Xem 1-20 trên 126 kết quả Potential therapy
  • The increasing number of chromosomal rearrangements involving the humanMLLgene, in combination with differences in clinical behavior and outcome for MLL-rearranged leukemia patients, makes it necessary to reflect on the cancer mechanism and to discuss potential therapeutic strate-gies. To date, 64 different translocations have been identified at the molecular level.

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  • Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Silencing the epidermal growth factor receptor gene with RNAi may be developed as a potential therapy for non small cell lung cancer

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  • In the last 10 years gene therapy has experienced a renascence thanks to the development of safer and more efficient gene transfer vectors and to the advances in the cell therapy field. This book brings together a comprehensive collection of gene therapy tools and their thera‐ peutic applications. The first part of the book covers different gene therapy vectors focusing on their advantages and disadvantages.

    pdf754p lyly_5 22-03-2013 42 6   Download

  • There is no doubt that the introduction and evolution of regenerative and implant therapies affords clinicians the opportunity to provide patients with previously undreamt-of treatment outcomes. However, such therapeutic approaches must not be visualized as an end to themselves. The goals of conscientious and comprehensive therapy remain the maximization of patient comfort, function, and esthetics in both the short and long terms.

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  • Alternatives to Transfusion Alternatives to allogeneic blood transfusions that avoid homologous donor exposures with attendant immunologic and infectious risks remain attractive. Autologous blood is the best option when transfusion is anticipated. However, the cost:benefit ratio of autologous transfusion remains high. No transfusion is a zerorisk event; clerical errors and bacterial contamination remain potential complications even with autologous transfusions.

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  • ‘Engineering Toxins for 21st Century Therapies’ (9–10 September 2010) was part of the Royal Society International Seminar series held at the Kavli International Centre, UK. Participants were assembled from a range of disciplines (academic, industry, regulatory, public health) to discuss the future potential of toxin-based therapies.

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  • Most of the concern about mercury focuses on lakes and other aquatic ecosystems, such as rivers, streams, wetlands and oceans. The levels of mercury found in terrestrial environments are usually not high enough to threaten the health of wildlife and humans. But some aquatic environments favour the transformation of mercury into its more poisonous form — methylmercury — and it is the bioac- cumulation of methylmercury in fish and marine mammals that presents a potential problem when they are consumed by humans.

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  • Currently, adult cells seem to have certain advantages regarding rapid clinical translation. Most biomaterials used in Tissue Engineering are based on acellular matrices or polyglycolic acid. Both materials must provide tissue support until the cells produce their own extracellular matrix. Ideally, they degrade thereafter without any toxic byproducts. Over the last years we started to understand the influence of the biomechanical environment allowing these cell-biomaterial composites to unfold their full functional potential.

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  • As with the first and second editions, the goal of this third edition of Pediatric Epilepsy: Diagnosis and Therapy is to assist all professionals involved in the care of pediatric patients with seizures and epilepsy. Our goal continues to be the perfect result: no seizures, no side effects, and no stigma to limit these children from achieving their full potential.

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  • With contributions from many of the world's leading scientists in the field of dendritic research and development, Dendrimers and Other Dendritic Polymers provides a comprehensive review of this rapidly expanding and exciting new field of polymer science. Of interest to academia and industry alike, this book covers the synthesis, characterization, unique properties, potential for novel applications and technical challenges associated with these polymers.

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  • Thus, to date, women have not featured prominently as business leaders within the veterinary profession, nor have they been perceived as potential entrepreneurs or innovators. This point is particularly important, because based on what we know about women and business ownership/entrepreneurship generally (see, for example, Brush, 1997; Brush, Carter, Gatewood, Green & Hart, 2001; Henry & Treanor, 2010), it is unlikely that current levels of veterinary entrepreneurship will be maintained or, indeed, increased in a female dominated veterinary sector. ...

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  • In the time it takes you to make just one in-person sales call, you could stay at your office, pick up the telephone, and potentially reach dozens, if not hundreds, of potential prospects, using basic outbound telemarketing efforts.

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  • Tissue Engineering is the first medical therapy where engineered tissues could potentially become fully integrated within the patient, thus offering a permanent cure for many diseases not curable today.

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  • Presence of epigenetic marks enables cells with the same genotype have potential to display different phenotypes and differentiate into many cell-types with different functions, and responses to environmental and intercellular signaling. For example, DNA methylation is essential for the process of imprinting. Imprinted genes are expressed from only one parental allele. This mono-allelic gene expression is directed by epigenetic marks established in the mammalian germ line and a single mutation, either genetic or epigenetic, can cause disease.

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  • Automatic sampler (optional)—The sampler must incorporate glass sample containers for the collection of a minimum of 250 mL of sample. Sample containers must be kept refrigerated at 4°C and protected from light during compositing. If the sampler uses a peristaltic pump, a minimum length of compressible silicone rubber tubing may be used. Before use, however, the compressible tubing should be thoroughly rinsed with methanol, followed by repeated rinsings with distilled water to minimize the potential for contamination of the sample.

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  • The emerging field of nanotechnology is affirming its increasing importance day by day. In this context fullerenes and carbon nanotubes (CNTs) play an important role. These new allotropic forms of carbon have been discovered in the last two decades, and, since then, they have stimulated the curiosity and interest of physicists and chemists. This book is the first of a new series entitled “Carbon Materials: Chemistry and Physics”, the purpose of which is to analyze the new frontiers of carbon.

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  • Common to these episodes is a struggle to manage tensions associated with the (long- term) movement of accountants into markets that have not been conventionally associated with their professional expertise and status.

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  • A clustering of the disease among close relatives has also been shown, although there is no consensus on which inheritable genetic defects are involved. In spite of extensive research, reliable findings on risk factors relating to lifestyle, diet or the environment remain elusive. Possible lifestyle risk factors are high intakes of α-linolenic acid (a polyunsaturated fatty acid in vegetables and dairy products) and calcium.

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  • Others are more avowedly ‘political’ or polemical in intent. The ‘artistic’ and the ‘political’ are far from separate categories, however. Formal experiment and departure from dominant conventions is, potentially, a major resource for the deconstruction of dominant ideologies.

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Microcirculatory alterations: potential mechanisms and implications for therapy

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