Pancreatic ductal

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  • Pancreatic cancer is one of the most fatal human malignancies with extremely poor prognosis making it the fourth leading cause of cancer-related deaths in the United States. The molecular mechanisms of pancreatic carcinogenesis are not well understood. The major focus of these two books is towards the understanding of the basic biology of pancreatic carcinogenesis, identification of newer molecular targets and the development of adjuvant and neoadjuvant therapies.

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  • Harrison's Internal Medicine Chapter 89. Pancreatic Cancer Pancreatic Cancer: Introduction Over 90% of pancreatic cancers are ductal adenocarcinomas of the exocrine pancreas. These tumors occur twice as frequently in the pancreatic head compared to the rest of the organ, and tend to be aggressive, often presenting when locally inoperable or after distal metastases have occurred. Patients with pancreatic cancer have a poor prognosis, with a 5-year survival of only 5%. The discussion of pancreatic cancer here will be limited to ductal adenocarcinomas.

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  • Background: Pancreatic cancer is one of the most aggressive human tumors due to its high potential of local invasion and metastasis. The aim of this study was to characterize the membrane proteomes of pancreatic ductal adenocarcinoma (PDAC) cells of primary and metastatic origins, and to identify potential target proteins related to metastasis of pancreatic cancer.

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  • The grim picture of women’s health, including maternal mortality and HIV, has many causal factors, and solutions are to be found in multiple sectors. However, many of these solutions are mediated through and require the presence of strong and effective local health systems. This level of care, defined in many countries as the “district health system,” embraces the contin- uum of care reaching from the household/community level up through the first referral facility level, to the district hospital.

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  • In response to various pressures, businesses have begun to report externally on their environmental policy and performance. The significance of such external reporting depends on the extent of changes in management culture and systems and on how new measures influence management decisions. The 'greening of accountancy' involves a reappraisal of how to identify and measure the relevant costs of processes and products (such as 'Total Cost Assessment') and a redesign of incentive mechanisms.

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  • At the beginning of the 21st century, medicine is increasingly based on understanding the functions of genes and the molecular mechanisms of diseases. In pancreatology, the understanding of functions and dysfunctions of the exocrine and endocrine pancreas is derived from molecular biological data on the actions of compounds in subcellular compartments and intracellular transcription pathways.

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  • Since the 1990s, Pollution Probe has focused its programmes on issues related to air pollution, water pollution and human health, including a major programme to remove human sources of mercury from the environment. Pollution Probe’s scope has recently expanded to new concerns, including the unique risks that environmental contaminants pose to children, the health risks related to exposures within indoor environments, and the development of innovative tools for promoting responsible environmental behaviour.

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  • Ankylosing Spondylitis (AS) was first described possibly at the end of the XVII century by Buckley (1931) and Connor, but it was only recognized after the radiologic descriptions of Bechterew, Strumpell and Marie, during the XIX century. In 1964 the American Rheumatism Association classified AS as a distinct disease. About forty years ago (1973), Schlosstein and Brewerton published simultaneously but independently the association of AS with the Class I allele B*27.

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  • The concept of tissue engineering is to regenerate target tissue by mimicking the developmental or regenerative process of that tissue. Thus, it can be considered an ideal therapeutic option for treating various tissue defects. Tissue engineering of skin, cartilage, and bone has already been shown both feasible and effective in several clinical studies, and its efficacy has attracted significant attention from both patients and doctors.

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  • The most important investment strategy has to do with support for creative activity within communitie as it emerges in relatively organic ways. This has to b led in large part through the allocation of direct and flexible grant support for artists and cultural groups. This demand-oriented support would primarily be provided within neighborhoods, but could also consist of partnerships with citywide and regional organizations, particularly where there is the potenti to connect places to institutions and audiences that would not easily be involved otherwise.

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  • Normal cells are cohesive in nature but exfoliated when they attain maturation. During malignant conditions or during infection, the exfoliation becomes exaggerated and the epithelial cells show variation in morphology. Such exfoliated cells, when collected and appropriately stained, give information on the living epithelium from which they are derived. These characteristic cellular and nuclear appearances in cells thrown off from healthy epithelium, differ distinctly from those, derived from inflamed or malignant lesions.

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  • Destinations offer an amalgam of tourism products and services, which are consumed under the brand name of the destination. Leiper (1995, p.87) explains that destinations are places towards which people travel and where they choose to stay for a while in order to experience certain features or characteristics-a perceived attraction of some sort. Cooper et al (1998) define destinations as the focus of facilities and services designed to meet the needs of the tourists.

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  • It was this bit of commercial toss that moved me to cut the scene. You see, now I had the missing ingredient, the thing that took my mashup from something trite and obvious to something genuinely moving -- a flashback to happier, carefree times, before all the hairy bits got hairy, before the smoldering began in earnest. The fact that the commercial footage was way way down-rez from the other stuff actually made it better, because it would look like it came from an earlier era, a kind of home-film shakycam feel that I bumped up using a video-effects app I found on yet another dodgy...

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  • Over 90% of pancreatic cancers are ductal adenocarcinomas of the exocrine pancreas. These tumors occur twice as frequently in the pancreatic head compared to the rest of the organ, and tend to be aggressive, often presenting when locally inoperable or after distal metastases have occurred. Patients with pancreatic cancer have a poor prognosis, with a 5-year survival of only 5%. The discussion of pancreatic cancer here will be limited to ductal adenocarcinomas.

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  • The oviduct is an exquisitely designed organ that functions in picking-up ovulated oocytes, transporting gametes in opposite directions to the site of fertilization, providing a suitable environment for fertilization and early development, and transporting preimplantation embryos to the uterus. A variety of biological processes can be studied in oviducts making them an excellent model for toxicological studies.

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  • The following pages are devoted to a statistical analysis of the principal factors affecting credit risk. The information on which the study is based was obtained from a sample of 2,765 applications of persons to whom loans were granted. The data, secured through the cooperation of 21 large banks operating personal loan departments in 16 cities situated in ii states,1 are presented in a series of tables giving the distri- butions of good and of bad loans according to the several risk factors selected.

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  • Three features taken together distinguish federal funds from other money market instruments. First, they are short-term borrowings of immediately available money—funds which can be transferred between depository institutions within a single business day. In 1991, nearly three-quarters of federal funds were overnight borrowings. The remainder were longer maturity borrowings known as term federal funds. Second, federal funds can be borrowed by only those depository institutions that are required by the Monetary Control Act of 1980 to hold reserves with Federal Reserve Banks.

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  • In his opening address to the conference, Jon wood, who coordinates the research programme at the Institute, traced the origins of the conference to a series of exploratory conversations on the relationship between archaeology and contemporary art with independent curator Katy rochester. From the outset, wood, rochester and their colleagues in leeds sought proposals from archaeologists who were interested in sculpture and in sharing new ideas with sculpture historians.

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  • In addition to each of the individual barrier areas, an additional complication arises due to the large degree of interaction among the areas shown in Figure 6. For example, if we assume that altering the biological composition of a particu- lar source crop would be beneficial, then this may have consequences on the process required, the type and performance of materials to be utilized, the infra- structure required to support this use, and the scientific education of students who may be subsequently employed within such a system.

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  • This books highlights the methods and mechanisms by which epigenetics with a focus on DNA methylation can be studied and its impacts on health. In the first part, the first chapter focuses on the modeling and feedback dynamics of DNA methylation, discussing mechanisms and controlling factors as well as DNA sequences pattern analyses and histone modifications and their association with disease initiation. Most methods for detecting methylated-CpG islands rely on chemical conversion of DNA by treatment with bisulfite....

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