At the beginning of the 21st century, medicine is increasingly
based on understanding the functions of genes and the molecular
mechanisms of diseases. In pancreatology, the understanding
of functions and dysfunctions of the exocrine and
endocrine pancreas is derived from molecular biological data
on the actions of compounds in subcellular compartments and
intracellular transcription pathways.
The tendinous chords, as functional extensions of the papillary muscles, perform the dual
function of maintaining valvular competence by preventing leaflet prolapse and
maintaining ventricular geometry by providing cross-ventricular support. The chords
originate from the apical portions of the papillary muscles or directly from the posterior
ventricular wall. They insert either into the free edge of the leaflets or on their ventricular
surface. Chords have been characterized a number of ways.