Akcros stabilizer/activators have been formulated to provide
controlled, uniform gas evolution for the production of PVC foams
utilizing azodicarbonamide as the blowing agent. The ABC series of
blowing agent catalysts are primary materials and act as both heat
stabilizers and gas generation activators. No secondary stabilizer is
normally required. Thus, with the availability of such blowing agent
catalysts, the use range of azodicarbonamide is extended to a
Over the past two decades the NCRP has carried out several studies
and issued two reports on problems associated with a possible nuclear
attack on this country. In each of these reports, any questions centering
primarily about a nuclear reactor accident were avoided. The
Council noted, however, the increasing interest in the potential of
protective actions for alleviating some of the effects of the release of
radioactive materials that might ensue in the event of a reactor
Modified release coatings
John E.Hogan SUMMARY Relevant aspects of the composition and performance of modified release coatings are considered in this chapter. Initially, the basic characteristics of multiparticulate systems are described and comparisons are made with the performance of whole tablets intended for modified release. The properties and effects of the polymers and plasticizers which are used in modified release coatings are illustrated with examples from the literature. This further develops the basic treatment of these materials provided in Chapter 2.
We recommend that you install the most recent software release to stay up-to-date with the latest functional
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The latest version of this document is at:
IBM Systems Director Service and Support Manager is a no-charge “call-home”plug-in to automatically report hardware problems and collect system service information for monitored systems (Electronic Service Agent tool).
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Discovery of a new chemical entity that exerts pharmacological effects for
curing or treating diseases or relieving symptoms is only the first step in
the drug developmental process. In the developmental cycle of a new
drug, the delivery of a desired amount of a therapeutic agent to the target
at a specific time or duration is as important as its discovery. In order
to realize the optimal therapeutic outcomes, a delivery system should
be designed to achieve the optimal drug concentration at a predetermined
rate and at the desired location....
We investigated the survival signals of epidermal growth factor (EGF) in
human gastric adenocarcinoma cell line TMK-1. Treatment of TMK-1 cells
with adriamycin (ADR) caused apoptosis and apoptosis-related reactions
such as the release of cytochromecfrom mitochondria and the activation
of caspase 9.
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Costs and effects of paliperidone extended release compared with alternative oral antipsychotic agents in patients with schizophrenia in Greece: A cost effectiveness study...
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: The problem of secondary contamination following chemical agent release...
It apparently does this by inhibiting the release of neurotransmitters, chemicals that carry nerve impulses from one neuron to the next. (10) Like many other agents that affect neuron firing, adenosine must first bind to specific receptors on neuronal membranes.
The theory of neurohumoral transmission received direct experimental validation nearly a century
ago (see von Euler , 1981 ), and extensive investigation during the ensuing years led to its general
acceptance. Nerves transmit information across most synapses and neuroeffector junctions by
means of specific chemical agents known as neurohumoral transmitters or, more simply,
This chapter describes the physiological role and pathophysical consequences of histamine release
and provides a summary of the therapeutic use of histamine H1-receptor antagonists. H2-receptor
antagonists are discussed in detail in Chapter 37: Agents Used for Control of Gastric Acidity and
Treatment of Peptic Ulcers and Gastroesophageal Reflux Disease in the context of prevention and
treatment of peptic ulcers, their principal therapeutic application.
This book is intended to provide an overview of the pharmacology of neurotransmitter
release. Neurotransmitter release initiates synaptic transmission, the major
mechanism by which neurons communicate with each other and with effector cells.
I hereby (a) release the State of Oregon and its commissions, agencies, officers, employees, contractors, and agents, and agree to defend and indemnify the foregoing from and against any claims, demands, or costs (including attorney and expert witness fees at trial and on appeal) arising from or in any way related to claims made by applicant or any parent or subsidiary of applicant and which are related in any way to the Oregon Department of Energy’s issuance or failure to issue any pre-certification or final certification to applicant for a Business Energy Tax Credit, or the inability to...
The undersigned Tax Credit Recipient hereby releases the State of Oregon and its commissions, agencies, officers, employees, contractors, and agents, and agrees to defend and indemnify the foregoing from and against any claims, demands, or costs (including attorney and expert witness fees at trial and on appeal) arising from or in any way related to claims made by Tax Credit Recipient or any parent or subsidiary of Tax Credit Recipient and which are related in any way to the Oregon Department of Energy’s issuance or failure to issue any pre-certification or final certification to applican...
Oxidative stress, followed by the apoptotic death of pancreaticbcells, is
considered to be one of causative agents in the evolution of the type 2 dia-betic state; therefore, the protection ofbcells can comprise an efficacious
strategy for preventing type 2 diabetes. In the present study, RIN-m5F cells
(i.e. the rat insulinoma bcell line) were stimulated with streptozotocin,
resulting in a time- and concentration-dependent release of lactate
Triatoma infestans(Hemiptera: Reduviidae) is a hematophagous insect that
transmits the protozoan parasite Trypanosoma cruzi, the etiological agent
of Chagas’ disease. Its saliva contains trialysin, a protein that forms pores
in membranes. Peptides based on the N-terminus of trialysin lyse cells and
fold into a-helical amphipathic segments resembling antimicrobial peptides.
Using a specific antiserum against trialysin, we show here that trialysin is
synthesized as a precursor that is less active than the protein released after
saliva secretion. ...
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a recently
mobilizing messenger, and probably the most potent. We
briefly review its unique properties as a Ca
mobilizing agent. We present
arguments for its action in targeting acidic calcium stores rather than the
endoplasmic reticulum. Finally, we discuss possible biosynthetic pathways
for NAADP in cells and candidates for its target Ca
which has eluded identification so far.
Overall, the evidence appraised suggested that monotherapy with metformin produced
significantly greater improvements in glycaemic control (i.e. HbA1c and FPG/fasting blood
glucose (FBG)) when it was compared with placebo, diet and sulfonylureas. Head-to-head
comparisons with other antidiabetic agents (i.e. alpha-glucosidase inhibitors, thiazolidinediones,
meglitinides and insulin) and extended-release formulations of metformin, failed to show more
benefit for glycaemic control than standard monotherapy with metformin.