Radiation, Health and Society The Nuclear Phenomenon Radioactive Decay Radiation all Around Us Radiation and Living Tissue Radiation Protection High Doses Nuclear Power Chernobyl - A Case Study Conclusion...
Vitamin E Deficiency: Treatment
Symptomatic vitamin E deficiency should be treated with 800–1200 mg of αtocopherol per day. Patients with abetalipoproteinemia may need as much as 5000–7000 mg/d. Children with symptomatic vitamin E deficiency should be treated with 400 mg/d orally of water-miscible esters; alternatively, 2 mg/kg per d may be administered intramuscularly. Vitamin E in high doses may protect against oxygen-induced retrolental fibroplasia and bronchopulmonary dysplasia, as well as intraventricular hemorrhage of prematurity.
Radiology is an essential component of dental diagnosis. Available
data clearly show that ionizing radiation, if delivered in sufficient
doses, may produce biological damage. However, it is not clear
that radiation in doses required for dental radiography presents
any risk. Neither is it clear that these small doses are free of risk.
Table 81-2 Commonly Used Cancer Chemotherapy Agents
Exam ples of Usual Doses
Direct DNA-Interacting Agents
Liver metabolism required
phosphoramide 100 mg/m2 PO qd Common alkylatora Mesna protects Cardiac dose) against Cystitis mustard + acrolein
(high "high-dose" bladder damage
6 mg/m2 IV day
Topical use in cutaneous lymphoma
Vesicant 1 and day 8 Nausea
1–3 mg/m2 qd PO
Adipophilin is a 50 kDa protein that belongs to the PAT family (perilipin,
adipophilin, TIP47, S3-12 and OXPAT), which comprises proteins involved
in the coating of lipid droplets. Little is known about the functional role of
adipophilin in muscle. Using the C2C12 cell line as a model, we demon-strate that palmitic acid-treated cells highly express the adipophilin protein
in a dose-dependent way.
Regimen efficiency and simplification. Another key
advantage of Options B and B+ is greater efficiency, very
much in accord with Treatment 2.0 principles. First, the same
simplified, fixed-dose combination ARV regimen can be used
throughout the PMTCT intervention. Further, it is possible, and
highly desirable, to provide the same regimen both for PMTCT
and as the first-line national ART regimen for non-pregnant
To be effective, concentrations of an antibacterial agent must exceed the pathogen's MIC. Serum antibiotic concentrations usually exceed the MIC for susceptible bacteria, but since most infections are extravascular, the antibiotic must also distribute to the site of the infection. Concentrations of most antibacterial agents in interstitial fluid are similar to free-drug concentrations in serum.