Xem 1-6 trên 6 kết quả Post-translational
  • Phát triển là quá trình kiểm soát sự biểu hiện gen, quá trình điều hòa phức tạp về cơ chế, cơ bản có 5 mức độ: 1- Sự xoắn của NST (Chromatin Packing) 2- Kiểm soát sự phiên mã (Transcriptional Control) 3- Điều hòa hậu phiên mã (Posttranscriptional) [Nhân tế bào (Nuclear levels)] 4- Kiểm soát sự giải mã (Translational Control) 5- Điều hòa hậu giải mã (Posttranslational Control) [Cytosol (Cytoplasmic levels)] Sự điều hòa phiên mã bởi những phân tử protein,yếu tố phiên mã (transcription fact...

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  • Protein phosphorylation is a reversible posttranslational modification catalyzed by protein kinases and reversely by protein phosphatases. There are about 500 protein kinases and 25-30 phosphatases in human genome. Each kinase and phosphatase targets multiple substrates. Thus, protein phosphorylation is a most versatile signaling regulatory mechanism and constitutes a most complicated signaling network in living organisms. In fact, protein phosphorylation governs all aspects of physiological and pathological processes in human health....

    pdf476p taurus23 27-09-2012 28 5   Download

  • Flow of genetic information. Multiple extracellular signals activate intracellular signal cascades that result in altered regulation of gene expression through the interaction of transcription factors with regulatory regions of genes. RNA polymerase transcribes DNA into RNA that is processed to mRNA by excision of intronic sequences. The mRNA is translated into a polypeptide chain to form the mature protein after undergoing posttranslational processing.

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  • Transcriptional activation can be divided into three main mechanisms: 1. Events that alter chromatin structure can enhance the access of transcription factors to DNA. For example, histone acetylation generally opens chromatin structure and is correlated with transcriptional activation. 2. Posttranslational modifications of transcription factors, such as phosphorylation, can induce the assembly of active transcription complexes.

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  • Susan L.Lindquist*† and Steven Henikoff‡ *Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142; and ‡The Fred Hutchinson Cancer Research Center, Seattle, WA 98109 Over the past half-century, the central dogma, in which DNA makes RNA makes protein, has dominated thinking in biology, with continuing refinements in understanding of DNA inheritance, gene expression, and macromolecular interactions. However, we have also witnessed the elucidation of epigenetic phenomena that violate conventional notions of inheritance.

    pdf141p banhkem0908 24-11-2012 27 2   Download

  • Functional diversity of potassium channels in both prokaryotic and euk-aryotic cells suggests multiple levels of regulation. Posttranslational regula-tion includes differential subunit assembly of homologous pore-forming subunits. In addition, a variety of modulatory subunits may interact with the pore complex either statically or dynamically. Kv2.1 is a delayed recti-fier potassium channel isolated by expression cloning.

    pdf13p fptmusic 11-04-2013 11 1   Download

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