Hyaluronan matrices are ubiquitous in normal and pathological biological
processes. This remarkable diversity is related to their unique mechanism
of synthesis by hyaluronan synthases. These enzymes are normally acti-vated in the plasma membrane and utilize cytosolic substrates directly to
form these large polyanionic glycosaminoglycans, which are extruded
directly into the extracellular space.
(BQ) Part 1 book "Cardiac resynchronization therapy" presents the following contents: Epidemiology of heart failure, pathobiology of left ventricular dyssynchrony, determinants of remodeling in systolic heart failure, summary of all large randomized trials, cardiac resynchronization therapy in special populations,...
The lack of understanding of the mechanisms whereby the above aetiological
factors (genetic and environmental) interact to initiate the complex pathobiology of
schizophrenia is the key reason for the relative lack of progress in the development of novel
drug treatments. All the antipsychotic medication that is currently in use (first and second
generation) is all predicated on the so-called ‘Dopamine Hypothesis’ (discussed below) and
share a common putative mechanism of action, namely dopamine antagonism.
Table 40-2 Association between Pathobiology of Causative Agents and Clinical Features in Acute Infectious Diarrhea
Pathobiolo gy/Agents bation
Abd ominal Pain ever
Preforme d toxin
Bacillus cereus, Staphylococcus aureus, h
0 4+, watery
Clostridi um perfringens h
Vibrio cholerae, enterotoxigenic Escherichia coli, Klebsiella pneumoniae, Aeromonas h
0 4+, watery
Enteropat hogenic and d