Pharmacological properties

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  • The last decade or so has seen remarkable advances in our knowledge of cough. This applies especially to its basic mechanisms: the types of airway sensors, the pharmacological receptors on their membranes, the brainstem organization of the ‘cough centre’, and the involvement of the cerebral cortex in the sensations and the voluntary control of cough. With the exception of the last of these, nearly all the studies have been on experimental animals rather than humans, for obvious reasons.

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  • Less than 20 years ago the field of cannabis and the cannabinoids was still considered a minor, somewhat quaint, area of research. A few groups were active in the field, but it was already being viewed as stagnating. The chemistry of cannabis was well known, Δ9-tetrahydrocannabinol (Δ9-THC), identified in 1964, being the only major psychoactive constituent and cannabidiol, which is not psychoactive, possibly contributing to some of the effects. These cannabinoids and several synthetic analogs had been thoroughly investigated for their pharmacological effects.

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  • The reality is more complex since the receptor binding profile of clozapine and the newer atypical antipsychotic agents suggests that D2-receptor blockade is not essential for antipsychotic effect. The atypical drugs act on numerous receptors and modulate several interacting transmitter systems. Clozapine is a highly effective antipsychotic. It has little affinity for the D2-receptor compared with classical drugs but binds more avidly to other dopamine subtypes (e.g. D1, D3 and D4). It blocks muscarinic acetylcholine receptors, as do certain classical agents (e.g.

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  • This dictionary provides a convenient personal reference source, intended to complement more encyclopaedic works. First, there is an alphabetic, fully cross-indexed listing of pharmacologically active agents and their properties, containing details of some 4000 individual chemical agents including medical drugs in current use, experimental agents and toxins used as investigation tools. Over 10,000 alternative names are indexed, including chemical names, abbreviated chemical names, official pharmacological names, proprietary names and research code numbers....

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  • (BQ) Part 2 book "Satureja - Ethnomedicine, phytochemical diversity and pharmacological activities" presents the following contents: Biological and pharmacological activity, satureja bachtiarica - Phytochemistry and pharmacology, discussion and conclusion.

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  • The health-promoting effects attributed to olive oil, and the development of the olive oil industry have intensified the quest for new information, stimulating wide areas of research. This book is a source of recently accumulated information. It covers a broad range of topics from chemistry, technology, and quality assessment, to bioavailability and function of important molecules, recovery of bioactive compounds, preparation of olive oil-based functional products, and identification of novel pharmacological targets for the prevention and treatment of certain diseases....

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  • This is a book about the most fearsome disease of modern times, which will strike every fourth citizen of a developed country sometime during his life: cancer. It is not a book about the prevention of cancer, but rather its treatment with plant-derived chemicals. It is an up-to-date and extensive review of plant genera and species with antitumor and antileukemic properties that have been documented in a strictly scientific sense.

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  • Since this book was first published in 1993, the Advanced Paediatric Life Support (APLS) concept and courses have gone a great way towards their aim of bringing simple guidelines for the management of ill and injured children to front-line doctors and nurses. Over the years an increasing number of experts have contributed to the work and we extend our thanks both to them and also to our instructors who unceasingly provide helpful feedback.The Advanced Paediatric Life Support Course is now well established in several countries outside the United Kingdom.

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  • The explosion of new technologies in the post-genomic era is allowing the study of biological systems on a genome-wide scale, at the main functional genomic levels: (epi)-genome, transcriptome, proteome, endo- and exometabolome, and their interactions. At the same time that these techniques are being applied and refined, the complexity of biological systems is being rediscovered (1) with thousands of components (e.g., genes, transcripts, proteins, metabolites) participating in finely tuned metabolic and regulatory networks.

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  • The molecular biology and mechanical properties of tendon and ligament healing and soft tissue (i.e., tendon, ligament, capsular tissues) to bone are a vital aspect of many surgical disciplines. Recent advances, both surgical and experimental, have provided great insight into new techniques, mechanisms of healing, and strategies for augmentation and repair.

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  • Basidiomycetes constitute a natural source of biologically active metabolites. Many basidiomycetes have been classified by the National Cancer Institute of the United States as antitumor agents exhibiting an immunomodulatory activity.1 The therapeutic activity is mainly related to polysaccharides or protein-bound polysaccharides, such as glucans, heterogalactans, and glucanproteins, which are present either in the mycelium or in the fruit body.2–6 Among these polysaccharides are b-D-glucans, which are of particular interest because of their pharmacological properties.

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  • The abuse of amphetamines is of national concern from a public health perspective. Review of this subject is timely and important, because the problem of amphetamine-like drugs has recently been amplified by the introduction of designer drugs in the illicit market. There has been an increasing number of attempts by chemists in clandestine laboratories to synthesize structurally altered congeners that might intensify the moodaltering property of this class of compounds.

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  • The purpose of this dictionary is to provide a convenient and affordable personal desk reference resource. The authors, who have many years experience in pharmacological research, teaching and editing, recognized a need for a single up-to-date volume encompassing material that hitherto could be gathered only from a well-stocked library. This book comprises two main sections: an A-Z listing of drugs and their properties; and a descriptive glossary of technical terms.

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  • This book has evolved from over a quarter-century of research that concentrated on delineating the aqueous coordination reactions that characterize the vanadium(V) oxidation state. At the beginning of this time period, only a minor amount of research was being done on vanadium aqueous chemistry. However, the basic tenets of 51 V NMR spectroscopy were being elaborated, and some of the influences of ligand properties and coordination geometry on the NMR spectra were being ascertained.

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  • Salvinorin A is a potent kappa opioid receptor (KOP) agonist with unique structural and pharmacological properties. This non-nitrogenous ligand lacks nearly all the structural features commonly associated with opioid ligand binding and selectivity. This study explores the structural basis to salvinorin A binding and selectivity using a combination of chimeric and single-point mutant opioid receptors.

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  • Our technique determines per-application resource quo- tas in the database and storage caches, on the fly, in a transparent manner, with minimal changes to the DBMS, and no changes to existing interfaces between compo- nents. Towards this objective, we use an online perfor- mance estimation algorithm to dynamically determine the mapping between any given resource configuration setting and the corresponding application latency.

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  • Adrenergic receptors (ARs) are expressed in almost all organs and tissues and regulate a large number of diverse physiological processes upon activation by epinephrine and norepinephrine. There are three families of ARs, a1, a2, and b-ARs, with distinct pharmacological properties and functions. Since the first identification of bARs more than three decades ago, research on ARs has led to the establishment of many fundamental concepts in G protein-coupled receptor (GPCR) pharmacology.

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  • The European Championship stadium helps the Weidmoos An important step came in 2000, when nature protection compensation measures were undertaken as a result of the construction of a new stadium in Salzburg/ Klessheim. This involved the purchase of about 80 of the 136 hectare bird reserve for nature protection purposes. In this way, the future use of the site was bound by property law. In 2002, Salzburg’s Nature Protection Department contracted REVITAL, a civil engineering consultancy firm, to develop a Natura 2000 management plan.

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  • We report the cloning, expression, pharmacological char-acterization and tissue distribution of a melanocortin (MC) receptor gene in a shark, the spiny dogfish (Squalus acanth-ias) (Sac). Phylogenetic analysis showed that this receptor is anorthologof theMC4 subtype, sharing71%overall amino acid identity with the human (Hsa) MC4 receptor. When expressedandcharacterizedbyradioligandbindingassay for the natural MSH (melanocyte-stimulating hormone) pep-tides a-, b-, and c-MSH, the SacMC4 receptor showed pharmacological properties very similar to the HsaMC4 receptor. ...

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  • Understanding the basics of pharmacology is an essential nursing responsibility. Pharmacology is the science that deals with the physical and chemical properties, and biochemical and physiologic effects, of drugs. It includes the areas of pharmacokinetics, pharmacodynamics, pharmacotherapeutics, pharmacognosy, and toxicodynamics.

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