(BQ) Part 1 book "Heart rate and rhythm molecular basis pharmacological modulation and clinical implications" presents the following contents: Normal cardiac rhythm and pacemaker activity, modeling, cardiac development and anatomy, mechanisms of acquired arrhythmia.
(BQ) Part 2 book "Heart rate and rhythm molecular basis pharmacological modulation and clinical implications" presents the following contents: Mechanisms of inherited arrhythmia, role of specific channels and transporters in arrhythmia, drugs and cardiac arrhythmia.
The last decade or so has seen remarkable advances in our knowledge of cough. This
applies especially to its basic mechanisms: the types of airway sensors, the pharmacological
receptors on their membranes, the brainstem organization of the ‘cough
centre’, and the involvement of the cerebral cortex in the sensations and the voluntary
control of cough. With the exception of the last of these, nearly all the studies
have been on experimental animals rather than humans, for obvious reasons.
Drugs for the Suppression of Pain (Analgesics)
ing, or burning character, i.e., pain that can be localized only poorly. Impulse traffic in the neo- and paleospinothalamic pathways is subject to modulation by descending projections that originate from the reticular formation and terminate at second-order neurons, at their synapses with first-order neurons, or at spinal segmental interneurons (descending antinociceptive system).
The reality is more complex since the receptor binding profile of clozapine and the newer atypical antipsychotic agents suggests that D2-receptor blockade is not essential for antipsychotic effect. The atypical drugs act on numerous receptors and modulate several interacting transmitter systems. Clozapine is a highly effective antipsychotic. It has little affinity for the D2-receptor compared with classical drugs but binds more avidly to other dopamine subtypes (e.g. D1, D3 and D4). It blocks muscarinic acetylcholine receptors, as do certain classical agents (e.g.
Multiple Variants Modulating Drug Effects As this discussion makes clear, for each drug with a defined mechanism of action and disposition pathways, a set of "candidate genes," in which polymorphisms may mediate variable clinical responses, can be identified. Indeed, polymorphisms in multiple genes have been associated with variability in the effect of a single drug. CYP2C9 loss-of-function variants are associated with a requirement for lower maintenance doses of the vitamin K antagonist anticoagulant warfarin. In rarer (...
(BQ) Part 2 book "Essentials of pharmacology for anesthesia, pain medicine and critical care" presents the following contents: Histamine modulators, central nervous system stimulants, antiepileptic agents, chemotherapeutic agents, minerals and electrolytes, psychopharmacologic agents and psychiatric drug considerations,...
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Pharmacological inhibition of Akt and downstream pathways modulates the expression of COX-2 and mPGES-1 in activated microglia
The results of the BMJ Clinical Evidence review tend to indicate that as far as
antipsychotic medication goes, current drugs are of some, if limited, efficacy in many
patients, and that most drugs cause side effects in most patients. Although this is a rather
downbeat conclusion, this will not be too surprising to clinicians in the field, given their
clinical experience and our knowledge of the pharmacology of the available antipsychotic
A wide range of approaches has been applied to examine the quaternary
structure of G protein-coupled receptors, the basis of such protein–protein
interactions and how such interactions might modulate the pharmacology
and function of these receptors. These include coimmunoprecipitation, var-ious adaptations of resonance energy transfer techniques, functional com-plementation studies and the analysis of ligand-binding data.
Many pharmacologically important agents are assembled on multimodular
nonribosomal peptide synthetases (NRPSs) whose modules comprise a set
of core domains with all essential catalytic functions necessary for the
incorporation and modification of one building block. Very often, d-amino
acids are found in such products which, with few exceptions, are generated
by the action of NRPS integrated epimerization (E) domains that alter the
stereochemistry of the corresponding peptidyl carrier protein (PCP) bound