Protein contaminant detection

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  • Before the days of mass literacy, medicine was more art than science, and people recognized a pharmacy by the four traditional colored bottles that represent earth, fire, air, and water. Medicine has come a long way since the days of the apothecary with its impressive collection of powders and bottles; drugs today are highly regulated and must comply with standards set by the U.S., Europe, Japan, and other countries. A drug must be shown to be efficacious and meet rigorous standards of purity, composition, and potency before being approved for use in the patient populatio...

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  • This book describes applications in preclinical oncology research by bioluminescence imaging (BLI) with a variety of applications. Chapters describe current methodologies for rapid detection of contaminants using the Milliflex system, and the use of bioluminescence resonance energy transfer (BRET) technology for monitoring physical interactions between proteins in living cells.

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  • Spain was (and still is) the largest producer of mercury in the world. Stories of Spanish galleons carrying tonnes of gold and silver looted from Central and South America back to Spain are well documented. Less well known is the fact that many tonnes of mercury were shipped from Spain to the “New World.” The Spanish conquistadors used that mercury to process precious metals. Parts of Mexico are still heavily contaminated from the thousands of tonnes of mercury that were brought from Spain during the four-hundred-year period of Spanish rule.

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  • Introduction: Small amount of drugs and poisons incorporated into human bodies are hidden among large amounts of biological components, such as proteins, lipids, nucleic acids and membranes. It is not easy to detect only a target compound from such complicated matrices. Before instrumental analysis, extraction procedure is usually essential and very important.

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