Summarizing a decade of scientific advance and therapeutic innovation, Renal Tumor offers all physicians treating kidney cancer, as well as researchers, updated information concerning the epidemiology, biology, and treatment of renal cell carcinoma. Contributors to this book are from all over the world and are experts in their individual fields.
(BQ) Part 1 book "Rare tumors and Tumor-Like conditions in urological pathology" presentation of content: Renal tumors and Tumor-Like conditions, tumors and Tumor-Like conditions of urinary bladder, renal pelvis, ureter and urethra.
In 1999 it was estimated that renal cell carcinoma (RCC) would account for
29,990 new cancer cases diagnosed in the United States (61% in men and 39%
in women), and lead to 11,600 deaths. RCC accounts for 2–3% of all malignancies
in adults and causes 2.3% of all cancer deaths in the United States
annually (1). Approx 4% of all RCC cases are bilateral at some point in the life
of the patient. Data from over 10,000 cases of renal cancer entered in the
Connecticut Tumor Registry suggests an increase in the incidence of renal
cancer from 1935–1989; in women the incidence increased from 0.
(BQ) Part 2 book "Pediatric malignancies pathology and imaging" presentation of content: Pediatric cancer in the head and neck, malignancies of the pediatric lower respiratory tract, gastrointestinal, pancreatic and hepatic malignancies in children, malignant renal tumors, germ cell and gonadal tumours,...
The multicentric nature of the disease and high rate of recurrence has led to the hypothesis of a field defect in the urothelium that results in a predisposition to cancer. Molecular genetic analyses suggest that the superficial and invasive lesions develop along distinct molecular pathways in which primary tumorigenic aberrations precede secondary changes associated with progression to a more advanced stage.
The treatment of a tumor that has invaded muscle can be separated into control of the primary tumor and, depending on the pathologic findings at surgery, systemic chemotherapy. Radical cystectomy is the standard, although in selected cases a bladder-sparing approach is used; this approach includes complete endoscopic resection; partial cystectomy; or a combination of resection, systemic chemotherapy, and external beam radiation therapy. In some countries, external beam radiation therapy is considered standard.
The primary goal of treatment for metastatic disease is to achieve complete remission with chemotherapy alone or with a combined-modality approach of chemotherapy followed by surgical resection of residual disease, as is done routinely for the treatment of germ cell tumors. One can define a goal in terms of cure or palliation on the basis of the probability of achieving a complete response to chemotherapy using prognostic factors, such as Karnofsky Performance Status (KPS) (...
The major pathogenic mechanism of poststreptococcal glomerulonephritis (PSGN) is an in
situ immune complex formation due to deposition of streptococcal nephritogenic antigens,
such as nephritis-associated plasmin receptor (NAPlr) and Streptococcal pyrogenic exotoxin
B (SPE B). Both are capable of activating the alternate pathway of the complement cascade
and enhance the expression of adhesion molecules. SPE B also stimulates the production of
NAPlr was isolated from group A streptococcus and was shown to bind plasmin(ogen).
The presenting signs and symptoms include hematuria, abdominal pain, and a flank or abdominal mass. This classic triad occurs in 10–20% of patients. Other symptoms are fever, weight loss, anemia, and a varicocele (Table 90-4). The tumor can also be found incidentally on a radiograph. Widespread use of radiologic cross-sectional imaging procedures (CT, ultrasound, MRI) contributes to earlier detection, including incidental renal masses detected during evaluation for other medical conditions.
Renal Cell Carcinoma: Treatment
Localized Tumors The standard management for stage I or II tumors and selected cases of stage III disease is radical nephrectomy. This procedure involves en bloc removal of Gerota's fascia and its contents, including the kidney, the ipsilateral adrenal gland, and adjacent hilar lymph nodes. The role of a regional lymphadenectomy is controversial. Extension into the renal vein or inferior vena cava (stage III disease) does not preclude resection even if cardiopulmonary bypass is required.
The interaction of the antibacterial phosphonodipeptide
/peptide cotransporters was
studied in Caco-2 cells, expressing the low-affinity intestinal
type peptide transporter 1 (PEPT1), and SKPT cells,
expressing the high-affinity renal type peptide transporter 2
(PEPT2). Alafosfalin strongly inhibited the uptake of
C]glycylsarcosine withKi values of 0.19 ± 0.01 mMand
0.07 ± 0.01 mMfor PEPT1 and PEPT2, respectively.
Despite the aberrant expression of cholinesterases in tumours, the question of
their possible contribution to tumorigenesis remains unsolved. The identifica-tion in kidney of a cholinergic system has paved the way to functional studies,
but details on renal cholinesterases are still lacking. To fill the gap and to
determine whether cholinesterases are abnormally expressed in renal
tumours, paired pieces of normal kidney and renal cell carcinomas (RCCs)
were compared for cholinesterase activity and mRNA levels....
Angiogenic switch in renal cell carcinoma (RCC) is attributed to the
inactivation of the von Hippel–Lindau tumor suppressor, stabilization of
hypoxia inducible factor-1 transcription factor and increased vascular
endothelial growth factor.
In the past 15 years, molecular biologists and geneticists have uncovered
some of the most basic mechanisms by means of which normal stem cells
in a certain organ or tissue develop into cancerous tumors. This biological
knowledge serves as a basis for various models of carcinogenesis.
It is clear from the studies cited below, that good bedside manner and professionalism are
extremely important to patients. Plunkett and Midland (2000) found that “well-educated”
Caucasians (from Chicago, Michigan, US) placed an emphasis on communication skills
when selecting an obstetrician. In contrast, patients who were to undergo surgery decided
the surgical reputation of the OB/GYN was more important than bedside manner.
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:
Massive hematuria due to a congenital renal arteriovenous malformation mimicking a renal pelvis tumor: a case report
In the early 1990's when systematic biopsy of prostate using transrectal ultrasonography
(TRUS) had just begun, there was enthusiasm for identifying abnormalities and obtaining
appropriate samples. Since the occurrences of early small prostate cancer are increasing and
identifying tumors using TRUS are somewhat subjective, the efficiency of the method in
detecting and staging prostate cancer has decreased. (Ohori, et al. 2003) Instead, many
physicians discuss about where and how many biopsy cores should be taken in order to
improve the detection-rate of cancer.