The subspecialty of population pharmacokinetics was introduced into clinical pharmacology
/ pharmacy in the late 1970s as a method for analyzing observational
data collected during patient drug therapy in order to estimate patient-based pharmacokinetic
parameters. It later became the basis for dosage individualization
and rational pharmacotherapy. The population pharmacokinetics method (i.e., the
population approach) was later extended to the characterization of the relationship
between pharmacokinetics and pharmacodynamics, and into the discipline of
Since publication of the first edition of CRC Desk Reference
of Clinical Pharmacology in 1998, dramatic discoveries in
molecular medicine, along with rapid concomitant technological
advances, have revolutionized the diagnosis and
treatment of a broad range of human diseases with new
medications. Given the rapid pace of new discovery,
genetic- and cell-based therapeutics have now become a
common part of the physicians’ armamentarium. A few
examples will be given concerning two leading causes of
death—cancer and cardiovascular diseases—to illustrate this....
What is ‘biochemical pharmacology’?
• A fancy way of saying ‘pharmacology’, and of hiding
the fact that we are sneaking a subject of medical interest
into the UW biochemistry curriculum.
• An indication that we are not going to discuss prescriptions
for your grandmother’s aching knee; we will focus
on the scientific side of things but not on whether to take
the small blue pill before or after the meal.
What is it not?
• A claim that we accurately understand the mechanism
of action of each practically useful drug in biochemical