Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Proinflammatory and proapoptotic markers in relation to mono and di-cations in plasma of autistic patients from Saudi Arabia
Anthrax lethal toxin triggers death in some cell types, such as macrophages,
and causes a variety of cellular dysfunctions in others. Collectively, these
effects dampen the innate and adaptive immune systems to allowBacillus
anthracis to survive and proliferate in the mammalian host.
Pancreaticb-cell dysfunction is a prerequisite for the development of type 2
diabetes. Alcoholism is a diabetes risk factor and ethanol increases oxida-tive stress in b-cells, whereas the mitochondrial chaperone prohibitin
(PHB) has antioxidant effects in several cell types.
Induction of p53 by the DNA damage and oncogene checkpoints.
In response to noxious stimuli, p53 and mdm2 are phosphorylated by the ataxia telangiectasia mutated (ATM) and related ATR serine/threonine kinases, as well as the immediated downstream checkpoint kinases, Chk1 and Chk2. This causes dissociation of p53 from mdm2, leading to increased p53 protein levels and transcription of genes leading to cell cycle arrest (p21Cip1/Waf1) or apoptosis (e.g., the proapoptotic Bcl-2 family members Noxa and Puma).
The release of apoptosis-inducing proteins from the mitochondria is regulated by pro- and antiapoptotic members of the Bcl-2 family. Antiapoptotic members (e.g., Bcl-2, Bcl-XL, and Mcl-1) associate with the mitochondrial outer membrane via their carboxy termini, exposing to the cytoplasm a hydrophobic binding pocket composed of Bcl-2 homology (BH) domains 1, 2, and 3 that is crucial for their activity.
Caspase-independent neuronal death has been shown to occur in neuroexci-totoxicity. Here, we tested the hypothesis that the gene encoding Bcl-2⁄E1B-19K-interacting protein 3 (BNIP3) mediates caspase-independent
neuronal death in excitotoxicity.
Although thiazolidinediones (TZDs) are potent promoters of adipogenesis
in the preadipocyte, they induce apoptosis in several other cell types,
such as cancer cells, endothelial cells and T-lymphocytes. In this study,
we investigated the proapoptotic effect of TZDs in mature 3T3-L1
adipocytes, which express high levels of the peroxisome proliferator-acti-vated receptor-c (PPARc) protein.
Thymoquinone, a naturally derived agent, has been shown to possess anti-oxidant, antiproliferative and proapoptotic activities. In the present study,
we explored thymoquinone effects on the proteasomal complex, the major
system involved in the removal of damaged, oxidized and misfolded pro-teins.
14-3-3 is a family of proteins comprising several isoforms that, in many cases,
promote cell survival by association with proapoptotic proteins. This study
was designed to obtain further understanding of the 14-3-3 role in apoptosis
regulation, by analyzing apoptosis-related protein–14-3-3 interactions.
Monoclonal nonspecific suppressor factorb (MNSFb) is a ubiquitously
expressed member of the ubiquitin-like family that has been implicated in
various biological functions. Previous studies have demonstrated that
MNSFbcovalently binds to the intracellular proapoptotic protein Bcl-G in
cells of the macrophage cell line Raw264.7, suggesting involvement of this
ubiquitin-like protein in apoptosis.
Nucling is an Apaf1-binding proapoptotic protein involved in apoptosome-mediated apoptosis. Luciferase assays have revealed that the activation of
nuclear factor-jB induced by tumor necrosis factor-a, interleukin-1band
lipopolysaccharide is downregulated by the overexpression of Nucling in
Viral subversion of apoptosis regulation plays an important role in the
outcome of host⁄virus interactions. Although human cytomegalovirus
(HCMV) encodes several immediate early (IE) antiapoptotic proteins (IE1,
IE2, vMIA and vICA), no proapoptotic HCMV protein has yet been iden-tified. Here we show that US28, a functional IE HCMV-encoded chemo-kine receptor, which may be involved in both viral dissemination and
immune evasion, constitutively induces apoptosis in several cell types.