The 3 billion base pair sequence of the human genome is now available, and attention is focusing on annotating it to extract biological meaning. I will discuss what we have obtained, and the methods that are being used to analyse biological sequences. In particular I will discuss approaches using stochastic grammars analogous to those used in computational linguistics, both for gene finding and protein family classification.
Under explicit diophantine conditions on (α, β) ∈ R2 , we prove that the local two-point correlations of the sequence given by the values (m − α)2 + (n−β)2 , with (m, n) ∈ Z2 , are those of a Poisson process. This partly conﬁrms a conjecture of Berry and Tabor  on spectral statistics of quantized integrable systems, and also establishes a particular case of the quantitative version of the Oppenheim conjecture for inhomogeneous quadratic forms of signature (2,2). The proof uses theta sums and Ratner’s classiﬁcation of measures invariant under unipotent ﬂows. ...
A primer, we are told by the Shorter Oxford English Dictionary
(Onions, 1980:1,670), is “a small introductory book on any subject.” Some
ten years ago, amidst a mixture of encouragement and pestering by colleagues,
I set about writing a primer in conversation analysis. I had been
teaching a two-term course called “Conversational Structures” to classes
of both undergraduate and graduate students for over twenty years by then,
and more abbreviated courses to one or the other of these cohorts for several
years before that.
This paper presents a translation model that is based on tree sequence alignment, where a tree sequence refers to a single sequence of subtrees that covers a phrase. The model leverages on the strengths of both phrase-based and linguistically syntax-based method. It automatically learns aligned tree sequence pairs with mapping probabilities from word-aligned biparsed parallel texts.
For a transversal pair of closed Lagrangian submanifolds L, L of a symplectic manifold M such that π1 (L) = π1 (L ) = 0 = c1 |π2 (M ) = ω|π2 (M ) and for a generic almost complex structure J, we construct an invariant with a high homotopical content which consists in the pages of order ≥ 2 of a spectral sequence whose diﬀerentials provide an algebraic measure of the highdimensional moduli spaces of pseudo-holomorpic strips of ﬁnite energy that join L and L . When L and L are Hamiltonian isotopic, we show that the pages...
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: ChIA-PET tool for comprehensive chromatin interaction analysis with paired-end tag sequencing...
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài:
Research Article Optimized Punctured ZCZ Sequence-Pair Set: Design, Analysis, and Application to Radar System
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: FusionSeq: a modular framework for finding gene fusions by analyzing paired-end RNA-sequencing data...
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Identification of fusion genes in breast cancer by paired-end RNA-sequencing...
Concept of hybrid molecules:
When double strand DNA is steamed to a temperature
exceed the melting temperature (Tm), it will separate
into 2 single strands DNA due to breaks of H bonds. If
the reaction temperature is then decreased slowly plus
other appropriate experimental conditions, these
ssDNA will pair again. This phenomenon is called the
hybridization of molecules.
Characteristic of the hybrid molecules: Specificity, the
re-pairing occurs only between two complementary
Telomerase DNA polymerase is unable to replicate the tips of chromosomes, resulting in the loss of DNA at the specialized ends of chromosomes (called telomeres) with each replication cycle. At birth, human telomeres are 15- to 20-kb pairs long and are composed of tandem repeats of a six-nucleotide sequence (TTAGGG) that associate with specialized telomere-binding proteins to form a T-loop structure that protects the ends of chromosomes from being mistakenly recognized as damaged.
Different types of mutation can vary in size, from structural variants to single base-pair substitutions, but what they all have in common is that their nature, size and location are often determined either by specific characteristics of the local DNA sequence environment or by higher order features of the genomic architecture. The genomes of higher organisms are now known to contain "pervasive architectural flaws" in that certain DNA sequences are inherently mutation prone by virtue of their base composition, sequence repetitivity and/or epigenetic modification....
We now turn our attention to Double Diamond Skis, a company that manufactures
a high-performance deep-powder ski, and that uses process costing to determine its unit
product costs. The company’s production process is illustrated in Exhibit 4–4 . Skis go
through a sequence of five processing departments, starting with the Shaping and Milling
Department and ending with the Finishing and Pairing Department.
Convolutional codes are linear.
Therefore, the Hamming distance between any pair of code sequences corresponds to the Hamming
distance between the allzero
code sequence and some nonzero code sequence. The nonzero sequence of minimum Hamming weight diverges from the allzero
path at some point and
remerges with the allzero
path at some later point
Disulfide pairings and active site residues are highly conserved in secretory
phospholipases A2 (PLA2s). However, secretory PLA2
s of marine inverte-brates display some distinctive structural features. In this study, we report
the isolation and characterization of a PLA2 from the northern Pacific sea
anemone,Urticina crassicornis(UcPLA2), containing a C27N substitution
and a truncated C-terminal sequence.
A tree is any set of points and any set of pairs distinct vertices such that there is a sequence of edges from any vertex to any other, and there are no circuits, that is, no paths starting from a vertex and returning to the same vertex.
The expansion of DNA repeat sequences is associated with many genetic
diseases in humans. Simple bulge DNA structures have been implicated as
intermediates in DNA slippage within the DNA repeat regions. To probe
the possible role of bulged structures in DNA slippage, we designed and
synthesized a pair of simple chiral spirocyclic compounds [Xi Z, Ouyang D
& Mu HT (2006)Bioorg Med Chem Lett16, 1180–1184],
DNA-binding sites for SYCRP1, which is a regulatory protein of the
cyanobacterium Synechocystissp. PCC6803, were predicted for the whole
genome sequence by estimating changes in the binding free energy
) for SYCRP1 for those sites. The DDG
values were calculated
by summingDDGvalues derived from systematic single base-pair substitu-tion experiments (symmetrical and cooperative binding model).
The conduction of protons through human Nox2 has pre-viously been shown to be dependent upon His115. Align-ment of sequences for both animal and plant Nox proteins
indicated that histidines 115 and 119 are both highly con-served, while His111 was conserved among animal homo-logues of Nox1–4. To investigate the possible role that these
histidine residues might play in the conduction of protons
through Nox2, we have introduced both paired and single
mutations into these histidine residues.
We report on a sequence-specific double-stranded DNA labelling strategy
in which a stem–loop triplex forming oligonucleotide (TFO) is able to
encircle its DNA target. Ligation of this TFO to either a short hairpin
oligonucleotide or a long double-stranded DNA fragment leads to the for-mation of a topological complex. This process requires the hybridization of
both extremities of the TFO to each other on a few base pairs. The effects
of different factors on the formation of these complexes have been investi-gated. ...