The Protein Data Bank contains the description of approximately 27 000
protein–ligand binding sites. Most of the ligands at these sites are biologi-cally active small molecules, affecting the biological function of the protein.
The classification of their binding sites may lead to relevant results in drug
discovery and design.
PA-TM-RING proteins have an N-terminal protease-associated domain, a
structure found in numerous proteases and implicated in protein binding,
and C-terminal RING finger and PEST domains. Homologous proteins
include GRAIL (gene related to anergy in leukocytes), which controls
T-cell anergy, and AtRMR1 (receptor homology region-transmembrane
domain-RING-H2 motif protein), a plant protein storage vacuole sorting
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Substitution of adeno-associated virus Rep protein binding and nicking sites with human Chromosome 19 sequences
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Conserved retinoblastoma protein-binding motif in human cytomegalovirus UL97 kinase minimally impacts viral replication but affects susceptibility to maribavir
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Hepatitis C virus NS5A protein binds the SH3 domain of the Fyn tyrosine kinase with high affinity: mutagenic analysis of residues within the SH3 domain that
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: "The HTLV-1 Tax protein binding domain of cyclin-dependent kinase 4 (CDK4) includes the regulatory PSTAIRE helix
Although highly conserved throughout evolution, the exact biological
function of the prion protein is still unclear. In an effort to identify the
potential biological functions of the prion protein we conducted a small-molecule screening assay using the Syrian hamster prion protein [shPrP(90–
To identify and gain a better understanding of the cadherin-like receptor-binding site onBacillus thuringiensisCry toxins, it is advantageous to use
Cry1Aa toxin, because its 3D structure is known. Therefore, Cry1Aa toxin
was used to examine the locations of cadherin-like protein-binding sites.
Initial experiments examining the binding compatibility for Cry1Aa toxin
of partial fragments of recombinant proteins of a 175 kDa cadherin-like
protein from Bombyx mori(BtR175) and another putative receptor for
Cry1Aa toxin, aminopeptidase N1, fromBo. ...
The current volume entitled Protein Purification is designed to facilitate rapid access to valuable information about various methodologies. It aims as well to provide an overview of state-of-art techniques for the purification, analysis and quantification of proteins in complex samples using different enrichment strategies.Protein purification is a series of processes intended to isolate a single type of protein from a complex mixture. Protein purification is vital for the characterization of the function, structure and interactions of the protein of interest....
TBP (TATA - Binding Protein) là protein liên kết đặc hiệu DNA với đoạn trình tự của hộp TATA. TBP có chức năng biến tính DNA và bẻ cong phân tử DNA một góc 90°. Điều này cần thiết để khởi động cho cơ chế phiên mã. TBP bám vào rãnh nhỏ của phân tử DNA bằng một cấu trúc nếp gấp beta. Vai trò của TBP Trong quá trình phiên mã ở những tế bào eukaryote, TBP là thành phần bắt buộc của nhân tố phiên mã TFIID để khởi động chính xác quá trình này đối với...
Proteins are the driving force for all cellular processes. They regulate several cellular
events through binding to different partners in the cell. They are capable of binding to
other proteins, peptides, DNA, and also RNA. These interactions are essential in the
regulation of cell fates and could be important in drugs development. For example
RNA interacting proteins regulate gene expression through the binding to different
mRNAs. These mRNAs could be involved in important cellular processes such as cell
survival or apoptosis.
In this series of four minireviews the field of scaffold proteins and proteins
of similar molecular⁄cellular functions is overviewed. By binding and bring-ing into proximity two or more signaling proteins, these proteins direct the
flow of information in the cell by activating, coordinating and regulating
signaling events in regulatory networks.
Proteins p53 and p73 act as transcription factors in cell cycle control, regu-lation of cell development and⁄or in apoptotic pathways. Both proteins
bind to response elements (p53 DNA-binding sites), typically consisting of
two copies of a motif RRRCWWGYYY.
The type II fatty acid synthase pathway ofPlasmodium falciparumis a
validated unique target for developing novel antimalarials because of its
intrinsic differences from the type I pathway operating in humans.
b-Ketoacyl-acyl carrier protein reductase is the only enzyme of this pathway
that has no isoforms and thus selective inhibitors can be developed for this
player of the pathway.
This minireview series examines the structural principles underlying the
biological function of RNA-binding proteins. The structural work of the
last decade has elucidated the structures of essentially all the major RNA-binding protein families; it has also demonstrated how RNA recognition
takes place. The ribosome structures have further integrated this knowledge
into principles for the assembly of complex ribonucleoproteins. Structural
and biochemical work has revealed unexpectedly that several RNA-binding
proteins bind to other proteins in addition to RNA or instead of RNA....
PUF proteins regulate both stability and translation through sequence-spe-cific binding to the 3¢ UTR of target mRNA transcripts. Binding is medi-ated by a conserved PUF domain, which contains eight repeats of
approximately 36 amino acids each. Found in all eukaryotes, they have
been related to several developmental processes.
Pentatricopeptide repeat (PPR) proteins constitute a large family in land
plants and are required for various post-transcriptional steps associated with
RNA in plant organelles. The mossPhyscomitrella patensPPR protein,
PpPPR_38, is a nuclear-encoded chloroplast protein and was previously
shown to be involved in the maturation step of chloroplastclpPpre-mRNA.
An homology model of human P-glycoprotein, based on the X-ray struc-ture of the recently resolved mouse P-glycoprotein, is presented. The
model corresponds to the inward-facing conformation competent for drug
binding. From the model, the residues involved in the protein-binding cav-ity are identified and compared with those in the outward-facing confor-mation of human P-glycoprotein developed previously based on the