Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " A local glucose-and oxygen concentration-based insulin secretion model for pancreatic islets Peter Buchwald
Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Comparative study of endocrine cells in the principal pancreatic islets of two teleosts, Silurus asotus (Siluridae) and Siniperca scherzeri (Centropomidae)
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: "FEM-based oxygen consumption and cell viability models for avascular pancreatic islets
To gain better insight into the insulin secretory activity of
fetalbcells in response to glucose, the expression of glucose
transporter 2 (GLUT-2), glucokinase and mitochondrial
glycerol phosphate dehydrogenase (mGDH) were studied.
Expression ofGLUT-2mRNA and protein in pancreatic
islets and liver was signi®cantly lower in fetal and suckling
rats than in adult rats.
Harrison's Internal Medicine Chapter 89. Pancreatic Cancer
Pancreatic Cancer: Introduction
Over 90% of pancreatic cancers are ductal adenocarcinomas of the exocrine pancreas. These tumors occur twice as frequently in the pancreatic head compared to the rest of the organ, and tend to be aggressive, often presenting when locally inoperable or after distal metastases have occurred. Patients with pancreatic cancer have a poor prognosis, with a 5-year survival of only 5%. The discussion of pancreatic cancer here will be limited to ductal adenocarcinomas.
Human amylin is a small fibrillogenic protein that is the major constituent
of pancreatic islet amyloid, which occurs in most subjects with type 2 dia-betes. There is evidence that it can elicitin vitro apoptosis in isletb-cells,
but the physical properties that underpin its cytotoxicity have not been
Diabetes Mellitus The success of islet cell and pancreas transplantation provides proof of concept for a cell-based approach for type I diabetes. However, the demand for donor pancreata far exceeds the number available, and maintenance of long-term graft survival remains a problem. The search for a renewable source of stem cells capable of regenerating pancreatic islets has therefore been intensive.
Pancreatic βcell turnover occurs in the normal pancreas, although the source of the new βcells is controversial.
Rarely, corticotropin-releasing hormone (CRH) is produced by pancreatic islet tumors, SCLC, medullary thyroid cancer, carcinoids, or prostate cancer. When levels are high enough, CRH can cause pituitary corticotrope hyperplasia and Cushing's syndrome. Tumors that produce CRH sometimes also produce ACTH, raising the possibility of a paracrine mechanism for ACTH production.
A distinct mechanism for ACTH-independent Cushing's syndrome involves ectopic expression of various G protein–coupled receptors in the adrenal nodules.
MicroRNA mir-9 is speculated to be involved in insulin secretion because
of its ability to regulate exocytosis. Sirt1 is an NAD-dependent protein
deacetylase and a critical factor in the modulation of cellular responses to
altered metabolic flux. It has also been shown recently to control insulin
secretion from pancreaticb-islets.
Human amylin (hA) is a small fibrillogenic protein that is the major con-stituent of pancreatic islet amyloid, which occurs in most subjects with
type-2 diabetes mellitus (T2Dm). There is growing evidence that hA toxic-ity towards islet b-cells is responsible for their gradual loss of function in
T2Dm. Preventing hA-mediated cytotoxicity has been proposed as a route
to halt the progression of this disease, although this has not yet been dem-onstratedin vivo.
Liquid chromatography mass spectrometry (LC-MS) is a
valuable tool in the analysis of proteins and peptides.The
combination of LC-MS with different fragmentation
methods provides sequence information on components in
complex mixtures.In this work, on-line packed capillary
LC electrospray ionization Fourier transform ion cyclotron
resonance MS was combined with two complementary
fragmentation techniques, i.e.
Islet transplantation provides a promising cure for Type 1 diabetes; however it is limited by a shortage of pancreas donors. Bone marrow-derived multipotent mesenchymal stem cells (MSCs) offer renewable cells for generating insulin-producing cells (IPCs). Methods: We used a four-stage differentiation protocol, containing neuronal differentiation and IPC-conversion stages, and combined with pellet suspension culture to induce IPC differentiation.