Xem 1-20 trên 161 kết quả Protein aggregation
  • The molecular biology underlying protein aggregation and neuronal death in Alzheimer’s disease is not yet completely understood, but small soluble nonamyloid aggregates of the amyloidb-protein (Ab) have been shown to play a fundamental neurotoxic role.

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  • Proteins might aggregate into ordered or amorphous structures, utilizing relatively short sequence stretches, usually organized in b-sheet-like assem-blies. Here, we attempt to list all available software, developed during the last decade or so, for the prediction of such aggregation-prone stretches from protein primary structure, without distinguishing whether these algo

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  • Protein aggregation can proceed via disordered or ordered mechanisms, with the latter being associated with amyloid fibril formation, which has been linked to a number of debilitating conditions including Alzheimer’s, Parkinson’s and Creutzfeldt-Jakob diseases. Small heat-shock proteins (sHsps), such as aB-crystallin, act as chaperones to prevent protein aggre-gation and are thought to play a key role in the prevention of protein-mis-folding diseases.

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  • The unfolding process of the Blue Copper Protein (BCP) rusticyanin (Rc) has been studied using a wide variety of biochemical techniques. Fluorescence and CD spectroscop-ies reveal that the copper ion plays an essential role in sta-bilizing the protein and that the oxidized form is more efficient than the reducedspecies in this respect. Theaddition of guanidinium chloride to Rc samples produces aggrega-tion of the protein. Gel filtration chromatography and glutaraldehyde cross-linking experiments confirm the for-mation of such aggregates. ...

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  • Inclusion bodies are insoluble protein aggregates usually found in recombi-nant bacteria when they are forced to produce heterologous protein species. These particles are formed by polypeptides that cross-interact through sterospecific contacts and that are steadily deposited in either the cell’s cytoplasm or the periplasm.

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  • Autophagy is an evolutionarily conserved lysosomal pathway used to degrade and recycle long-lived proteins and cytoplasmic organelles. This homeostatic ability makes autophagy an important pro-survival mechanism in response to several stresses, such as nutrient starvation, hypoxia, dam-aged mitochondria, protein aggregation and pathogens.

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  • It is assumed that protein fibrils manifested in amyloidosis result from an aggregation reaction involving small misfolded protein sequences being in an ‘oligomeric’ or ‘prefibrillar’ state. This review covers recent optical spectroscopic studies of amyloid protein misfolding, oligomerization and amyloid fibril growth.

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  • Aggregation of the normal cellular prion protein, PrP, is important in the pathogenesis of prion disease. PrP binds glycosaminoglycan (GAG) and divalent cations, such as Cu 2+ and Zn 2+ . Here, we report our findings that GAG and Cu 2+ promote the aggregation of recombinant human PrP (rPrP).

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  • In the biomineralization processes, proteins are thought to control the polymorphism and morphology of the crystals by forming complexes of structural and mineral-associated proteins. To identify such proteins, we have searched for proteins that may form high-molecular-weight (HMW) aggregates in the matrix of fish otoliths that have aragonite and vaterite as their crystal polymorphs.

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  • It is well established that in addition to its functional role in cell motility, cell division and intracellular transport, cyto-skeletal protein tubulin also possesses significant chaperone-like activity. In vitro studies from our laboratory showed that dimeric tubulin can prevent stress induced aggregation of substrate proteins, can resist thermal deactivation of enzymes and can also refold enzymes from their fully dena-tured state [Manna, T., Sarkar, T., Poddar, A., Roy-chowdhury, M., Das, K.P. & Bhattacharyya, B....

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  • Accumulations of aggregated proteins are a key feature of the pathology of all of the major neurodegenerative diseases. Amyotrophic lateral sclerosis (ALS) was brought into this fold quite recently with the discovery of TDP-43 (TAR DNA binding protein, 43 kDa) inclusions in nearly all ALS cases.

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  • As limited structural information is available on prion protein (PrP) mis-folding and aggregation, a causative link between the specific (supra)mole-cular structure of PrP and transmissible spongiform encephalopathies remains to be elucidated.

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  • The study of protein aggregation saw a renaissance in the last decade, when it was discovered that aggregation is the cause of several human dis-eases, making this field of research one of the most exciting frontiers in science today. Building on knowledge about protein folding energy land-scapes, determined using an array of biophysical methods, theory and simulation, new light is now being shed on some of the key questions in protein-misfolding diseases.

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  • Our results generally showed that in the investigated microbial community autotrophic component was dominant over the heterotrophic component during the winter season, while dominance of heterotrophic component in the microbial community was observed during the warmer seasons. Further, within the prokaryotic community heterotrophic prokaryotes were mostly dominant throughout the studied area.

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  • The pressure for B2B marketers is on. Modern B2B buyers have an increasing tendency and capacity to research purchasing decisions online long before they engage with Sales. They are empowered with information, and are reluctant from a persistently struggling economy. Winning over modern B2B buyers requires organizations to revolutionize their marketing approach, and the barriers to success are vast. Facing great scrutiny, we must act on the buyer’s terms, tie all activities into revenue, and continually optimize performance.

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  • The DOE’s Carbon Sequestration Program also supports global initiatives, such as the Carbon Sequestration Leadership Forum (CSLF), an international climate change initiative that focuses on the development of technologies to cost-effectively capture and sequester CO2, and the International Energy Agency (IEA). The Carbon Sequestration Program is also providing technical and financial support to international projects through the Core R&D MVA Program. Projects include the Weyburn Project (see Section 3.

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  • This study of a large, nationally representative sample of Australian women who had recently given birth provides the first examination of consultancy patterns across conventional maternity care providers and CAM practitioners during pregnancy. The study presents four key findings. First, the study reveals a substantial level of CAM practitioner use with nearly half of the pregnant women consulting a CAM practitioner concurrent to conventional maternity care.

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  • Target marketing is based on fundamental marketing principles that are employed by just about all firms across all types of products and toward all types of audience segments. As the nation undergoes dramatic demographic shifts, moving today’s ethnic minorities to the majority in many geographic areas, target marketing to ethnic groups will increase.

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  • But what does this trend in competition do for the cities? The answer is certainly not definitive, but in its emerging outlines, it is disturbing yet also offers hope. To the extent that this tendency makes cheap labor locations around the world more accessible, it fur- ther amplifies the competitive disadvantage of urban locations in the United States. The impact of increases in trade with low-wage countries on U.S. employment, especially on low-skilled workers, has been hotly debated (Freeman, 1995; Wood, 1995).

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  • Someone with a physical illness or disability often needs hands-on or stand-by assistance with activities of daily living (see page 19). People with cognitive impairments usually need supervision, protection or verbal reminders to do everyday activities. The way long-term care services are provided is changing. Skilled care and personal care are still the terms used most often to describe long-term care and the type or level of care you may need.

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