Thus, in living cells, the rates of anterograde and retrograde transport between the two
organelles appear to have a substantial effect on the morphology of the Golgi. The effect of
the balance between anterograde and retrograde transport on the morphology of the ER
remains to be explored. Recently, increasing evidence has suggested that alteration in Golgi
morphology during mitosis is not a passive process but rather an active one, which is highly
coordinated with entry into mitosis and its progression.
The prognosis for individuals with liver cancer is frequently poor. Cancers include those which have metastasized to the liver from elsewhere, reflecting advanced stage disease where cure is rarely possible. Similarly, primary liver cancer frequently complicates chronic liver disease, which further limits therapeutic options. Despite these dismal facts, there are signs that change is imminent. Not only have imaging modalities and surgical techniques improved, but preventive strategies and medical therapies show promise.
The essential role of epidemiology is to improve the health of populations. Advances
in epidemiology research are expected to play a central role in medicine and public
health in the 21st century by providing information for disease prediction and
This book represents an overview on the diverse threads of epidemiological research
in that captures the new and exciting themes that have been emerging over recent
The book Recent Advances in the Biology, Therapy and Management of Melanoma brings up-to-date information regarding a number of aspects which culminate in illuminating potential targets in the fight against melanoma. This book is intended to be a reference book for both the scientific and clinical communities and brings complicated subject matter together in an easy, readable way. Undoubtedly fundamental scientific understanding has to then be translated to the clinic in order for us to make significant strides in eradicating melanoma.
On behalf of the Research Society on Alcoholism, I am pleased to introduce
this thirteenth volume of Recent Developments in Alcoholism about alcohol and
violence. Current concepts are presented in well-organized sections that focus
on epidemiology, neurobiology, psychology, and family issues. It is becoming
increasingly clear that age, gender, socioeconomic circumstances, and
genetics affect aggressive behavior and vulnerability to alcoholism. This volume
contains up-to-date discussions of these issues.
Advances in our understanding of the molecular principles underlining both health and disease
has revealed the existence of many regulatory polypeptides of significant medical potential. The
fact that such polypeptides are produced naturally within the body only in minute quantities
initially precluded their large-scale medical application. The development in the 1970s of the
twin techniques of genetic engineering and hybridoma technology marked the birth of the
modern biotech era.
Recent advances in clinical proteomics have propelled us into an exciting period of discovery of
new cancer biomarkers, although the available proteomic technologies have their limitations. The
principles of proteomic technology require stringent guidelines for the collection of clinical material,
the application of analytical techniques, and for our interpretation of the data.
In this review, we present an overview of the serum tumor markers in current use.
Given the unusual circumstances of Cambodia and their likely impacts on the older population,
considerable effort was made to develop a survey questionnaire that not only would cover the standard
issues about elderly economic, social and physical well-being that are the focus of recent surveys of older
age populations in the region but also issues specific for the situation in Cambodia.
Injuries cause more than half of all deaths among children in the United States. The
spectrum of causes varies with age, but blunt forces cause the overwhelming majority
of injuries. Children are not just small adults. They differ in many ways from adults.
Many of the differences in behavior, risk exposure, anatomy, and physiology have a
direct bearing on trauma care. In recent years, this reality has been widely accepted in
Gastroesophageal reflux disease (GERD) is one of the most common gastrointestinal disorders in the
Western world. In recent years, there have been many developments in the field of GERD. At least, all these
developments have helped to find new diagnostic procedures and different treatment concepts. As well
known, GERD affects patients quality of life and leads to a significant economic burden on society. Therefore,
all further investigations should primary aim in an improvement of patients daily life.
The Tenth Edition of the Handbook of Clinical Drug Data continues a long
tradition of providing clinically relevant, well-referenced drug information compiled
by expert clinicians and presented in a compact format. The formats of all
sections should be familiar to users of the ninth edition. As with recent editions,
information in the Handbook is divided into three part
The intent of Vascular Dementia: Cerebrovascular Mechanisms and Clinical Management
is to address the many recent advances in cardiovascular and cerebrovascular medicine
and the impact of these on the lives of older adults by examining the state-of-the-art
research on vascular dementia (VaD). A distinguishing feature of this work is its interdisciplinary
nature. We have assembled work from contributors in multiple related fields, including
both human and animal studies, in order to advance our collective understanding of
This compact and concise monograph lays a foundation for the understanding of normal cardiovascular function. Students welcome the book as a practical partner or alternative to a more mechanistically oriented approach or an encyclopedic physiology text. Especially clear explanations, ample illustrations, clinical cases and problems, and chapter-opening learning objectives provide guidance for self-directed learning and help fill the gap in many of today's abbreviated physiology blocks. A focus on well-established cardiovascular principles reflects recent, widely accepted research....
This book has been written to fill a need for a basic but
comprehensive text dealing with all aspects of paediatric
ENT. It is aimed at trainees in our specialties who are
developing an interest in the paediatric aspects of their
work, at established ENT surgeons and audiologists who
have decided to specialise in this most enjoyable subspecialty,
or who wish to know more about paediatric ENT,
and as a work of reference for those who encounter particular
problems in their paediatric patients.
World Health Statistics 2006 presents the most recent statistics since 1997 of 50 health indicators for
WHO’s 192 Member States. This second edition of World Health Statistics includes an expanded set of
statistics, with a particular focus on equity between and within countries. It also introduces a section with
10 highlights in global health statistics for the past year.
World Health Statistics 2006 has been collated from publications and databases of WHO’s technical programmes
and regional offices.
Extreme Prematurity: Practices, Bioethics, and the Law examines the
controversial issues surrounding the clinical management of this
group of neonates through the intervention of modern neonatal
intensive care. The forgoing of life-sustaining treatment is of particular
importance. The subject matter is very relevant because of
the alarming increase in multiple and preterm births, caused by the
increase in women undergoing assisted reproductive procedures,
and the large increase in premature labor. No recent book covers
the subject in such comparable breadth....
Since the primitive beginnings of operative surgery, surgeons have had a need
to work with assistance, even if it was, in those early times, merely for the
purposes of physical restraint. As surgical and anaesthetic practice became more
sophisticated, so were the tasks becoming more complex and the demand on the
surgical team ever increasing.
STROKE IS THE THIRD MOST COMMON CAUSE of death
and disability in the US. It is a complex disease, with many
causes, many presentations, and many levels of severity. Despite
recent medical advances, stroke remains a diffi cult disease
to diagnose and treat. In recognition of the importance of this
common disorder, the American Board of Psychiatry and Neurology
(ABPN) instituted a new subspecialty examination in
In recent years, the amount of knowledge surrounding the processes of wound healing
has significantly increased, resulting in a vast array of therapeutic options. The
assortment of preparations currently available may become somewhat perplexing
to physicians and medical personnel.
We have become aware of the difficulty involved in selecting the most appropriate
therapy for a specific type of wound. Our main purpose in writing this book,
therefore, is to present a step-by-step algorithmic approach to the treatment of
Hemodynamic monitoring is one of the major diagnostic tools available in the
acute care setting to diagnose cardiovascular insufficiency and monitor changes
over time in response to interventions. However, in recent years, the rationale and
efficacy of hemodynamic monitoring to affect outcome has come into question.
We now have increasing evidence that outcome from critical illness can be improved
by focused resuscitation based on existing hemodynamic monitoring,
whereas non-specific aggressive resuscitation impairs survival.