Pathobiological

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  • Hyaluronan matrices are ubiquitous in normal and pathological biological processes. This remarkable diversity is related to their unique mechanism of synthesis by hyaluronan synthases. These enzymes are normally acti-vated in the plasma membrane and utilize cytosolic substrates directly to form these large polyanionic glycosaminoglycans, which are extruded directly into the extracellular space.

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  • (BQ) Part 1 book "Cardiac resynchronization therapy" presents the following contents: Epidemiology of heart failure, pathobiology of left ventricular dyssynchrony, determinants of remodeling in systolic heart failure, summary of all large randomized trials, cardiac resynchronization therapy in special populations,...

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  • The lack of understanding of the mechanisms whereby the above aetiological factors (genetic and environmental) interact to initiate the complex pathobiology of schizophrenia is the key reason for the relative lack of progress in the development of novel drug treatments. All the antipsychotic medication that is currently in use (first and second generation) is all predicated on the so-called ‘Dopamine Hypothesis’ (discussed below) and share a common putative mechanism of action, namely dopamine antagonism.

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  • Table 40-2 Association between Pathobiology of Causative Agents and Clinical Features in Acute Infectious Diarrhea Pathobiolo gy/Agents bation Incu miting Vo Abd ominal Pain ever F rrhea Dia Period Toxin producers Preforme d toxin Bacillus cereus, Staphylococcus aureus, h 1–8 4+ 3– 1–2+ –1+ 0 4+, watery 3– Clostridi um perfringens h 8–24 Enterotox in Vibrio cholerae, enterotoxigenic Escherichia coli, Klebsiella pneumoniae, Aeromonas h 8–72 4+ 2– 1–2+ –1+ 0 4+, watery 3– species Enteroadhe rent Enteropat hogenic and d 1–8 1+ 0– 1–...

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