Pharmaceutical applications

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  • .PHARMACEUTICAL APPLICATIONS OF RAMAN SPECTROSCOPY Edited By ˇ ˇ ´ SLOBODAN SASIC Pfizer, Ltd., Sandwich, UK WILEY-INTERSCIENCE A JOHN WILEY & SONS, INC., PUBLICATION ..PHARMACEUTICAL APPLICATIONS OF RAMAN SPECTROSCOPY ..

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  • It has been over eight years since the first edition of the Handbook of Pharmaceutical Granulation Technology was published. The enthusiastic reception afforded by the scientific community was heartwarming. The basic science of granulation has not changed much over the last few years; however, a better understanding of the theory of granulation and the proliferation of different dosage forms has.

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  • The most widely used analytical separation technique for the qualitative and quantitative determination of chemical mixtures in solution in the pharmaceutical industry is high-performance liquid chromatography (HPLC). However, conventional detectors used to monitor the separation, such as UV, refractive index, fluorescence, and radioactive detectors, provide limited information on the molecular structure of the components of the mixture. Mass spectrometry (MS) and nuclear magnetic resonance (NMR) are the primary analytical techniques that provide structural information on the analytes.

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  • Over 25 years ago, Horvath and Melander, in their fundamental work [1], discussed the reason behind the explosive popularity of reversed-phase liquid chromatography (RPLC) for analytical separations. It was estimated that about 80–90% of all analytical separations were performed in RPLC mode, and the authors noted that “the variation of eluent composition alone extends both retention and selectivity in HPLC [high-performance liquid chromatography] over an extremely broad range.

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  • Plasticizers are used to increase the process-ability, flexibility, and durability of the material, and of course to reduce the cost in many cases. This edition covers introduction and applications of various types of plasticizers including those based on non-toxic and highly effective pyrrolidones, and a new source of Collagen based bio-plasticizers that can be obtained from discarded materials from a natural source; Jumbo Squid (Dosidicus gigas).

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  • The chapter commences with a brief introduction to the technique of sugar coating, which includes a note on the advantages and disadvantages of this method of coating. The various sequential steps involved in sugar coating are covered in some detail, i.e. sealing, subcoating, smoothing, colour coating, polishing and printing. In the section dealing with subcoating several suitable formulations are provided with details regarding application. Traditionally the colour-coating step in sugar coating has received much attention as the aesthetics of this dosage form are most important.

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  • For much of the early development of liquid chromatography, separations were carried out at ambient temperature and many laboratories did not attempt to regulate or control the temperature of the column. Frequently, the column would be mounted on the side of the pump or detector and thus would be subjected to changes in the room temperature or changes due to external factors, such as sunlight. However, the influence of temperature on the retention times of analytes was well known and had been studied by a number of groups—in particular, Melander et al. [1].

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  • Recent advances in mass spectrometry have rendered it an attractive and versatile tool in industrial and academic research laboratories. As a part of this rapid growth, a considerable body of literature has been devoted to the application of mass spectrometry in clinical studies. In concert with separation techniques such as liquid chromatography, mass spectrometry allows the rapid characterization and quantitative determination of a large array of molecules in complex mixtures.

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  • Although the technologies on chiral/enantiomer separation and stereoselective analysis have matured in the past ca. 20 years, the development of new, even more advanced chiral separation materials, mechanisms and methods still belong to the more challenging tasks in separation science and analytical chemistry. An analysis of recent trends indicates that capillary electrophoresis (CE) can show real advantages over chromatographic methods in ultratrace chiral determination of biologically active ionogenic compounds in complex matrices, including mostly biological ones....

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  • This is a comprehensive source of information on the application of ion chromatography (IC) in the analysis of pharmaceutical drugs and biologicals. This book, with contributors from academia, pharma, the biotech industry, and instrument manufacturing, presents the different perspectives, experience, and expertise of the thought leaders of IC in a comprehensive manner. It explores potential IC applications in different aspects of product development and quality control testing.

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  • Today, we live almost twice longer than the generations living in the beginning of the last century. Our life expectancy has increased 35‐70 years in the last 100 years. There are several factors which are important for our longer and healthier life. One very important factor is a better understanding of the human biology. Scientists are making new breakthroughs every day. Better understanding of human biology also taught us how to improve sanitation, hygiene and fight against diseases.

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  • Medicinal chemistry is a discipline at the intersection of chemistry, especially synthetic organic chemistry, and pharmacology and various other biological specialties, where they are involved with design, chemical synthesis and development for market of pharmaceutical agents (drugs). Compounds used in medical applications are most often organic compounds, which are often divided into the broad classes of small organic molecules and biologics, the latter of which are most often medicinal preparations of proteins. Inorganic and organometallic compounds are also useful as drugs.

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  • Environmental managers, engineers, and scientists who have had experience with industrial and hazardous waste management problems have noted the need for a handbook that is comprehensive in its scope, directly applicable to daily waste management problems of specific industries, and widely acceptable by practicing environmental professionals and educators.

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  • This book presents a high level technical overview of the emerging technologies o optical communications and networking systems. It is intended as an introduction to the field for optical communication systems or network professionals, such as higher degree research students, academics and design engineers. Although it is intended for professionals who already have some technical background, it is nevertheless relevan to anyone wishing to understand optical communication systems or networks....

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  • Environmental managers, engineers, and scientists who have had experience with hazardous industrial waste problems have noted the need for a book that is comprehensive in its scope, directly applicable to daily hazardous industrial waste treatment, and widely acceptable by practicing environmental professionals and educators

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  • Environmental managers, engineers, and scientists who have had experience with process industry waste management problems have noted the need for a book that is comprehensive in its scope, directly applicable to daily waste management problems of the industry, and widely acceptable by practicing environmental professionals and educators.

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  • Scientists who dedicate their research activity to biomaterials pass through the typical dichotomy that often characterizes the basic research. On one side is the wish of exploring new frontiers of chemistry, physics, biology, medicine, pharmaceutics and all other disciplines to which biomaterials can be applied. Constantly improving of scientific knowledge would feed the freedom of attempting new strategies for producing materials with always tailored and improved characteristics.

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  • Since the invention of synthetic zeolites in 1959, innovations in sorbent development and adsorption process cycles have made adsorption a key separations tool in the chemical, petrochemical and pharmaceutical industries. In all future energy and environmental technologies, adsorption will likely play either a key or a limiting role. Some examples are hydrogen storage and CO removal (from hydrogen, to

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  • The soil ecosystem provides services such as carbon sequestration, nutrient cycling, water purification, provisioning of industrial and pharmaceutical goods, and a mitigating sink for chemical and biological agents. However, the soil is subject to various degradation processes. Its relation with the hydrosphere, biosphere, and atmosphere makes the interacting processes even more complex. Moreover, as the soilhuman interactions increase, threats, leading to a series of impacts on soil health, become more important....

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  • Human activities may seriously affect the quality of aquatic ecosystems. Pathogen organisms, nutrients, heavy metals, toxic elements, pesticides, pharmaceuticals and various other organic micropollutants enter to aquatic environment through a range of point and diffuse sources. The presence of these compounds has adverse impacts on aquatic biota. It is well recognised that the distribution and the abundance of various species in aquatic systems are directly related to the water quality and hydrological conditions....

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