Xem 1-7 trên 7 kết quả Perpetual change
  • Susan L.Lindquist*† and Steven Henikoff‡ *Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142; and ‡The Fred Hutchinson Cancer Research Center, Seattle, WA 98109 Over the past half-century, the central dogma, in which DNA makes RNA makes protein, has dominated thinking in biology, with continuing refinements in understanding of DNA inheritance, gene expression, and macromolecular interactions. However, we have also witnessed the elucidation of epigenetic phenomena that violate conventional notions of inheritance.

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  • This book contains most of the papers presented at the Eco-Architecture 2010 conference, which was the third edition of the International Conference on Harmonisation between Architecture and Nature. Previous editions were held in the New Forest, UK (2006) and the Algarve, Portugal (2008) and demonstrated the importance of a forum like this to discuss the characteristics and challenges of such architectural vision. Eco-Architecture implies a new approach to the design process intended to harmonise its products with nature.

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  • A convertible bond is a security that the holder can convert into a specified number of underlying shares. We enrich the standard model by introducing some default risk of the issuer. Once default has occured payments stop immediately. In the context of a reduced form model with infinite time horizon driven by a Brownian motion, analytical formulae for the no-arbitrage price of this American contingent claim are obtained and characterized in terms of solutions of free boundary problems.

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  • A perpetual challenge facing city governments is the quality of political leadership. Eff ective mayors provide a sense of direction and help ensure that all parts of city government are working in a coordinated and purposeful way with community support for the city’s goals. Ineff ective mayors leave their cities to drift, allow city departments and staff to work ineff ectively, and fail to make a connection with citizens. With increasingly complex problems to address, the need for leadership is even greater.

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  • Perhaps nothing is so ingrained in our senses as the perpetual pulling of the earth on our surroundings. It’s always there, never changing. It’s been hugging solids, liquids and gases to the earth’s surface for over 4 billion years. Earth’s gravity is built into our descriptions of our world with words like up, down, and weight. Exactly what is weight? A weight is a force, nothing more. Your weight is the pull of earth’s gravity on your body. Likewise, the weight of your car is the force of the earth’s attraction for it. The greater the mass is, the...

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  • The coincidence of multiple inequities in health—and as an interlinked concept, the multifaceted nature of poverty—make for a very complex field. Those living at the margins of society suffer numerous and overlapping inequities in health, in voice, in agency, in living conditions. Often, their poverty and ill health keep them in a life of perpetual quicksand. Just as an intervention might spare a child from malaria only to have her die a year later of measles, a policy change in the health sector might be successful in eliminating one source of inequity (e.g. access to care)...

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  • Designing for screen use is the opposite – even when a website or web application is pushed “live” online, it can be changed, tweaked, reconfigured and updated constantly. It is perpetual. However, the design building blocks and principles remain the same as print material, with the addition of dynamic user functionality and the user experience. The success of a website or web application is largely based upon user functionality and the user experience, and in this regard, design should be as invisible as possible.

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