Receptors for the key female reproductive hormones, estrogens, are found throughout the entire brain including prefrontal
cortex, hypothalamus, neocortex, hippocampus, amygdala, striatum, and brain stem. The neurotransmitter systems
involved in depression (serotonin, norepinephrine, dopamine, cetylcholine, GABA, glutamate) are regulated by the action
Research suggests that women may have increased susceptibility to depression and mood disorders during two key
lifecycle transitions: pregnancy and the postpartum period, and perimenopause.