Preclinical research

Xem 1-20 trên 62 kết quả Preclinical research
  • While researching this book, I came across a letter in the journal Nature asking for caution in the current trend for the use of humorous nomenclature for newly discovered genes1, the author referring to the tumour suppressor gene Pokemon, which I have briefly described in Chapter 4.

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  • In the Western world, the arrival in the 20th century of the Welfare State meant that the basic needs of citizens in terms of health, hygiene and socio-economic considerations were met to a greater extent than ever before. It soon however became apparent that, as Maslow’s hierarchy of need predicts (Maslow, 1943), people continued to want more, they needed choices, and they sought opportunities to fulfil ambitions and goals.

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  • Research has revealed the crucial importance of involving the education sector in the process of agreeing to the potential benefits, as the two sectors have differ- ent criteria and values in relation to effectiveness and impact. It is vital that the education sector be convinced of the need to develop a policy on school health promotion. Such policy may be developed in isolation or, more likely, with support from the health sector or other partners.

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  • Funneling basic chemical, preclinical, and clinical data into a descriptive form useful to health care professionals, researchers, and educated, health-conscious consumers, Encyclopedia of Dietary Supplements presents peer-reviewed, objective entries that rigorously examine the most significant scientific research. It presents evidence-based information on the major vitamin and mineral micronutrients, single herbs and botanicals, phytochemicals, and other bioactive preparations.

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  • This book describes many aspects of tissue culture models in an extensive manner.

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  • The sex distribution in SEC is reasonably close to that in the 1998 census and 2000 DHS. The 1999 Socioeconomic Survey is somewhat out of line with the other sources. Likewise, the age distribution of older persons in the SEC is quite similar to that in the other sources. The marital status distribution in the SES for men is also fairly similar to that found in the other three sources but not for women. The SEC sample has relatively fewer women who are currently married and relatively more who are widowed than indicated by the census and the...

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  • To achieve success as a telemarketer, you’ll need to invest the necessary time and effort to learn and master a variety of different skills. Only then will you be able to truly tap your potential for generating the sales results you and your em- ployer want. This book divides up the skills you need, explains them in detail, and then offers strategies for developing and utilizing them.

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  • In the last part of the 20th century scientists discovered drugs that made the brain more resistant to ischemia, to such an extent that cerebral tissue treated with them was only little damaged, or was not damaged at all, by an ischemic insult that badly damaged control, untreated tissue. It was the beginning of a very exciting era in neuroscience research, a period when academic and industrial scientists all pursued the research of a “neuroprotectant” that could defend the ischemic brain from irreversible damage.

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  • This book describes applications in preclinical oncology research by bioluminescence imaging (BLI) with a variety of applications. Chapters describe current methodologies for rapid detection of contaminants using the Milliflex system, and the use of bioluminescence resonance energy transfer (BRET) technology for monitoring physical interactions between proteins in living cells.

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  • Benefit-cost ratios of intervention to control or prevent air pollution from household SFU will depend on what benefits and costs are included in the analysis and how non-market benefits and costs are valued. Health effects of air pollution are often a major concern and motivation for intervention. Which health effects to include and how they are valued are therefore an important consideration in an economic analysis. Large scale household stove programs have also been motivated by natural resource considerations, for instance in China in the 1980s.

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  • This book began as a collection of articles on neuropsychiatric disease, but with a clear focus on Schizophrenia, which is a poorly understood but very disabling group of brain disorders. We now recognize schizophrenia as a disorder of the brain, but despite advances in treatment options we are still a long way from having effective treatments, particularly for cognitive symptoms, and lack effective interventions and ways to prevent this disease.

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  • The retail trade has developed a system (without consulting the banking sector) which makes payments by bank card possible without any authorisation. This system is known as the electronic direct debit system (ELV). The customer’s signature on the receipt or an additional document authorises the dealer to collect the cost of the purchase by direct debit. However, the risks of a direct debit being returned on account of an objection or lack of cover, or possibly because the card has been blocked, are borne solely by the retail outlet.

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  • Tremoleda et al. EJNMMI Research 2011, 1:11 http://www.ejnmmires.com/content/1/1/11 REVIEW Open Access Imaging technologies for preclinical models of bone and joint disorders Jordi L Tremoleda1*, Magdy Khalil1, Luke L Gompels2, Marzena Wylezinska-Arridge1, Tonia Vincent2 and Willy Gsell1 Abstract Preclinical models for musculoskeletal disorders are critical for understanding the pathogenesis of bone and joint disorders in humans and the development of effective therapies.

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  • With regard to the ‘cause’ of this phenomenon, several explanations have been offered, including improvement in chemical restraints available for large animals, the elimination of gender-based admission discrimination and the generally caring portrayal of veterinarians in both the literature and on television (Lofstedt, 2003:534).

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  • Although the number of new infections among children has decreased sharply over the past several years (as noted previously in this report), greater efforts are needed to ensure that progress continues. Most cases of HIV infection among infants and children stem from insufficient information and counselling provision among women in regards to HIV/AIDS and sexual and reproductive rights and the lack of adequate antenatal care during pregnancy. Respondents consider all new cases to be inexcusable given the broad prevention mechanisms currently available.

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  • The first essay shows that this reference to painting allows the filmmaker to entail a process of reduction that points to a particular kind of sublime: a sublime of what is immobile, fallen, routed and diseased, a sublime made of what frightens. By filming ordinary and therefore invisible objects, by literally ‘emptying’ the image the camera performs a phenomenological reduction which suspends the intentionality in the constitution of the object. The anguish of banality is the sublime that crosses Antonioni’s cinema: the poor phenomenon becomes saturated.

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  • There is always a danger of taking any image or model too literally [5]. Using images in science or philosophy to illustrate states of affair is generally a two-edged sword because it is essential that the audience knows the limits of a picture and uses it with discrimination and intelligence. With that caution, I believe that art, having shed the requirement to visually represent reality accurately, is uniquely capable of instilling an intuition for the deeper aspects of reality that are hidden to the...

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  • This chapter provides an overview of the classical measures of risk- adjusted portfolio performance. We first describe the general logic that lies behind all of the measures, and then define the individual mea- sures. We then discuss the theoretical properties of the measures in more detail. Finally, we look at empirical estimation of the measures on actual managed portfolios, and review the empirical evidence based on the classical measures. The main idea in most of the classical measures of investment perfor- mance is quite simple.

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  • Buying advertising on the Mobile Web is similar to buying display advertising on the Internet. Graphical, interactive display ads are the predominant ad unit. In most cases, Mobile Web banner ad impressions can be purchased on a cost per thousand (CPM) or a cost per click (CPC) basis. Mobile offers targeting possibilities beyond that of traditional media. As this develops further, we would expect to see a range of targeting options made available covering context, demographic and behavioral attributes.

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  • As has been explained in Section 5.3.1 of “Doing Business in Mexico” on the marketing of consumer goods, rather basic distribution systems exist along with modern structures. The crisis of 1994/95 has even reinforced this gap: While many inefficient retailers were driven out of business and the trend to efficient distribution systems with fewer layers of intermediaries was reinforced, many Mexicans who had lost their job tried to make a living in retailing.

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