Prostate cancer markers

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  • “Advances in Prostate Cancer” is an addition to the InTech collection of three previous books about prostate cancer and aims at providing a comprehensive overview of specific aspects of the latest research and current knowledge relating to this tumor entity to scientists and clinicians. For this purpose a series of research articles, clinical investigations and reviews that deal with a wide range of relevant aspects pertinent to the epidemiology, diagnosis, patient care, treatment and basic biology of prostate cancer were included.

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Prostate cancer genomics: can we distinguish between indolent and fatal disease using genetic markers?

    pdf7p panasonic02 15-12-2011 18 3   Download

  • Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Can urinary exosomes act as treatment response markers in prostate cancer?

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: "High-dose intensity-modulated radiotherapy for prostate cancer using daily fiducial marker-based position verification: acute and late toxicity in 331 patients...

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: " Potentials of on-line repositioning based on implanted fiducial markers and electronic portal imaging in prostate cancer radiotherapy...

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Identification of candidate predictive and surrogate molecular markers for dasatinib in prostate cancer: rationale for patient selection and efficacy monitoring...

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  • Results from the univariate analysis of prostate cancer mortality and incidence do not take into account the effect of different covariables, which might influence the SMR and SIR. Various covariables where considered to model longitudinal effects: age, calendar year, year of immigration, length of stay in Germany; cohort was considered for the analysis of mortality. Multivariate Poisson regression did not show any significant effect of the considered covariables on mortality (data not shown).

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  • One authorized urologist (M.M.) performed all the operations. We used a standard TURP setup with an irrigation pressure of 80 cmH2O and an irrigation rate of 250 ml/min using D-sorbitol solution. After a rough resection of almost all the transition and central zone, we tried to resect and fulgurate the peripheral zone as completely as possible, especially where cancer was detected by biopsy. The resection was continued until adipose tissue, venous sinus or the external sphincter was identified.

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  • PSA (prostate-specific antigen), the most useful serum marker for prostate cancer, is encoded by thehKLK3gene and is present in the serumas amixture of several molecular species. This work was performed to identify the hKLK3 transcripts in order to determine how many proteins resembling PSA are synthesized from thehKLK3gene and secreted in blood. Combined Northern blotting, molecular cloninganddatabase searching showed that thehKLK3gene produces at least 15 transcripts ranging in size from 0.7 to 6.1 kb. Polysomal distribution analysis revealed that the transcripts shorter than 3.

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  • Human glandular kallikrein 2 (hK2) is a trypsin-like serine protease expressed predominantly in the prostate epithelium. Recently, hK2 has proven to be a useful marker that can be used in combination with prostate specific antigen for screening and diagnosis of prostate cancer. The cleavage by hK2 of certain substrates in the proteolytic cascade suggest that the kallikrein may be involved in prostate cancer development; however, there has been very little other progress toward its biochemical characterization or elucidation of its true physiological role.

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  • EDRN is at the forefront of technology-driven research on the use of biomarkers for the early detection of cancer. By identifying and validat- ing biomarkers, such as novel proteins or changes in gene expression, it is possible to measure an individual’s disease risk, progression of disease, or response to therapy. Ultimately, EDRN research will aid in prevention and in early therapeutic intervention, based on early detection of disease.

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  • Role of Immunohistochemical Analysis Immunohistochemical stains are peroxidase-labeled antibodies against specific tumor antigens that are used to define tumor lineage. The number of available immunohistochemical stains is ever-increasing. However, in CUP cases, more is not necessarily better, and immunohistochemical stains should be used in conjunction with the patient's clinical presentation and imaging studies to select the best therapy. Communication between the clinician and pathologist is essential. No stain is 100% specific, and over-interpretation should be avoided.

    pdf5p thanhongan 07-12-2010 29 3   Download

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