Transcriptional control of the progesterone receptor gene by estrogen is a
complex mechanism. It involves estrogen receptora which uses several
enzymes that locally modify histone tails as cofactors. Using MCF-7 cells
as a model, we found that Jumonji AT-rich interactive domain 1A
(JARID1A; KDM5A⁄RBP2), an enzyme that removes the activating
H3K4 di- and trimethylation marks, was involved in the fine-tuning of pro-gesterone receptor gene expression.
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Expression of estrogen and progesterone receptors in vestibular schwannomas and their clinical significance
Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Progesterone receptor does not improve the performance and test effectiveness of the conventional 3-marker panel, consisting of estrogen receptor, vimentin and carcinoembryonic antigen in distinguishing between primary endocervical and endometrial adenocarcinomas in a tissue microarray extension study
Since all of these flavors are present in beer, it is important that beer judges completely coat the inside
of their mouths with beer when evaluating it and that the beer be swallowed. As is true for the scent
receptors in the nose, different people have different densities of taste buds and, thus, have different
sensitivities to various flavors. Also, taste buds can be damaged (e.g., being burnt by hot food or
through exposure to irritants like spicy foods, smoking, or other chemicals), so a judge’s sensitivity may
be diminished until tastebuds can regenerate (about 10 days).
Gprotein-coupled receptor 30 (GPR30) has previously been
described tobe important in steroid-mediatedgrowthand to
inhibit cell proliferation. Here we investigated whether the
effect of GPR30 on cell growth is dependent on steroid
hormone receptors. We stably introduced GPR30 in
immortalizednormalmammaryepithelial (HME) cellsusing
retroviruses for gene delivery. GPR30 inhibited the growth
and proliferation of the cells. They expressed glucocorticoid
receptor, but not estrogen or progesterone receptor....
• Menopausal hormone therapy: Some studies have
suggested that women who take estrogen by itself
(estrogen without progesterone) for 10 or more
years may have an increased risk of ovarian cancer.
Scientists have also studied whether taking certain
fertility drugs, using talcum powder, or being obese are
risk factors. It is not clear whether these are risk
factors, but if they are, they are not strong risk factors.
Having a risk factor does not mean that a woman
will get ovarian cancer. Most women who have risk
factors do not get ovarian cancer.
The Merriam-Webster Dictionary defines telemarketing
as the marketing of goods or services by telephone. It’s a word
that was added to the dictionary back in 1980, when it became
obvious that the telephone was changing the way companies
In general, people are busy. They don’t want to be both-
ered by others trying to sell them products or services that
aren’t needed. A successful telemarketer can quickly capture
the attention of the person he or she is calling and prove to that
person that what you’re offering could be beneficial.
In this review, will be summarize the principle of these new methodologies and the impact
of omics-techniques, mainly genomic-transcriptomics (analysis of single nucleotide
polymorphisms or gene-expression) and proteomic (identification and quantification of
proteins), in the knowledge of different aspects of allergy diseases (diagnosis, screening,
monitoring of treatment, protective or risk biomarkers and drug development) and the
advance to define the personalized and molecular medicine in this complex kind of diseases....
In 1989, Hodge et al. published two papers in the Journal of Urology (Hodge et al., 1989a
and 1989b). The first paper described directed transrectal prostate biopsies of palpable
abnormalities, 90% of which had corresponding hypoechoic lesions on ultrasound (Hodge
1989a). Additional biopsies were also taken of isoechoic areas of the peripheral and
central zones. These biopsies were not systematic and they were found to be positive in
66% of cases.
The second article was a landmark paper which marked the start of the modern era of
prostate needle biopsy (Hodge et al., 1989b).
Contraceptive methods can be divided into two subgroups as hormonal and non-hormonal.
Hormonal contraceptives include combined-oral contraceptives, progestin only pills,
hormonal implants, progestin releasing intrauterine systems, depomedroxyprogesterone
acetate injections, and vaginal rings. Non-hormonal contraceptive methods include male and
female condoms, copper intrauterine device, tubal ligation and vasectomy of the companion.
Combined oral contraceptives are a widely used and well accepted form of contraception.
If I may, I would like to finish with a request. This request is
made on behalf of the members of our Society who do not
speak English. I would like to ask the Society members who
speak English as their first language to reduce the complexity
of their conversation to a level that is easier to understand for
those who do not speak English. Also, I ask members who are
not native speakers of English to do their best to improve their
English skills. In fact, more than 80% of our members are non-
native speakers of English, yet it...
These criteria are
classified into its safety profile, performance within the GI tract and technological
aspects of its development. The criteria are further dependent on the specific purpose
of the strain and on the location for the expression of the specific property. With
regards to safety, the probiotic strain must be of human origin, isolated from the
gastrointestinal tract (GIT) of healthy individuals.
In general, pregnant women’s access to HIV testing is high due to the
implementation in 2001 of a national policy mandating that all pregnant
women be offered an HIV test at the first level of health care. However,
one result of Argentina’s federal system is that there are great disparities
around the country in terms of health care availability and quality,
including in regard to prevention of vertical transmission coverage
and services. In some cities fewer than 70 percent of pregnant women
take an HIV test prior to going into labour2
The program has reached providers in over 33 states through train-the-trainer sessions and conferences. Much of the information provided in this report was gained or substantiated through extensive interaction with providers around the United States and internationally. Ultimately through a large evaluation component, impact of the training on preparedness, creation of plans, and staff will be reported.
Given the unprecedented—by recent standards—financial crisis
that has devastated the world financial system and extended its
reach into a number of other sectors, political risk insurance has
become even more relevant. At the same time, questions remain as
to whether PRI really covers those risks that investors need covered
A single premium life insurance policy is one where you pay an amount
(a premium) to the insurer at the beginning of the policy. You may also be
able to pay additional premiums. This type of policy pays out a lump sum
on its maturity or if you (or another life assured) should die. You may also
withdraw sums or a loan may be made by the insurer or by arrangement
with it, while the policy is in force, or you may sell or assign the policy or
surrender it completely before it is due to mature.
This type of policy can never be a qualifying...
Health is a fundamental human right, especially for individuals held in the custody of the state.
Although women should be entitled to the same rights as men, prison systems were primarily
designed for men, and many prisons do not have adequate facilities to protect women’s rights or
to promote their health. Compounding the difficulty of addressing this problem is the lack of data
and research about women’s health status while in prison. Health systems must include
penitentiary health policies that integrate women’s health needs in all phases of planning and
In the present series of studies, we analyzed the lyrics in popular songs in an
attempt to identify the existence of embedded reproductive/evolutionary messages. Being
the first of their kind, these were largely descriptive studies.
The adaptive value of music eluded scientists for a long time. While Pinker (1997)
has been quick to dismiss music as “auditory cheesecake,” Darwin (1871) suggested that
music may have evolved as a form of courtship display by means of sexual selection.
Following Darwin’s lead, there is now growing interest in the origins of music (e.g.
During the second half of the 1990s, mortgage underwriting increasingly incorporated
credit scores and other automated evaluations of credit histories. As of 1999,
approximately 60 to 70 percent of all mortgages were underwritten using an automated
evaluation of credit, and the share was rising2
The automated quantification of the information in credit reports has not simply been
used to decide whether or not to extend credit, but has also been used to set prices and
terms for mortgages and other consumer credit.
Because of improvements in air quality, such
deadly air pollution episodes are rare in U.S. cities.
Modern research methods have shown, however,
that deaths and serious illnesses from common
air pollutants still occur at levels well below
regulatory standards, and at current levels in
New York and most large cities. Local actions to
further reduce air pollution will mean changes in
policies and behaviors, and will require significant
investments in new vehicles and other equipment.