Three distinct sequential cellular responses characterise the reaction of the adult
spinal cord and brain to injury. An acute
after wounding, in which haematogenous cells flood the lesion site. This is followed
during which macrophages clear necrotic debris, glial cell
reactions are mobilised, the clot becomes organised, and scarring is initiated. Finally,
the scar tissue contracts during a
Cet ouvrage présente les travaux du groupe de travail réuni par l’Inserm et
l’Institut de veille sanitaire (InVS) dans le cadre de la procédure d’expertise
opérationnelle pour répondre à la demande de la Direction générale de la santé
concernant les stratégies de dépistage du saturnisme chez l’enfant. Il constitue
un prolongement et un complément de l’expertise collective publiée en 1999
intitulée « Plomb dans l’environnement : quels risques pour la santé ? ».
Emergency Vascular Surgery – A Practical Guide provides a concise guide to
managing patients with all kinds of emergent vascular problems. It is not intended
to be a “classic” textbook, so the background information given is very
concise. The focus is instead on management and treatment, especially open
The text is written for newcomers to the vascular surgical field, for surgical
trainees, and for all doctors who treat emergent vascular surgical patients in
the emergency department....
Times have changed and so should our intellectual basis for the management of diseases and
conditions. Once thought of as an anatomic structure containing disparate and unrelated viscera,
the human pelvis is now appreciated as a functional syncytium as complex as any within the
human body. The dysfunctions of urinary, genital, and gastrointestinal elements which
constitute this complex functional–anatomic arrangement require comprehensive and inclusive
Despite the significant decline in heart disease mortaht' rates over the last 25 years, heart
failure has remained a significant problem. We are now confronted with large numbers of
terminally ill patients for whom conventional therapies for heart failure have been exhausted
and for whom repeated hospital visits are necessary.
There now is a major thrust towards a management strategy which embraces a
comprehensive approach including vigorous preventive measures and earlier surgical
Increasing numbers of children are recognised as experiencing an autistic
spectrum disorder, and educational provision for most of these children is found
within a mainstream school. Autistic spectrum disorders (ASDs) are also
sometimes referred to as pervasive development disorders because they pervade
so many areas of life and are intrinsic to that individual’s development.
Since this book was first published in 1993, the Advanced Paediatric Life Support
(APLS) concept and courses have gone a great way towards their aim of bringing simple
guidelines for the management of ill and injured children to front-line doctors and
Over the years an increasing number of experts have contributed to the work and we
extend our thanks both to them and also to our instructors who unceasingly provide
helpful feedback.The Advanced Paediatric Life Support Course is now well established
in several countries outside the United Kingdom.
In this chapter I will review the current status of treatment for schizophrenia in terms of
effectiveness and safety, and discuss what treatment advances have been made in the last
century, and how treatment interventions might and should develop as the 21st century
Our goal in this book is to provide the reader with only the most crucial
and important points for the variety of disorders likely to be encountered
in the adult intensive care unit, including the key first steps
in diagnosis, confirmation of diagnosis, and initial management strategies.
In preparing the manuscript, we were struck by several insights.
First was the importance of general supportive care of the patient regardless
of the primary diagnosis leading to admission to the ICU.
The molecular biology and mechanical properties of tendon and ligament healing
and soft tissue (i.e., tendon, ligament, capsular tissues) to bone are a vital aspect of
many surgical disciplines. Recent advances, both surgical and experimental, have provided
great insight into new techniques, mechanisms of healing, and strategies for augmentation
Healthcare in the UK has experienced intense
change over the past few years, much of which
has been focused on the perioperative environment.
The NHS Plan, introduced by the Labour
government in 2000, was at the forefront of the
modernisation of the UK’s National Health Service.
Focusing on major areas of concern, such as
modernisation of the workforce, increasing patient
choice, and increasing the efficiency and effectiveness
of patient care, the government strategy to
rebuild the NHS has affected every segment of the
This volume is based on the proceedings of the first annual Peacocks polycystic ovary
syndrome (PCOS) Forum on Disease Mechanisms and Therapeutic Strategies, October
6–9, 2005, Chateau de Vault de Lugny, Avallon, France. The Peacocks was founded
by R. Jeffrey Chang, Andrea Dunaif, Stephen Franks, Richard S. Legro, and Samuel
S. C. Yen. The name is based on PCOS when it is pronounced as a word “pcos” rather
than as individual letters. The purpose of the Peacocks is to organize biannual meetings
of experts to review the latest developments in the field.
Equally bewildering to the student are the proper use of diagnostic tests and the integration of the results into the clinical assessment. The novice medical practitioner typically uses a "shotgun" approach to testing, hoping to hit a target without knowing exactly what that target is. The expert, on the other hand, usually has a specific target in mind and efficiently adjusts the testing strategy to it. The second goal of this chapter is to review briefly some of the crucial basic statistical concepts that govern the proper interpretation and use of diagnostic tests.
The origins of tissue engineering date to the sixteenth century when complex skin flaps were used to replace the nose. Modern tissue engineering combines the disciplines of materials sciences and life sciences to replace a diseased or damaged organ with a living, functional substitute. The most common tissue engineering approach combines cells and matrices to produce a living structure (Fig. 69-1). These strategies also include the use of scaffolding, cells, and growth factors to shape new tissues.
Urinary incontinence and pelvic prolapse have
affected the quality of many lives over the years.
Only recently, however, has increased attention
to these areas led to a better understanding of
the epidemiology, pathophysiology, and newer
approaches to treatment, both from the pharmacological
and device standpoint. This text is a
step forward in bringing these new innovations
together in a comprehensive and well-organized
The Thematic Strategy was published in late 2005 and constitutes an important step
in a series of initiatives that have contributed to the development of Europe’s policy
on the urban environment. Given the diversity of urban areas and existing national,
regional and local circumstances the Strategy does not dictate the solutions that
cities should adopt as it would be impossible to propose a "one size fits all"
With publication of the human genome has come an
experiment in reductionism for drug discovery. With the
evaluation of the number and quality of new drug
treatments from this approach has come a reevaluation
of target-based versus systems-based strategies. Pharmacology,
historically rooted in systems-based approaches
and designed to give systems-independent measures
of drug activity, is suitably poised to be a major (if
not the major) tool in this new environment of drug
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Recent developments and strategies in pediatric pharmacology research in the USA...
We briefly introduce the most common lysosomal storage disorder, Gau-cher disease, concisely describe the Food and Drug Administration
approved strategies to ameliorate Gaucher disease, and then outline the
emerging pharmacologic chaperone strategy that offers the promise to
remedy this malady.
PARKSERVICE is a new telemedical application combining home-based support for
people with Parkinson’s disease (PD) and a PD-specific walking aid which uses a
strategy known as visual cueing. PD is estimated to affect 100-180 per 100,000 of the
population (with most surveys favoring the higher estimate) and has an annual
incidence of 4-20 per 100,000,. Taking a population of approximately 450M
citizens this implies 450,000-900,000 people with PD (PWP) in the EU.