Recurrent aphthous

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  • During the annual meeting of the Medical Society of Athens on November 15, 1930 Benediktos Adamantiades (1875-1962) (Fig. 1), Greek ophthalmologist from Prussa, Asia minor (nowadays Bursa, Turkey) 1-3 , presented in a lecture with the title ”A case of relapsing iritis with hypopyon ”, a 20-year-old male patient with the three cardinal signs of the disease. The disease had begun at the age of 18 with edema and ulcerations at the left leg diagnosed as thrombophlebitis.

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  • Áp-tơ niêm mạc miệng là bệnh thường gặp, nguyên nhân chưa rõ, bệnh thường tự giới hạn. Dịch tễ học Tần số: đây là bệnh thường gặp, hầu hết người lớn đã từng bị áp-tơ trong cuộc đời. Giới: gặp ở nữ nhiều hơn nam. Tuổi: RAS minor: khoảng 1% trẻ em Mỹ bị RAS, thường khởi phát trước 5 tuổi. Tỷ lệ bị bệnh tăng lên theo tuổi. RAS major thường khởi phát sau tuổi dạy thì. Herpetiform RAS thường khởi phát ở tuổi 20 (khoảng 60-85%).

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  • Ulcers Ulceration is the most common oral mucosal lesion. Although there are many causes, the host and pattern of lesions, including the presence of systemic features, narrow the differential diagnosis (Table 32-1). Most acute ulcers are painful and self-limited. Recurrent aphthous ulcers and herpes simplex infection constitute the majority. Persistent and deep aphthous ulcers can be idiopathic or seen with HIV/AIDS. Aphthous lesions are often the presenting symptom in Behçet's syndrome (Chap. 320).

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  • Neutrophil Abnormalities A defect in the neutrophil life cycle can lead to dysfunction and compromised host defenses. Inflammation is often depressed, and the clinical result is often recurrent with severe bacterial and fungal infections. Aphthous ulcers of mucous membranes (gray ulcers without pus) and gingivitis and periodontal disease suggest a phagocytic cell disorder. Patients with congenital phagocyte defects can have infections within the first few days of life. Skin, ear, upper and lower respiratory tract, and bone infections are common. Sepsis and meningitis are rare.

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