Biomedical research has entered a new era of characterizing a disease or a protein on a global scale. In the post-genomic era, Proteomics now plays an increasingly important role in dissecting molecular functions of proteins and discovering biomarkers in human diseases. Mass spectrometry, two-dimensional gel electrophoresis, and high-density antibody and protein arrays are some of the most commonly used methods in the Proteomics field.
biomarker là tập thể của một số gene hay protein tiêu biểu cho một trạng thái thay đổi sinh học. Như đã nêu trên, nền tảng của nghiên cứu Biomarker dựa trên các protein, vì thế vai trò của nghiên cứu
proteomics là thiết yếu. Tuy nhiên số lượng lớn lao (dự đoán khoảng từ 300.000 đến 500.000 protein), và đặc biệt là bản chất phức tạp của protein là một trở ngại lớn cho các nghiên cứu biomarker. ...
Nutrigenomics, proteomics and metabolomics are three
new disciplines that will contribute to the rapid development
of functional foods. Bioinformatics is a new tool that uses
computer database technology to integrate data from
multiple, and sometimes disparate, disciplines. Already
these disciplines and tools have improved our understanding
of food science and human nutrition. Discoveries in genetics
make it possible to understand the effects of nutrients in
processes at the molecular level in the body and also the
variable effects of dietary components on each individual.
Proteomics là khoa học mũi nhọn của y sinh học thế kỷ 21, trong đó trọng tâm chính là nghiên cứu ung thư. Nghiên cứu những vấn đề này sẽ góp phần lớn lao trong việc tìm hiểu bệnh sinh của bệnh tất ở mức độ phân tử, trong việc tìm ra các dấu ấn sinh học (biomarker) để chẩn đoán bệnh, chế tạo thuốc có tác dụng tốt nhất theo cơ chế phân tử.
More recently, Cox and Fisher (2009) analyzed the titles of contemporary romance
novels to determine if their popularity might be related to evolutionary themes that would
be expected to have widespread appeal when it comes to some of the unique and recurrent
reproductive issues that women confront. The five most common words featured in
romance novel titles were love, bride, baby, man, and marriage, in that order. Common
themes extracted from these titles included commitment, reproduction, masculine/high
ranking suitors, and resources.
The book Renal Failure – The Facts consists of some facts about diagnosis,
etiopathogenis and treatment of acute and chronic renal failure. Acute, as well as
chronic renal failure is great medical problems and their treatment is a burden for the
budget of each government.
Acute kidney injury (AKI), previously termed acute renal failure, is a frequent clinical
condition in critically ill patients especially, in intensive care units (ICU). Its incidence
varies from 1-7 % of all hospitalized patients to 30-50 % of patients in ICU....
Eight different isomeric forms of vitamin E (4 tocopherols and 4 tocotrienols) have been
found in nature. Tocotrienols (α, β, γ and δ) are identical in structure to tocopherols except
for the degree of saturation in their side chain. However, α-tocopherol is considered to be
the most active form of vitamin E in humans. It has been found that the concentrations of
vitamin E isomers in human feces are higher than in plasma – possibly due to its limited
absorption from the diet, suggesting that it could play a protective role against RONS
produced in the GI tract (Halliwell...
Although we are primarily interested in the housing consumption of the elderly, we did not limit
our analysis to the householders aged 62 and older. For comparison purposes, we looked at all
householders. We did this by segregating the householder population into seven age cohorts.
The number of age cohorts is large enough to let us capture changes in housing consumption
over individuals’ lifecycle, without being overly burdensome on the analysis. The cohort widths
have been defined such that they can mirror reasonable life bands.
Today, cancer research is focused on determining how genome and proteome level
information may be useful as tools in prevention, diagnosis, and prognosis. The
development of “omics” technologies, such as proteomics and transcriptomics has
opened new research areas for scientists working on cancer research.
In 2003, a man from one of the charity organizations referred Martha to Likii HIV’s Home based care group
because the support she was getting was not sustainable. Lucy Njoki, a caregiver from Likii and also a woman
living with HIV welcomed her and shared her story with other caregivers in the group. Caregivers contributed
some money to rent a house for her and ensure that she received food daily. Caregivers also referred her to the
comprehensive care unit at the district hospital where she resumed ART treatment. In 2004/2005, her health...
Lean thinking is not a manufacturing tactic or a cost-reduction program, but a management strategy
that is applicable to all organizations because it has to do with improving processes. All organizations
— including health care organizations — are composed of a series of processes, or sets of actions
intended to create value for those who use or depend on them (customers/patients).
The importance of fisheries in a country cannot only be measured by the contribution to
the GDP, but one must also take into consideration that fisheries resources and products
are fundamental components of human feeding and employment.
Another aspect that makes fisheries resources important is the self renewable character.
Unlike mineral resources, if the fishery resources or any other biological resources are
well managed, their duration is pratically unlimited.
Persons who are ill will be asked to defer travel so as not to spread influenza to other
areas that are pandemic free. Supply lines may also be affected by self-imposed travel
restrictions, with truckers/transporters unwilling to travel through or to infected areas.
Difficulties at border crossings may substantially affect supply lines. Consideration
should be given to purchase of products made in Canada/locally to avoid potential
supply problems due to border crossing restrictions implemented at the time of the
Many risks that we face on a daily basis may be unavoidable, so there is an expectation
by individuals that the level of risk is being managed and reduced to safe levels
through evidence-based risk assessments and public health interventions. There has
been a growing recognition that risks need to be viewed in their public health context
to ensure that the most important risks are prioritized and addressed. Under a
broader public health imperative, risk assessments are used as an important process to
quantify the probability of harmful effects to individuals, sub-populations (eg.
The objective of this current chapter is to review the techniques whose potential to noninvasively
determine Breslow index has been studied. Basic and technical principles of each
technique will be mentioned as well as their accuracy in the determination of a factor whose
importance in the clinical management of melanoma is so important as previously
demonstrated. Currently Breslow index is measured by the anatomo-pathologist after
incisional or excisional biopsy of the suspected lesion. So why non invasive determination of
Breslow index would be of utmost clinical value?...
The UK is an open economy and an active and successful international trader and
investor. But the UK’s reliance on debt-financed consumer and government spending,
and on the financial sector, has driven growing imbalances in the UK economy.
According to the OECD, by 2007 the UK had the largest structural budget deficit in the
G7 group of countries. The current account deficit was around 2¾% of GDP in 2007, a
figure that was offset by a 2¼% surplus on trade in financial services.
Coinciding with the option explosion, a large academic literature has emerged (See Murphy,
1999, for a summary) that examines the way in which executive compensation, and stock options
in particular, has affected the agency relationship. The evidence suggests that the low pay-to-
performance relationship estimated by Jensen and Murphy (1991) has been dramatically
strengthened by the stock option explosion since executives now generally have very large holdings
of company stock and stock options in their portfolios (Hall and Liebman, 1998).
An unusually large number of people sickened by a disease in a certain place and
time is known as a ‘disease cluster’. Clusters of cancer, birth defects, and other
chronic illnesses have sometimes been linked to chemicals or other toxic pollutants
in local communities, although these links can be controversial. There is a need for
better documentation and investigation of disease clusters to identify and address
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Evaluating the potential of a novel oral lesion exudate collection method coupled with mass spectrometry-based proteomics for oral cancer biomarker discovery...