Primary responsibilities

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  • Management of Disseminated CUP Patients who present with liver, brain, and adrenal metastatic disease usually have a poor prognosis. Beside primary peritoneal carcinoma, carcinomatosis presenting as CUP in other settings is not uncommon. Gastric, appendicular, colon, pancreas, and cholangiocarcinoma are all possible primaries, and imaging, endoscopy, and pathologic data help in the evaluation. Traditionally, platinum-based combination chemotherapy regimens have been used to treat patients with CUP.

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  • Three distinct sequential cellular responses characterise the reaction of the adult spinal cord and brain to injury. An acute haemorrhagic phase immediately ensues after wounding, in which haematogenous cells flood the lesion site. This is followed by a subacute period during which macrophages clear necrotic debris, glial cell reactions are mobilised, the clot becomes organised, and scarring is initiated. Finally, the scar tissue contracts during a consolidation phase .

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  • Primary School Curriculum Science Social, Environmental and Scientific Education (SESE) provides opportunities for the child to explore, investigate and develop an understanding of the natural, human, social and cultural dimensions of local and wider environments; to learn and practise a wide range of skills; and to acquire open, critical and responsible attitudes. SESE enables the child to live as an informed and caring member of local, national, European and global communities.

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  • Finland France Georgia Germany Greece Hungary Iceland Ireland Israel Italy Kazakhstan Kyrgyzstan Latvia Lithuania Luxembourg Malta Monaco Montenegro Netherlands Norway Poland Portugal Republic of Moldova Romania Russian Federation San Marino Serbia Slovakia Slovenia Spain Sweden Switzerland Tajikistan The former Yugoslav Republic of Macedonia Turkey Turkmenistan Ukraine United Kingdom Uzbekistan

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  • In the general field of Environmental Psychology an increasing number of studies propose that subjects’ general well-being can be significantly increased as a result of contact with environments considered to have high aesthetic value. The present study has attempted to study the possible effects of the contemplation of everyday landscapes on citizens’ emotional well- being, identifying some of the main affective responses associated with aesthetic judgements of urban landscapes.

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  • Trí nhớ miễn dịch Hệ thống miễn dịch tạo ra các đáp ứng miễn dịch mạnh hơn và hiệu quả hơn khi được tiếp xúc lặp đi lặp lại với cùng một kháng nguyên. Đáp ứng với lần tiếp xúc đầu tiên được gọi là đáp ứng kỳ đầu (primary response) do các tế bào lympho “trinh nữ” (naive lymphocyte) lần đầu tiên tiếp xúc với kháng nguyên thực hiện.

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  • The goals of chemotherapy (and radiotherapy) are to eliminate tumor cell targets by promoting cell death. In recent years, a major focus has been placed on programmed cell death or apoptosis as the primary mechanism of cell killing. However, tumor cells may respond to various forms of treatment in diverse ways, only some of which culminate in cell death and loss of clonogenic survival. In addition to apoptosis, cell death may occur through mitotic catastrophe, autophagy (a subtype of apoptosis), or anoikis.

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  • Infertility is defined as the failure to conceive after one year of attempting pregnancy. Primary infertility denotes those patients who have never conceived. Secondary infertility applies to patients who have conceived previously. Approximately 15% of couples experience infertility, which may result from subfertility or sterility (the innate inability to conceive) in either partner or both. The female is responsible in 40%–50% of cases. The male is responsible in 30% and is contributory in another 20%–30% of couples.

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  • The creative process of advertising is guided by specific goals and objectives and requires the development of a creative strategy or plan of action for achieving the goal. Creative strategy development actually begins with a thorough assessment of the marketing and promotional situation and a determination of what needs to be communicated to the marketer’s target audience. Creative strategy should, however, also be based on a number of other factors that are stated in the creative or copy platform....

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  • Trachoma has an impact on the entire family, but the mother’s blinding trachoma appears to have the greatest impact on the daughter. The girl-child may have to take on household responsibilities to the detriment of her education when the mother is blind. A daughter’s dowry may be undervalued if it is perceived that her disabled family members will need care in the coming years. The balance of the household may be upset in numerous ways, potentially leading to eventual impoverishment. Changes in work routine reverberate within the family by causing further displacement.

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  • Thus, mutual funds, while going by a variety of names, are fairly comparable around the globe. 8 In this paper, we contrast mutual funds with other ways in which households might save and invest in financial assets, which we characterize broadly as “do-it-yourself (DIY)” and “opaque financial intermediaries.” Whereas a mutual fund is defined as a pooled diversified investment vehicle, “do-it- yourself” investments are direct investments by households in primary securities (bonds, stocks or cash).

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  • Reproduction of information in TI data books or data sheets is permissible only if reproduction is without alteration and is accompanied by all associated warranties, conditions, limitations and notices. Representation or reproduction of this information with alteration voids all warranties provided for an associated TI product or service, is an unfair and deceptive business practice, and TI is not responsible nor liable for any such use.

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  • A transponder is a receiver / transmitter device designed to transmit a response signal when legitimately interrogated. An automatic device that transmits a predetermined message in response to a predefined received signal.

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  • This reference to 'style and presentation* does no( adequately represent Philip's contribution, which led to much redrafting in the interests of consistency of style, terminology! layout, and level of detail. We also owe a special debt to Meg Davies for assuming primary responsibility for the conceptual index and compiling the index under very strict time constraints.

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  • The Immune Response While many constituents of infectious microorganisms and their products (e.g., exotoxins) are or can be rendered immunogenic, only some stimulate protective immune responses that can prevent infection and/or clinical illness or (as in the case of rotavirus) can attenuate illness, providing protection against severe disease but not against infection or mild illness. The immune system is complex, and many factors—including antigen composition and presentation as well as host characteristics—are critical for stimulation of the desired immune responses (Chap. 308).

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  • One unsolved issue concerns the role of the clonal B-cell receptor (BCR) in disease progression. Despite the fact that low expression of the BCR correlates with reduced induction of protein tyrosine kinase activity and defective intracellular calcium mobilization and tyrosine phosphorylation [66] this receptor conserves the capacity of antigen recognition and signaling, controlling thereby key behaviors of tumor cell, like proliferation and cell survival. Individual patients have different responses to IgM ligation which are related to VH gene status.

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  • The provinces have primary responsibility for property law in Canada. In all provinces except Québec, property law has developed through the English common-law process. In Québec, property law is governed by the Civil Code of Québec (which is derived from the Napoleonic Code.) There is no constitutional protection for property rights in Canada. Consequently, property can be expropriated by government and quasi-governmental authorities, but, appropriate compensation must be paid.

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  • Needles: Standard disposable 22-24 gauge 1-1½-inch needles are used for plain FNAC. The length and caliber of the needle should fit the size, depth, location and the consistency of the target. For small subcutaneous lesions, one-inch 23-gauge needle is ideal while for a deep-seated breast lesion, longer and larger needle is required. Finer needles are also recommended for children, and for vascular organs like thyroid. Syringes: Standard disposable plastic syringes of 10ml are used. Syringe should be of good quality and should produce good negative pressure.

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  • Even if the spouse is working full or part-time in the business, the primary owner usually retains primary responsibility for the functions of the business, or to a lesser extent, shares responsibility with the spouse. The only area where the spouse is more likely to have primary responsibility instead of sharing it with the primary owner is in accounting and finance (27 percent of spouses have sole control; 22 percent share), but it is still more likely the owner has primary responsibility (49 percent).

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  • The federal government enacted the Federal Alcohol Administration Act (FAAA) shortly after the repeal of Prohibition, and this legislation has served as the primary vehicle for regulating alcohol advertising in the United States. The Alcohol and Tobacco Tax and Trade Bureau (TTB) has primary responsibility for enforcing the FAAA. Consumer protection and advertising regulation are not, however, areas of expertise for the TTB, which is located within the Department of the Treasury, and the FAAA provides only limited authority and guidance.

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