The faithful and complete replication of
chromosomes is essential to maintain
genetic stability and prevent the accumulation
of cancer-promoting mutations.
Replication forks are vulnerable to stalling
or collapse as they encounter obstacles on
the DNA template, which can be unrepaired
DNA damage, DNA-bound proteins or
secondary structures. Similarly, chemical
agents like hydroxyurea and aphidicolin
inhibit replication elongation, leading to
fork stalling or collapse.
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Inhibition of HIV-1 replication by P-TEFb inhibitors DRB, seliciclib and flavopiridol correlates with release of free P-TEFb from the large, inactive form of the complex...
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: LMP-420, a small-molecule inhibitor of TNF-alpha, reduces replication of HIV-1 and Mycobacterium tuberculosis in human cells...
HIV-1 reverse transcriptase (RT) has two associated activities, DNA poly-merase and RNase H, both essential for viral replication and validated drug
targets. Although all RT inhibitors approved for therapy target DNA poly-merase activity, the search for new RT inhibitors that target the RNase H
function and are possibly active on RTs resistant to the known non-nucleoside inhibitors (NNRTI) is a viable approach for anti-HIV drug
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Human immunodeficiency virus integrase inhibitors efficiently suppress feline immunodeficiency virus replication in vitro and provide a rationale to redesign antiretroviral treatment for feline AIDS...
The two-component NS2B–NS3 protease of West Nile virus is essential for
its replication and presents an attractive target for drug development. Here,
we describe protocols for the high-yield expression of stable isotope-labelled samples in vivo and in vitro.
Sterol regulatory element-binding protein (SREBP)-1a is a unique mem-brane-bound transcription factor highly expressed in actively growing cells
and involved in the biosynthesis of cholesterol, fatty acids, and phospholip-ids. Because mammalian cells need to synthesize membrane lipids for cell
replication, the functional relevance of SREBP-1a in cell proliferation has
been considered a biological adaptation.
The dengue virus two-component protease NS2B/NS3 mediates processing of the viral polyprotein precursor and is therefore an important determinant of virus replication. The enzyme is now intensively studied with a view to the structure-based development of antiviral inhibitors. Although 3-dimensional structures have now been elucidated for a number of flaviviral proteases, enzyme-substrate interactions are characterized only to a limited extend.