Xem 1-4 trên 4 kết quả Proteases f
  • Papain-like cysteine proteases of pathogenic protozoa play important roles in parasite growth, differentiation and host cell invasion. The main cysteine proteases of Trypanosoma cruzi(cruzipain) and of Trypanosoma brucei (brucipain) are validated targets for the development of new chemothera-pies.

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  • "Molecular imaging" has been previously defined as "the in vivo characterization and measurement of biologic processes at the cellular and molecular level." This broad definition emerged during the last few years as a consequence of the convergence of molecular and cell biology with imaging science, including medical physics and technology. One of the major goals of molecular imaging has become the development of noninvasive strategies of "molecular profiling" in living subjects, i.e.

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  • The serpin plasminogen activator inhibitor-1 (PAI-1) is a fast and specific inhibitor of the plasminogen activating serine proteases tissue-type and urokinase-type plasminogen activator and, as such, an important regulator in turnover of extracellularmatrixand infibrinolysis. PAI-1 spontaneously loses its antiproteolyticactivityby inserting its reactive centre loop (RCL) as strand 4 in b-sheet A, thereby converting to the so-called latent state.

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  • Using thein situ liver model system, we have recently shown that, after cholera toxin binding to hepatic cells, cholera toxin accumulates in a low-density endosomal compartment, and then undergoes endosomal proteoly-sis by the aspartic acid protease cathepsin-D [Merlen C, Fayol-Messaoudi D, Fabrega S, El Hage T, Servin A, Authier F (2005)FEBS J272, 4385– 4397]. Here, we have used a subcellular fractionation approach to address the in vivo compartmentalization and cytotoxic action of cholera toxin in rat liver parenchyma....

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