Many mycobacterial species, including M. tuberculosis, grow extremely slowly in the
laboratory and require 3–8 weeks of incubation on solid medium or at least 2 weeks in a
radiometric liquid culture system (BACTEC). This slow growth often leads to delay in TB
diagnosis. Nucleic acid amplification (NAA) methods allow for detection of mycobacterial
DNA or RNA directly from the specimens before the culture results are available. The Food
and Drug Administration (FDA) has approved two NAA tests for direct detection of M.
tuberculosis from clinical specimens.
The second part of the book is dedicated to the pathogenesis of myocarditis. The
chapters in this part also discuss some clinical findings, but mostly focus on the
underlying mechanism of the disease, using in-depth data from mouse models. Some
of the chapters focus on host immune response. For example, one chapter reviews the
role of pattern-recognition receptors in myocarditis, and another chapter examines the
role of lymphocyte effectors in myocarditis pathogenesis.
Field data are being integrated into well-developed and tested models to better understand and
characterize aerosol pollution in Mexico City. The spatial, temporal, size, and chemical
characteristics of specific emissions sources are needed to allow their contributions to PM
concentrations to be distinguished from each other and to provide accurate inputs to air quality
2004Tuberculosis is a major health problem throughout the world causing large number of deaths,more than that from any other single infectious disease. The review attempts to summarize theinformation available on host immune response to Mycobacterium tuberculosis. Since the mainroute of entry of the causative agent is the respiratory route, alveolar macrophages are theimportant cell types, which combat the pathogen. Various aspects of macrophage-mycobacteriuminteractions and the role of macrophage in host response such as binding of M.