We have shown recently that in human T lymphocytes,
leptin stimulates activity and expression of the endocan-nabinoid-degrading enzyme fatty acid amide hydrolase
(FAAH), through STAT3 (signal transducer and activator
of transcription 3) and its CRE (cAMP response element)-like transcriptional target in the FAAH promoter [Maccar-rone, M., Di Rienzo, M., Finazzi-Agro`,A., &Rossi,A.
(2003) J. Biol. Chem. 278, 13318–13324]. We have also
shown that progesterone, alone or additively with leptin,
up-regulates theFAAHgene in human T-cells, through the
Ikaros transcription factor [Maccarrone, M.