Xem 1-20 trên 93 kết quả Pluripotent stem cells
  • Nuclear Reprogramming Development naturally progresses from totipotent fertilized eggs to pluripotent epiblast cells, to multipotent cells, and finally to terminally differentiated cells. According to Waddington's epigenetic landscape, this is analogous to a ball moving down a slope. The reversal of the terminally differentiated cells to totipotent or pluripotent cells (called nuclear reprogramming) can thus be seen as an uphill gradient that never occurs in normal conditions.

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Epigenomics of human embryonic stem cells and induced pluripotent stem cells: insights into pluripotency and implications for disease

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Capturing Alzheimer’s disease genomes with induced pluripotent stem cells: prospects and challenges

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Transcriptomic analysis of pluripotent stem cells: insights into health and disease

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Induced pluripotent stem cells free of exogenous reprogramming factors...

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  • For cell-based bone tissue engineering, various tissues derived cells are utilized since osteogenic cells can be harvested from bone marrow, periosteum, and adipose tissue, though recent studies indicate that bone marrow stromal cells (BMSCs, bone marrow derived multipotent mesenchymal stromal cells, or mesenchymal stem cells) are the most reliable cell source because of their superior osteogenic ability (Hayashi et al., 2008). However, it is difficult to obtain adequate numbers of transplantable BMSCs from bone marrow aspirates, as they are rare in the bone marrow (less than 0.

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  • Human embryonic stem cell (hESC) lines, like those from other species, are pluripotent cell lines derived from the inner cell mass (ICM) of the developing embryo. Due to their exceptional capability of proliferating indefi nitely as undifferentiated cells when cultured in appropriate conditions, and of sustaining a normal karyotype, hESCs may have broad applications for industrial uses; clinical purposes, namely, cell-based therapy; and research of early human development, differentiation mechanisms, and lineage commitment.

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  • The editor has incorporated scientific contributions from a diverse group of leading researchers in the field of hematology and related blood cell research. This book aims to provide an overview of current knowledge pertaining to our understanding of hematology. The main subject areas will include blood cell morphology and function, the pathophysiology and genetics of hematological disorders and malignancies, blood testing and typing, and the processes governing hematopoiesis. Blood cell physiology, biochemistry and blood flow are covered in this book....

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  • The prediction of transcription factor binding sites in genomic sequences is in principle very useful to identify upstream regulatory factors. However, when applying this concept to genomes of multi- cellular organisms such as mammals, one has to deal with a large number of false positive predic- tions since many transcription factor genes are only expressed in specific tissues or cell types.

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  • Hydroxyurea’s efficacy in sickle cell disease is generally attributed to its ability to raise the levels of Hb F in the blood; however, the mechanisms by which it does so are unclear. Early studies suggested that hydroxyurea is cytotoxic to the more rapidly dividing late erythroid precursors, resulting in the recruitment of early erythroid precursors with an increased capacity to produce Hb F.

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  • While prominence in health policy greatly affects the size of the PHI market – in terms of population coverage, contribution to health financing or scope of government interventions – there is no necessary link between the three factors. There are sizeable PHI markets in a range of health systems with diverse mixes of public and private financing. The size of PHI markets may also result from consumer demand for better choice and more comprehensive cover, even where there is little stimulation through policy levers.

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  • A distinction is to be made between the terms 'efficacy' and 'effectiveness'. Efficacy is defined as "the probability of benefit to individuals in a defined population from a medical technology applied for a given medical problem under ideal conditions of use". By contrast, effectiveness is considered to have all the attributes of efficacy but to reflect "performance under ordinary conditions by the average practitioner for the typical patient" [12].

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  • The population of disabled elderly in the United States is growing rapidly. The number of Americans who will suffer functional disability due to arthritis, stroke, diabetes, coronary artery disease, cancer, or cognitive impairment is expected to increase at least 300 percent by 2049.1 Although people tend to develop chronic conditions as they age, growing old does not have to mean becoming disabled.

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  • But how far should the public sector go in defining the terms of maturity transformation?. It would be reassuring to imagine that underlying saving and investment propensities of the private sector define the real interest rate in normal times. Keynes threw some doubt on this classical view. In addition, the fact is that government policies nowadays dominate the terms of maturity transformation in modern economies. Very large government debt defines the yield curve.

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  • Clean air is a basic requirement of life. The quality of air inside homes, offices, schools, day care centres, public buildings, health care facilities or other private and public buildings where people spend a large part of their life is an essential determinant of healthy life and people’s well-being. Hazardous substances emit- ted from buildings, construction materials and indoor equipment or due to hu- man activities indoors, such as combustion of fuels for cooking or heating, lead to a broad range of health problems and may even be fatal....

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  • In recent years, the food and beverage industry in the US has viewed children and adolescents as a major market force. As a result, children and adolescents are now the target of intense and specialized food marketing and advertising efforts. Food marketers are interested in youth as consumers because of their spending power, their purchasing influence, and as future adult consumers. Multiple techniques and channels are used to reach youth, beginning when they are toddlers, to foster brand-building and influence food product purchase behavior.

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  • The current report summarises the outcomes of all of the tasks, and gives an outline of the methodology used. This report is divided into six chapters. Chapter 2 describes the methodological approach of the FORVALUE Study, and chapters 3 to 6 present the main results of the study. Chapter 3 is dedicated to the identification, characterization and classification of forest goods and services. It also identifies and briefly describes the main user groups, forest owners and access to forest goods and services.

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  • Before we describe the current books, let us first briefly compare them to the previous book in retrospective. First of all, there were some very promising directions a decade ago that unfortunately did not meet the expectations. Molecular biology and genetics, particularly in regards to expression of stress proteins and other pathways related to the cell injury, have not introduced any serious breakthroughs except for the use of ROCK inhibitors for cryopreservation of human embryonic and induced pluripotent stem cells.

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  • Global warming and changes in climate have already had observed impacts on natural ecosystems and species. Natural systems such as wetlands, mangroves, coral reefs, cloud forests, Arctic and high latitude ecosystems are especially vulnerable to climate‐induced disturbances. Enhanced protection and management of biological resources and habitats can mitigate impacts and contribute to solutions as nations and communities strive to adapt to climate change. Biodiversity is the foundation and mainstay of agriculture, forests, and fisheries.

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  • We would like to know whether you feel there are areas that we should review, and whether you think a statutory insurance code is desirable. In Part 4 of this paper we have asked you to list those areas you think we should review, and to rank them in order of importance. Your responses will be considered by the Commissioners before they determine the scope of this project in the light of the resources available to us.

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