Xem 1-20 trên 207 kết quả Potential biological
  • Biological Risk Engineering — Infection Control and Decontamination provides a compendium of biological risk management information. Biological risk is of concern to us all. The biological risks we face vary and include biological contamination within our environment and, more personally, biological risk to ourselves through disease or the potential for disease. This book deals with a subset of biological risk agents defined as bacteria, molds, yeasts, viruses, and prions. The term biologicals refers to these agents.

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  • Harrison's Internal Medicine Chapter 66. Stem Cell Biology Stem Cell Biology: Introduction Stem cell biology is a relatively new field that explores the characteristics and possible clinical applications of the different types of pluripotential cells that serve as the progenitors of more differentiated cell types. In addition to potential therapeutic applications (Chap. 67), patient-derived stem cells can also provide disease models and a means to test drug effectiveness.

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  • After the first edition published in 2007 that became a best seller, the continuous scientific developments in the field have prompted us to produce the second edition of this book. As it happens in life and science, some of the novel and promising data presented in the first edition have been confirmed, some not, and new breakthrough achievements have been accomplished. Stem Cells in Reproductive Medicine, Basic Science and Therapeutic Potential, second edition, updates the revolutionary advances in stem cell science that may potentially impact on human reproductive medicine.

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  • Diabetes Mellitus The success of islet cell and pancreas transplantation provides proof of concept for a cell-based approach for type I diabetes. However, the demand for donor pancreata far exceeds the number available, and maintenance of long-term graft survival remains a problem. The search for a renewable source of stem cells capable of regenerating pancreatic islets has therefore been intensive. Pancreatic βcell turnover occurs in the normal pancreas, although the source of the new βcells is controversial.

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  • Other Organ Systems and the Future The use of stem cells in regenerative medicine has been studied for many other organ systems and cell types, including skin, eye, cartilage, bone, kidney, lung, endometrium, vascular endothelium, smooth muscle, striated muscle, and others. In fact, the potential for stem cell regeneration of damaged organs and tissues is virtually limitless. However, numerous obstacles must be overcome before stem cell therapies can become a widespread clinical reality.

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  • The forty-fifth volume of this series contains eight reviews written by an international array of authors; as usual, the reviews range widely in subject and taxonomic and geographic coverage. The editors welcome suggestions from potential authors for topics they consider could form the basis of future appropriate contributions. Because an annual publication schedule necessarily places constraints on the timetable for submission, evaluation and acceptance of manuscripts, potential contributors are advised to make contact with the editors at an early stage of preparation.

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  • For the analysis of biological samples two blood samples were taken, one with 5 ml heparin for the determination of acetyl cholinesterase (AChE) and pseudo cholinesterase (PChE) by the technique of Michel and Aldrige (Vorhaus and Kark, 1953) and another of 5 ml without anticoagulant for the analysis of OC pesticides in serum.

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  • The emerging field of nanotechnology is affirming its increasing importance day by day. In this context fullerenes and carbon nanotubes (CNTs) play an important role. These new allotropic forms of carbon have been discovered in the last two decades, and, since then, they have stimulated the curiosity and interest of physicists and chemists. This book is the first of a new series entitled “Carbon Materials: Chemistry and Physics”, the purpose of which is to analyze the new frontiers of carbon.

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  • The 42nd volume of this series contains eight reviews written by an international array of authors that, as usual, range widely in subject and taxonomic and geographic coverage. The majority of articles were solicited, but the editors always welcome suggestions from potential authors for topics they consider could form the basis of appropriate contributions.

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  • Forensic DNA Typing charts the progress and development of DNA applied to criminal forensics, providing vivid demonstrations of the amazing potential of the method, not only to convict the guilty but also to exonerate the innocent. John Butler has created a text that caters to all audiences, covering the basics of DNA structure and function and describing in detail how the techniques are used. In addition, the extensive use of D.N.A. (Data, Notes, and Application) Boxes in the text enables the reader to dip in and out as he or she pleases....

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  • Plants defend themselves from other organisms by elaborating bioactive chemical defences. This is the essential basis of the use of herbal medicines that still represents a major therapeutic resort for much of humanity However, at the outset, it must be stated that any plant that is not part of our evolved dietary cultures is potentially dangerous. Commercial herbal medicinal preparations approved by expert regulatory authorities have a significant place in mainstream conventional medicine and in complementary medicine.

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  • Figure 80-6 Oncogene signaling pathways are activated during tumor progression and promote metastatic potential. This figure shows a cancer cell that has undergone epithelial to mesenchymal transition (EMT) under the influence of several environmental signals. Critical components include activated transforming growth factor beta (TGF-β) and the hepatocyte growth factor (HGF)/c-Met pathways, as well as changes in the expression of adhesion molecules that mediate cell-cell and cellextracellular matrix interactions.

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  • Cushing's Syndrome Although obese patients commonly have central obesity, hypertension, and glucose intolerance, they lack other specific stigmata of Cushing's syndrome (Chap. 336). Nonetheless, a potential diagnosis of Cushing's syndrome is often entertained. Cortisol production and urinary metabolites (17OH steroids) may be increased in simple obesity.

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  • Several general principles have arisen from these studies. Bevacizumab appears to potentiate the effects of many different types of active chemotherapeutic regimens used to treat a variety of different tumor types. No phase III trials have demonstrated single-agent activity for bevacizumab; colon and lung cancer trials have demonstrated a lack of activity when used alone. An exception may be renal cell cancer (RCC), a tumor that is specifically dependent upon VEGF as the result of deletion of the VHL tumor suppressor and activation of the HIF-1α transcription factor (see above).

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  • Alternatives to Transfusion Alternatives to allogeneic blood transfusions that avoid homologous donor exposures with attendant immunologic and infectious risks remain attractive. Autologous blood is the best option when transfusion is anticipated. However, the cost:benefit ratio of autologous transfusion remains high. No transfusion is a zerorisk event; clerical errors and bacterial contamination remain potential complications even with autologous transfusions.

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  • The increasing number of chromosomal rearrangements involving the humanMLLgene, in combination with differences in clinical behavior and outcome for MLL-rearranged leukemia patients, makes it necessary to reflect on the cancer mechanism and to discuss potential therapeutic strate-gies. To date, 64 different translocations have been identified at the molecular level.

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  • Cyclosporin A induces closure of the mitochondrial permeability transition pore. We aimed to investigate whether this closure results in concomitant increases in mitochondrial membrane potential (DWm) and the produc-tion of reactive oxygen species.

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  • This chapter describe how proton pumps function in transport of materials across membranes; define the following terms: osmosis, water potential, flaccid, turgor pressure, turgid; explain how aquaporins affect the rate of water transport across membranes; describe three routes available for short-distance transport in plants;...

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  • Collection of reports on medical research published in the medical journal Critical Care helps you have more knowledge about medicine subjects: Should digestion assays be used to estimate persistence of potential allergens in tests for safety of novel food proteins?

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  • Although highly conserved throughout evolution, the exact biological function of the prion protein is still unclear. In an effort to identify the potential biological functions of the prion protein we conducted a small-molecule screening assay using the Syrian hamster prion protein [shPrP(90– 232)].

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