Pathological implications

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  • (BQ) Part 1 book "Gastrointestinal pathology and its clinical implications" presents the following contents: Dialogue, biopsies–taking and handling, resected specimens; protocols; vascular disorders and related diseases, immunodeficiency disorders, disorders of endocrine cells, motility disorders, mesenchymal tumors,...

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  • (BQ) Part 2 book "Gastrointestinal pathology and its clinical implications" presents the following contents: Gastric epithelial polyps and tumors, small and large bowel structure - Developmental and mechanical disorders, small bowel mucosal disease, small bowel mucosal disease, enteric infections and associated diseases, small and large bowel polyps and tumors, the anal canal.

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  • This edition aims to present some relevant topics in the histopathology area that may be of interest for medical doctors and for other professionals interested in pathology. Histopathology applies basic knowledge obtained from biologic and anatomic science to make diagnosis, to determine the severity and progress of a condition and to evaluate the possible response to certain therapies. Thus, it is not surprising that this discipline constantly expands with progresses produced in biology.

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  • This book, with its 16 chapters, documents the present state of knowledge of the adenosine A3 receptor. It covers a wide range of information, including data from studies of theoretical, molecular and cellular pharmacology, signal transduction, integrative physiology, new drug discoveries and clinical applications. It fills an important gap in the literature since no alternative source of such information is currently available.

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  • First of all, we are delighted to be able to provide the "Innovative Rheumatology" to everyone involved in the treatment and research of rheumatoid arthritis. In recent years, the treatment of Rheumatoid Arthritis has undergone tremendous changes due to methotrexate and biologics in large part. Until a decade ago, avoiding joint destruction in rheumatoid arthritis was not realistic for rheumatologist. However, prevention of joint deterioration is now possible, and the quality of life of patients with rheumatoid arthritis in long-term has been able to improve by advances in treatment.

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  • In recent years, the treatment of Rheumatoid Arthritis has undergone tremendous changes due to methotrexate and biologics in large part. Until a decade ago, avoiding joint destruction in rheumatoid arthritis was not realistic for rheumatologist. However, prevention of joint deterioration is now possible, and the quality of life of patients with rheumatoid arthritis in long-term has been able to improve by advances in treatment.

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  • Cells in various anatomical locations are constantly exposed to mechanical forces from shear, tensile and compressional forces. These forces are signifi-cantly exaggerated in a number of pathological conditions arising from various etiologies e.g., hypertension, obstruction and hemodynamic over-load.

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  • a-Synuclein exists in two different compartments in vivo – correspondingly existing as two different forms: a mem-brane-bound form that is predominantlya-helical and a cytosolic form that is randomly structured. It has been sug-gested that these environmental and structural differences may play a role in aggregation propensity and development of pathological lesions observed inParkinson’s disease (PD). Such effects may be accentuated by mutations observed in familial PD kindreds.

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  • Proteins are occasionally converted from their normal soluble state to highly ordered fibrillar aggregates (amyloids), which give rise to pathologi-cal conditions that range from neurodegenerative disorders to systemic amyloidoses. Recent methodological advances in solid-state NMR and EPR spectroscopy have enabled determination of the 3D structure of sev-eral amyloids at residue-level resolution.

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  • The role of the placental bed in normal pregnancy and its complications has been intensively investigated for 50 years, following the introduction of a technique for placental bed biopsy. It is now recognized that disorders of the maternal–fetal interface in humans have been implicated in a broad range of pathological conditions, including spontaneous abortion, preterm labor, preterm premature rupture of membranes, preeclampsia, intrauterine growth restriction, abruptio placentae, and fetal death.

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  • Our understanding of the importance of noncoding RNA molecules is steadily growing. One such important class of RNA molecules are microRNAs (miRNAs). These tiny RNAs fulfi ll important functions in cellular behavior by infl uencing the protein output levels of a high variety of genes through the regulation of target messenger RNAs. Moreover, miRNAs have been implicated in a wide range of diseases. In pathological conditions, the miRNA expression levels can be altered due to changes in the transcriptional or posttranscriptional regulation of miRNA expression.

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  • The increased level of reactive oxygen species (ROS) in living organisms over 60 years ago was implicated in the development of diseases and aging (Harman, 1956; 1983). This book is a collective scientific monograph presenting several important aspects related to ROS role in human and animal pathologies. In 1985, German scientist Helmut Sies first denoted oxidative stress concept, which immediately attracted attention of researchers in diverse basic fields. Several discoveries substantially stimulated the interest to ROS as ones related to many diseases.

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  • MNB⁄DYRK1A is a member of the dual-specificity tyrosine phosphoryla-tion-regulated kinase (DYRK) family that has been strongly conserved across evolution. There are substantial data implicating MNB⁄DYRK1A in brain development and adult brain function, as well as in neurodegener-ation and Down syndrome pathologies.

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  • Matrix metalloproteinases (MMPs) consist of a multigene family of zinc-dependent extracellular matrix (ECM) remodeling endopeptidases implicated in pathological processes, such as carcinogenesis. In this regard, their activity plays a pivotal role in tumor growth and the multistep processes of invasion and metastasis, including proteolytic degradation of ECM

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  • Human glutamate carboxypeptidase II [GCPII (EC 3.4.17.21)] is recog-nized as a promising pharmacological target for the treatment and imaging of various pathologies, including neurological disorders and prostate can-cer. Recently reported crystal structures of GCPII provide structural insight into the organization of the substrate binding cavity and highlight residues implicated in substrate⁄inhibitor binding in the S1¢ site of the enzyme.

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  • Prolyl oligopeptidase (POP) is a serine protease that cleaves small peptides at the carboxyl side of an internal proline residue. Substance P, arginine– vasopressin, thyroliberin and gonadoliberin are proposed physiological substrates of this protease. POP has been implicated in a variety of brain processes, including learning, memory, and mood regulation, as well as in pathologies such as neurodegeneration, hypertension, and psychiatric disor-ders.

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  • Containing States of Mind • Wilfred Bion's insights into the analytic process have had a profound influence on how psychoanalysts and psychotherapists understand emotional change and pathological mental states. One of his most influential ideas concerns the notion that we need the minds of others to develop our own emotional and cognitive capacities. In Containing States of Mind, Duncan Cartwright explores and develops some of the implications that Bion's container model has for clinical practice.

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