Xem 1-20 trên 56 kết quả Potential toxicities
  • This book "New Insights into Toxicity and Drug Testing" covers all emerging technologies (profiling technologies, 3D cultures, next generation sequencing etc.), available methods and models to evaluate candidate drugs and medicinal plants with reference to toxicity, drug testing and development. This book is an original contribution of experts from different parts of the globe and the in-depth information will be a significant resource for scientists and physicians who are directly dealing with drugs / medicines and human life....

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  • Tham khảo sách 'committee on toxicity of chemicals in food, consumer products and the environment - subgroup report on the lowermoor water pollution incident', khoa học tự nhiên, công nghệ môi trường phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả

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  • Within the overall transport process, attenuation processes may cause movement of the chemical to differ from that of the bulk flowing groundwater, for example dispersion, sorption and chemical or biological degradation of the chemical. Such attenuation processes potentially act to mitigate the impact of chemicals and are a function of both the specific chemical and geologic domain. Indeed, attenuation may vary significantly between individual chemicals and within different geological settings.

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  • At the open burning sites, some metals were present at concentrations over one hundred times typical background levels for soils, including lead, a highly toxic metal. High levels of other toxic metals, including cadmium and antimony, were also present. Numerous classes of organic chemicals were also present in one or more of the samples, including many halogenated (chlorinated or brominated) chemicals. Many of the compounds identified are intentionally used in electronic devices.

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  • Porous metal organic framework nanoscale carriers as a potential platform for drug delivery and imaging, In the domain of health, one important challenge is the efficient delivery of drugs in the body using non-toxic nanocarriers. Most of the existing carrier materials show poor drug loading and or rapid release of the proportion of the drug that is simply adsorbed at the external surface of the nanocarrier.

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  • Currently, adult cells seem to have certain advantages regarding rapid clinical translation. Most biomaterials used in Tissue Engineering are based on acellular matrices or polyglycolic acid. Both materials must provide tissue support until the cells produce their own extracellular matrix. Ideally, they degrade thereafter without any toxic byproducts. Over the last years we started to understand the influence of the biomechanical environment allowing these cell-biomaterial composites to unfold their full functional potential.

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  • The contamination of metals is a major environmental problem and especially in the aquatic environment. Some metals are potentially toxic or carcinogenic even at very low concentration and are thus, hazardous to human if they enter the food chain. Metals are usually dissolved into the aquatic system through natural or anthropogenic sources. Metal ions are distributed thoroughly during their transport in different compartments of the aquatic ecosystems, in biotic or abiotic compartment such as fishes, water, sediment, plant.

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  • The balance sheets of life and non-life insurance companies reflect the importance of technical (insurance underwriting) risks for insurance firms. Life insurance companies typically have the greater part of their liabilities taken up by technical provisions, in some jurisdictions more than 80 percent. This reflects the amount that the firm is setting aside to pay potential claims on the policies that it has written. Correspondingly, more than 90 percent of the assets of life insurance companies comprise the investment portfolio held to support these liabilities.

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  • Clostridium perfringense-toxin is produced by toxinotypes B and D strains. The toxin is the aetiological agent of dysentery in newborn lambs but is also associated with enteritis and enterotoxaemia in goats, calves and foals. It is considered to be a potential biowarfare or bioterrorism agent by the US Government Centers for Disease Control and Prevention.

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  • However, cellular uptake of aglycones has been suggested to occur in their native form by passive diffusion. Absorbed polyphenols can directly undergo phase II metabolism as phenolic structures are generally unfavorable substrates to the cytochrome P450s (phase I metabolism). At nutritional doses, almost all polyphenols are conjugated to form O- glucuronides, sulfate esters and O-methyl ethers, by glucuronidation, sulfation and methylation, in the gut mucosa and later in the liver or kidney.

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  • building raised beds. Raised beds have soil a few inches or more higher than the surrounding area, which provides extra rooting depth, and helps the soil drain and warm up in the spring. They’re typically 3 to 4 feet wide, with mulched paths in between, so you walk on the paths and don’t compact the soil in planting areas. Raised bed sides can be made with reused lumber, broken concrete or concrete blocks, recycled plastic lum- ber, or any non-toxic material. (Don’t use treated wood.) You can also make raised beds without sides. Dig a few inches of soil out of...

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  • Hypothermia: Treatment When a patient is hypothermic, target organs and the cardiovascular system respond minimally to most medications. Moreover, cumulative doses can cause toxicity during rewarming because of increased binding of drugs to proteins, and impaired metabolism and excretion. As an example, the administration of repeated doses of digoxin or insulin would be ineffective while the patient is hypothermic, and the residual drugs are potentially toxic during rewarming. Achieving a mean arterial pressure of at least 60 mmHg should be an early objective.

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  • Chemicals are able to bring about both desirable and undesirable effects on organisms to which they are exposed, and the actions of medicines and poisons and toxic agents have been recognized for thousands of years. As a result of industrialization, modern man and the environment is now exposed to increasing numbers of chemicals. Because of their potential hazard, there is an appreciation of the requirement to assess the effects of these chemicals. Since chemical structure was elucidated (for a very brief history see Table 1.

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  • Epidemiological studies conducted during the past decade revealed that CD is one of the most common lifelong disorders worldwide. CD can manifest with a previously unsuspected range of clinical presentations, including the typical malabsorption syndrome and a spectrum of symptoms potentially affecting any organ system. Since CD is often atypical or even silent on clinical ground, many cases remain undiagnosed and exposed to the risk of long term complications, such as anemia and other hematological complications, osteoporosis, neurological complications or cancer....

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  • It is likely that with climate change (which could lead to increased rainfall, river flows, and higher coastal storm surges) and development pressures, flood risk in England is going to increase in the future, with potentially the most significant changes likely to happen in the latter half of the century. The Environment Agency has prepared a Long-term investment strategy that will allow us to understand future levels of risk and what investment may be needed to manage it over the next 25 years and beyond.

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  • Your lender is be a valuable part of your investment team. Home mortgage consultants should be trained to interview you in a way that gets them a clear understanding of your goals, so they can make recommendations that help you further your wealth-building potential. Working together, they can help you explore your options and tailor solutions to meet your individual investment criteria. You can fund your investment in a number of ways, so it’s important to understand all your options and select the one that best suits your budget needs and financial goals.

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  • The learning environment we present consists of several components (modules) that are well-known Web 2.0 applications such as wikis, weblogs, social bookmarking services and RSS feeds. The section describing the implementation of the environment in a use case at the Darmstadt University of Applied Science focuses on the specific didactic contribution the particular learning modules render towards the entire learning arrangement.

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  • Capital ownership costs for milk production (economic depreciation and interest) are computed using the capital recovery approach. Capital recovery is an estimate of the cost of replacing the capital investment for cattle housing, milking facilities, feed storage structures, manure handling and storage structures, feed handling equipment, tractors, trucks, and purchased dairy herd replacements used up in the annual production process, plus interest that the remaining capital could have earned in an alternative use.

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  • Panelists from the Center for the Evaluation of Risks to Human Reproduction reviewed the literature for potential toxicities of HU. They concluded that HU does not cause a growth delay in children 5-15 years old . There were no data on the effects on subsequent generations following exposure of developing germ cells to HU in utero. Some evidence supported impaired spermatogenesis with use of HU. Although we identified six patients taking HU who developed leukemia, the evidence did not support causality.

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  • Strengthening business relationships: the ability to enhance business-to- business communications has a huge potential. In the past companies were using (EDI electronic data interchange to streamline business processes and enhance communications. Through EDI suppliers, manufacturers, distributors, and retailers were able to share information and enhance the flow of information and goods through the supply chain.

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