

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  • The process likely begins with the development of defects in the supply of cholesterol and fats to neurons, progressing to extensive oxidative damage, mitochondrial defects, and a shift of metabolism towards utilizing sources other than glucose and minimizing mito- chondrial involvement. In the end stage, neurons can no longer transmit signals effectively, and apoptosis is the best option to avoid damaging neighboring cells. A crucial role is played by astrocytes, the glial cells that supply cholesterol and fats to neurons.

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  • Following their lipophilicity, it is more plausible that vitamin E and ß-carotene cooperate to protect membranes and lipoproteins from oxidative damages. Of course, as all antioxidants, vitamin E exerts other biological functions that are independent from its antioxidant properties, including modulation of cellular signaling, gene expression, immune response, and many more. However, as opposed to other vitamins, lack of vitamin E results in rather unspecific symptoms, also highlighting that this vitamin is mainly needed for its antioxidant activity in vivo.

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  • The Nbs1 protein associates with Mre11 and Rad50 proteins to form the Mre11–Rad50–Nbs1 complex, which plays an important role in the intracellular signaling pathway activated in response to DNA damage. Mutations in the genes for each of these three components of the Mre11– Rad50–Nbs1 complex result in human diseases characterized by genomic instability.

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  • Ionizing radiation, oxidative stress and endogenous DNA-damage pro-cessing can result in a variety of single-strand breaks with modified 5¢ and⁄or 3¢ ends. These are thought to be one of the most persistent forms of DNA damage and may threaten cell survival. This study addresses the mechanism involved in recognition and processing of DNA strand breaks containing modified 3¢ ends.

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  • The ÔMediterraneanÕ variant of glucose-6-phosphate dehydrogenase (G6PD) deficiency is due to the C563CT point mutation, leading to replacement of Ser with Phe at position 188, resulting in acute haemolysis triggered by oxidants. Previous work has shown increased formation of altered aspartate residues in membrane proteins during cell ageing and in response to oxidative stress in normal erythrocytes. These abnormal residues are specifically recognized by the repair enzyme L-isoaspartate (D-aspartate) protein O-methyltransferase (PCMT; EC ...

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  • The body is made up of trillions of living cells. Normal body cells grow, divide, and die in an orderly way. During the early years of a person's life, normal cells divide faster to allow the person to grow. After the person becomes an adult, most cells divide only to replace worn-out, damaged, or dying cells. Cancer begins when cells in a part of the body start to grow out of control. There are many kinds of cancer, but they all start because of this out-of-control growth of abnormal cells. Cancer cell growth is different from normal cell growth. Instead...

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  • Homocysteine (Hcy) is anonprotein-forming sulphur amino acid that plays an important role in remethylation and trans-sulphuration processes. In recent years, it has been suggested that increased levels of plasma Hcy may play a role in the pathogenesis of various diseases, particularly at the cardiovascular level. The pathogenic mechanism of hyperhomocysteinemia, however, has not been clarified.

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  • There is strong evidence thatb-amyloid (Ab) causes oxidative stress and induces mitochondrial dysfunction in the pathogenesis of Alzheimer’s dis-ease. Mitochondrial transcription factor A (Tfam) has multiple roles in the maintenance of mtDNA. To study the protective roles of Tfam against amyloid neurotoxicity, we established SH-SY5Y cell lines stably over-expressing Tfam and exposed them to 10lmAb1-42 for 24 h.

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  • Aging is accompanied by gradual cellular dysfunction associated with an accumulation of damaged proteins, particularly via oxidative processes. This cellular dysfunction has been attributed, at least in part, to impair-ment of mitochondrial function as this organelle is both a major source of oxidants and a target for their damaging effects, which can result in a reduction of energy production, thereby compromising cell function.

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  • Content marketing is all the rage. In a distracted world, where consumers are bombarded with advertising and overwhelmed by media and device choices, brands are searching for a new ways to connect—ideally over the long term. And many marketers are turning to content with varying degrees of success.

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  • While the structure of the dairy processing industry has improved dramatically, milk collection and distribution is fragmented compared to systems found in other countries. There is a need to improve the supply chain from farmer to consumer in Pakistan. There is very limited data available on the routes to market or the distribution channels employed in Pakistan. Most of the milk produced in the farms is consumed at the household level.

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  • The ability of privately insured individuals to obtain faster access to care is significantly influenced by governmental policies and approaches. Allowing public providers to treat both private and public patients and to receive different remuneration levels for these separate activities can encourage their involvement in the private sector. This spurs the development of a market for PHI products offering access to more timely elective care in the private sector.

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  • Lung protection strategy permising hypercapnia induces the development of cranial hyperemia and hypertension. On the other hand, “aggressive” ventilation with high tidal volume may aggravate lung injury and provoke ventilator-associated lung damage(9). In mechanical ventilation treatment, PEEP improves oxygenation by recruitment of atelectatic alveolar units, improving FRC and preventing atelectrauma. Also it may have detrimental neurologic effects in certain clinical circumstances(10).

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  • The production of free radicals (ROS) is an unavoidable consequence of life in an aerobic environment. Free radicals produced from the metabolic activities of oxygen attack biological membranes and lipoproteins via oxidation in a process called lipid perioxidation. This attack damages cells and lipids often in a chain reaction with carbon-based molecules such as polyunsaturated fatty acids (PUFA) in a reaction with molecular oxygen. This creates oxidative stress and damage to tissues. Free radicals also damage chromosomal DNA.

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  • Despite the prominence of gender issues in the IADGs, effectiveness of development cooperation has not focussed enough on outcomes of gender equality and women’s rights in terms of either the inclusion of indicators tracking the focus of development cooperation on gender equality or the participation of women’s organisations in initiatives to hold actors to account. 2012 analysis conducted for the DCF shows that aid/partnership policies, targets and mutual accountability processes do not focus adequately on the gender impact of development cooperation.

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  • B2B Content Marketing: 2012 Benchmarks, Budgets and Trends is the second annual survey about content marketing in the business-to-business (B2B) space. We surveyed 1,092 marketers from diverse industries and a wide range of company sizes in August 2011. Last year, the results revealed content marketing is a well-established, core marketing strategy in the B2B marketplace. However, while many marketers were using these tactics, they were uncertain about their effectiveness.

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